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Herodotus's enigmatic Scythian theleia nousos/morbus femininus and its Hippocratic interpretation interested many early modern authors. Its seeming dimension of transgender identification invited various medico-psychological and psychiatric reflections, culminating in nosologist de Sauvages' tentative 1731 term, melancholia Scytharum. Foretinib This article identifies pertinent discussions and what turn out to have been entangled, tentative psychologizations in late-seventeenth through mid-nineteenth-century mental medicine of 'effeminacy of manners' (mollities animi such as observed in London's Beaux and mollies) and male homosexuality (amour antiphysique/grec); of the mental masculinity of some women (viragines, Amazones); of ubiquitous attributions of impotence to sorcery (anaphrodisia magica); and lastly, of transfeminine persons encountered throughout the New World and increasingly beyond.While cure rates in pediatric oncology have improved over the past 30 years, childhood cancer remains the second leading cause of death in children aged 1 to 14. Developing therapies often require using cancerous tissues, which may come from deceased donors. Tumor banks collect, store, and distribute these donated samples. While tumor banking is more common, factors that contribute to parents' decision and the impact of it on the family are not well understood. The purpose of this hermeneutic study was to understand the meaning and impact of tumor banking for parents of children who have died from cancer. Findings suggest that parents donating their child's tumors unexpectedly found a sense of meaning in their loss. They also found a legacy of their child's life; the living cells in some ways assisted the parents with grief. Aspects of this sensitive conversation and decision are discussed from the perspective of the parents' experiences.

To investigate the effect of angulation of permanent mandibular second molars (MM2) on eruption problems and investigate a new method of measuring MM2 angulation for the diagnosis and evaluation of delayed tooth eruption (DTE) for easy use in dental practice.

Retrospective study.

Department of Orthodontics, Necmettin Erbakan University.

A total of 98 patients aged 9-18 years.

Patients with 64 permanent MM2s with delayed eruption problems were included in the study group. The control group consisted of patients with 83 normally erupted teeth. In addition, a sub-group, consisting of 23 patients showing unilaterally delayed eruption of the same teeth, was set as a split-mouth group. All patients with unilateral delayed eruption of second molar teeth were selected from the study group to form the sub-group. Angulations of permanent MM2s were measured on panoramic radiographs with two measurement methods (1) a new method; and (2) a previously accepted method. The comparison of the study and control groups was performed by Mann-Whitney U-test and the split-mouth group was analysed with the paired t-test. The

value was set at 0.05 for statistical significance.

Measurements of the tooth angulation values of the study group were significantly higher than in the control group for both measurement methods (

< 0.001). In addition, in the split-mouth group, angulation values of delayed eruption side were significantly higher than the erupted side (

< 0.001).

Increased angulations of permanent MM2s could be associated with delayed eruption problems of these teeth. This new method could be useful in clinical dentistry to determine the eruption evaluation of lower second molars.

Increased angulations of permanent MM2s could be associated with delayed eruption problems of these teeth. This new method could be useful in clinical dentistry to determine the eruption evaluation of lower second molars.Transgender and gender diverse (TGD) children face increased behavioral health risks including suicidal behaviors and substance abuse. Parental affirmation is associated with behavioral health outcomes similar to non-TGD peers. This integrative review synthesizes and appraises evidence regarding experiences of parenting a TGD child in the United States or Canada from 2008 to 2018. Most parents across these 15 studies described affirming their child's gender at time of interview. Parents reported initial interpersonal processes (emotions, concerns, beliefs), sought education (frequently online), and described interactions with family members and professionals that were not always affirming. Parents accessed support groups but described their own well-being as a low priority relative to the child's needs. Parents' own needs for well-being may affect the process of parenting a TGD child and should be explored. Future research should address the experiences of non-parent family members and participants from more diverse backgrounds. Nursing education must consistently address gender affirming care.Loneliness has been associated with multiple negative outcomes. But what contributes to loneliness in the first place? Drawing from the literature on the importance of self-regulatory ability for successful social functioning, the present research explored the role of low self-control as a factor leading to loneliness. A set of four studies (and three additional studies in Supplementary Online Materials) using cross-sectional, experimental, daily diary, and experience sampling methods showed that lower self-control is associated with higher loneliness at both trait and state levels. Why does low self-control contribute to loneliness? Self-control failures that have negative implications for others lead to higher risks for being ostracized by others, which predicts increased feelings of loneliness over time. These results suggest that low self-control, which is often associated with negative intrapersonal outcomes, can have important interpersonal consequences by evoking ostracism, and consequently, loneliness.Previous research finds an association between spirituality and subjective well-being. However, the widespread use of poorly defined concepts of spirituality, tautological spirituality scales, and heavy reliance on cross-sectional samples cast doubts on prior findings. Here, we leverage ten waves of panel data from a nationally diverse longitudinal study to systematically test whether having spiritual beliefs leads to growth in personal well-being and life satisfaction (N = 3257, New Zealand, 2010-2020). Contrary to previous research, we find that belief in a spirit or life force predicts lower personal well-being and life satisfaction. However, in support of previous speculation, belief (relative to disbelief) in a spirit or life force predicts increasing personal well-being and life satisfaction over time. These findings are robust even while accounting for known demographic influences; they even hold among those who believe in a God but disbelieve in a spirit or life force. The recent growth in spiritual beliefs and decline in traditional religion across many industrial societies motivates further causal investigations of the mechanisms by which spiritual beliefs lead to growth in subjective well-being.

To date, little is known about the characteristics of patients who are admitted to a palliative care bed for end-of-life care. Previous data suggest that there are disparities in access to palliative care services based on age, sex, diagnosis, and socioeconomic status, but it is unclear whether these differences impact access to a palliative care bed.

To better identify patient factors associated with the likelihood/rate of admission to a palliative care bed.

A retrospective chart review of all initiated palliative care bed applications through an electronic referral program was conducted over a 24-month period.

Patients who apply and are admitted to a palliative care bed in a Canadian metropolitan city.

A total of 2743 patients made a total of 5202 bed applications to 9 hospice/palliative care units in 2015-2016. Referred and admitted cancer patients were younger, male, and more functional than compared to non-cancer patients (all

 < 0.001). Referred and admitted patients without cancer were mare "sicker" with very low performance status and poorer prognoses. Further studies investigating disease-specific clinical variables and support requirements may provide more insights into these observed disparities.The algorithm for the Dexcom G6 CGM System was enhanced to retain accuracy while reducing the frequency and duration of sensor error. The new algorithm was evaluated by post-processing raw signals collected from G6 pivotal trials (NCT02880267) and by assessing the difference in data availability after a limited, real-world launch. Accuracy was comparable with the new algorithm-the overall %20/20 was 91.7% before and 91.8% after the algorithm modification; MARD was unchanged. The mean data gap due to sensor error nearly halved and total time spent in sensor error decreased by 59%. A limited field launch showed similar results, with a 43% decrease in total time spent in sensor error. Increased data availability may improve patient experience and CGM data integration into insulin delivery systems.Late diagnosis of critical congenital heart disease (CCHD) is associated with higher levels of morbidity and mortality in neonates. Nearly all states have passed laws mandating universal pulse oximetry screening (POxS) of newborns to improve early detection rates of CCHD. We performed a retrospective chart review of all transthoracic echocardiograms (TTEs) interpreted by our institution on patients between 0 and 30 days of life in the years 2010 (prior to POxS) and 2015 (after POxS). Between 2010 and 2015, the number of neonatal TTEs interpreted by our institution decreased by 18.2%. In 2015, there were 46 neonates diagnosed with CCHD with a 78% prenatal detection rate. There was only one case of a true-positive POxS. Our study demonstrated that the initiation of POxS coincided with a significant decrease in neonatal TTEs, suggesting universal POxS may impart reassurance to primary providers leading to a decrease in TTE utilization.Posttraumatic stress disorder commonly occurs among U.S. military veterans. Therapeutic horseback riding (THR) has emerged as an adjunct therapy. We explored 20 veterans' perceived benefits, drawbacks and views of a 6-week THR program. Participants had confirmed diagnoses of posttraumatic stress disorder, traumatic brain injury, or both. Veterans rode the same horse weekly, the same day, at the same time. Data were collected as part of a randomized clinical trial testing the effects of THR on Post-Traumatic Stress Disorder. Veterans responded to an open-ended questionnaire. Content analysis was used for data analysis. Benefits were "Connection to the Horse," "Relaxing," "180 Degree Change," and "Meeting New People." Drawbacks were "None," "Struggle to Get There," "Pain," "Too Short," and "It is Structured." Overall perceptions were "I Absolutely Loved It," "Feel Again," "The Horse," "The People," and "No Worries." Participants viewed THR as positive. Findings may elucidate why THR may be clinically beneficial.

The goal in the treatment of stages II and III Kienböck disease is to restore lunate vascularity and halt the progression of avascular necrosis.

We report the outcomes for patients with stages II and III Kienböck disease treated with fourth extensor compartment artery vascularized bone grafting and temporary radiocarpal spanning internal fixation. Nine patients with a mean age of 28.8 years were included. Mean clinical and radiographic follow-up were 4.9 and 1.9 years, respectively.

Six patients had no change in Lichtman stage, 2 patients regressed 1 stage, and 1 patient progressed 1 stage. Mean postoperative quick disabilities of the arm, shoulder, and hand (QuickDASH) was 17.4. Mean postoperative visual analogue pain scale (VAS) was 1.8. Patients under age 25 trended toward improved clinical outcomes compared with patients over age 25. Two patients, aged 33 and 65, underwent proximal row carpectomy at a mean 30.5 months postoperatively.

In conclusion, the use of local vascularized bone graft with temporary internal radiocarpal spanning fixation provides a treatment option with outcomes comparable to existing literature with benefits inherent to internal immobilization.

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