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one tissue for regenerative dentistry.Inspired by the biological process of phosphorylation for which different sites of the same protein may have different activities and functions, we utilized phosphatase-based enzyme-instructed self-assembly (EISA) to construct self-assembled nanomedicine from the precursors with different phosphorylated sites. We found that, although the obtained self-assembling molecules after EISA were identical, the changes of EISA catalytic sites could determine the outcome of molecular self-assembly. The precursor with the phosphorylated site in the middle preorganized before EISA, while the ones with other phosphorylated sites could not preorganize before EISA. After EISA, the preorganized precursor then resulted in more stable and ordered assemblies than those of the others, which showed increased cellular uptake and up to 1.7-fold higher efficacy in an antitumor therapeutic compared to those assembled from unorganized precursors.Despite their promising potential, the real performance of lithium-sulfur batteries is still heavily impeded by the notorious shuttle behavior and sluggish conversion of polysulfides. Complex structures with multiple components have been widely employed to address these issues by virtue of their strong polarity and abundant surface catalytic sites. Nevertheless, the tedious constructing procedures and high cost of these materials make the exploration of alternative high-performance sulfur hosts increasingly important. Herein, we report an intrinsic defect-rich hierarchically porous carbon architecture with strong affinity and high conversion activity toward polysulfides even at high sulfur loading. Such an architecture can be prepared using a widely available nitrogen-containing precursor through a simple yet effective in situ templating strategy and subsequent nitrogen removal procedure. The hierarchical structure secures a high sulfur loading, while the intrinsic defects strongly anchor the active species and boost their chemical conversion because of the strong polarity and accelerated electron transfer at the defective sites. As a result, the lithium-sulfur batteries with this carbon material as the sulfur host deliver a high specific capacity of 1182 mAh g-1 at 0.5 C, excellent cycling stability with a capacity retention of 70% after 500 cycles, and outstanding rate capability, one of the best results among pure carbon hosts. check details The strategy suggested here may rekindle interest in exploring the potential of pure carbon materials for lithium-sulfur batteries as well as other energy storage devices.Polyelectrolyte multilayers (PEMs) are attractive materials for immobilizing enzymes due to their unique ionic environment, which can prevent unfolding. Here, we demonstrated that the stability to dry storage and elevated pH were significantly enhanced when negatively charged nitroreductase (NfsB) was embedded in a PEM by depositing alternating layers of the enzyme and polycation (PC) onto porous silica particles. The PC strength (i.e., pKa) and the surface charge of the film were varied to probe the effects that internal and surface chemistry had on the pH stability of the entrapped NfsB. All films showed enhanced activity retention at elevated pH (>6), and inactivation at reduced pH ( less then 6) similar to NfsB in solution, indicating that the primary stabilizing effect of immobilization was achieved through ionic interactions between NfsB and the PC and not through changes to the surface charge of the NfsB. Additionally, films that were stored dry at 4 °C for 1 month retained full activity, while those sstrate transport.High-energy density solid-state lithium metal batteries are expected to become the next generation of energy storage devices. Polymeric ionic liquid-based solid polymer electrolytes (PIL-based SPEs) are an attractive choice among electrolytes, but their ionic conductivities are generally insufficient due to numerous crystallized polymer regions. To achieve higher conductivity, we use facile copolymerization of an ionic liquid (IL) monomer and poly(ethylene glycol) diacrylate monomer to obtain in situ plasticized polymer chains. The resultant PIL-based SPE exhibits decreased crystallinity, a lower glass-transition temperature, and improved ionic conductivity (1.4 × 10-4 S cm-1 at 30 °C). A solid-state LiFePO4 (LFP)|Li battery based on the SPE displays a high reversible specific capacity of 140 mA h g-1 at 0.2C at 25 °C and excellent cycling stability, accompanying high Coulombic efficiency of approximately 100%. The in situ plasticized PIL-based SPE is significant in developing solid-state Li metal battery systems.Functionalized interfaces enhancing phase-change processes have immense applicability in thermal management. Here, a methodology for fabrication of surfaces enabling extreme boiling heat transfer performance is demonstrated, combining direct nanosecond laser texturing and chemical vapor deposition of a hydrophobic fluorinated silane. Multiple strategies of laser texturing are explored on aluminum with subsequent nanoscale hydrophobization. Both superhydrophilic and superhydrophobic surfaces with laser-engineered microcavities exhibit significant enhancement of the pool boiling heat transfer. Surfaces with superhydrophobic microcavities allow for enhancements of a heat transfer coefficient of over 500%. Larger microcavities with a mean diameter of 4.2 μm, achieved using equidistant laser scanning separation, induce an early transition into the favorable nucleate boiling regime, while smaller microcavities with a mean diameter of 2.8 μm, achieved using variable separation, provide superior performance at high heat fluxes. The enhanced boiling performance confirms that the Wenzel wetting regime is possible during boiling on apparently superhydrophobic surfaces. A notable critical heat flux enhancement is demonstrated on superhydrophobic surfaces with an engineered microstructure showing definitively the importance and concomitant effect of both the surface wettability and topography for enhanced boiling. The fast, low-cost, and repeatable fabrication process has great potential for advanced thermal management applications.