Ochoabrandon3842

Finally, we also examine the interactions of ternary polymer aggregates with model bacterial membranes, which show that replacing some of the hydrophobic groups by polar groups leads to weakly held ternary aggregates enabling them to undergo rapid partitioning and insertion into membrane interior. Our work thus underscores the role of inclusion of polar groups into the framework of traditional binary biomimetic antimicrobial polymers and suggests different mode of partitioning into bacterial membranes, mimicking antimicrobial mechanism of globular antimicrobial peptides like Defensin.Correction for 'Ultra-fast synthesis of water soluble MoO3-x quantum dots with controlled oxygen vacancies and their near infrared fluorescence sensing to detect H2O2' by Shichuan Zhong et al., Nanoscale Horiz., 2020, 5, 1538-1543, DOI 10.1039/D0NH00394H.The dynamics of the wrapping of a charged flexible microfiber around an oppositely charged curved particle immersed in a viscous fluid is investigated. We observe that the wrapping behavior varies with the radius and Young's modulus of the fiber, the radius of the particle, and the ionic strength of the surrounding solution. We find that wrapping is primarily a function of the favorable interaction energy due to electrostatics and the unfavorable deformation energy needed to conform the fiber to the curvature of the particle. We perform an energy balance to predict the critical particle radius for wrapping, finding reasonably good agreement with experimental observations. In addition, we use mathematical modeling and observations of the deflected shape of the free end of the fiber during wrapping to extract a measurement of the Young's modulus of the fiber. We evaluate the accuracy and potential limitations of this in situ measurement when compared to independent mechanical tests.The theoretical optoelectronic properties of chalcogenide perovskites (e.g., BaZrS3) are as good as those of halide perovskites (e.g., CH3NH3PbI3). But the fabrication of optoelectronic devices is rarely reported, mainly because researchers still do not know how to prepare good quality thin films of chalcogenide perovskites. Here, we report colloidal BaZrS3 nanocrystals (NCs, 40-60 nm) and their solution processed thin film transistors. BaZrS3 NCs are first prepared using a solid-state synthesis route, and the subsequent surface modifications lead to a colloidal dispersion of NCs in both polar N-methyl-2-pyrrolidinone and non-polar chloroform solvents. The NCs exhibit good thermal (15-673 K) and aqueous stability. Colloidal BaZrS3 NCs in chloroform are then used to make field effect transistors showing ambipolar properties with a hole mobility of 0.059 cm2 V-1 s-1 and an electron mobility of 0.017 cm2 V-1 s-1. This report of solution processed chalcogenide perovskite thin films with reasonable carrier mobility and optical absorption and emission is expected to pave the way for future optoelectronic devices of chalcogenide perovskites.Noble metal-based catalysts have attracted huge attention owing to their intriguing activity and selectivity. Revealing noble metal active sites and keeping them in a form of stable and high loading are crucial to improving the catalytic performance and understanding the reaction mechanism. Herein, a feasible preparation method was used to synthesize a Rh-based ultrathin NiFe layered double hydroxide (Rh/NiFe). The detailed study proved that the existence form of Rh atoms is atomically dispersed. Moreover, extended X-ray absorption fine structure (EXAFS) with theoretical calculation of X-ray absorption near-edge structure (XANES) and density functional theory (DFT) were used to identify at the atomic level the precise location and coordination environment of the introduced Rh atoms. It was found that Rh atoms are doped in the LDH layer in a coplanar position with Ni and Fe atoms. With a 5.4 wt% loading amount of Rh, the modified catalyst of Rh/NiFe-5.4 requires 80 mV less than unmodified ultrathin NiFe layered double hydroxide (NiFe) for hydrazine electrooxidation. learn more The XAFS fitting revealed that the doping of Rh atoms results in the distortion of the laminate and then introduces certain defects, which may be attributed to electron transport, thus endowing them with exceptional electrocatalytic performance.Graphene-based polymers exhibit a conductive microstructure formed by aggregates in a matrix which drastically enhances their transmitting properties. We develop a new numerical framework for predicting the electrical conductivity based on continuum percolation theory in a two dimensional stochastically-generated medium. We analyze the role of the flake shape and its aspect ratio and consequently predict the onset of percolation based on the particle density and the domain scale. Simultaneously, we have performed experiments and have achieved very high electrical conductivity for such composites compared to other film fabrication techniques, which have verified the results of computing the homogenized electrical conductivity. As well, the proximity to and a comparison with other analytical models and other experimental techniques are presented. The numerical model can predict the composite transmitting conductivity in a larger range of particle geometry. Such quantification is exceedingly useful for effective utilization and optimization of graphene filler densities and their spatial distribution during manufacturing.Pallenis spinosa is a medicinal plant which is used in folk medicine as curative or preventive remedies for various diseases. Individual phenolic compounds from the methanolic extracts of its flowers, leaves and stem were determined by the high performance liquid chromatography method (HPLC) and total phenolic contents (TPC) were evaluated by Folin-Ciocalteu assay. The stability and bioactivity (antioxidant activity, micellar cholesterol solubility, α-amylase, and angiotensin converting enzymes (ACE) inhibitory effects) of these extracts in the gastrointestinal environment was determined before and after their protection in hydroxypropylmethylcellulose (HPMC) capsules. HPLC analysis revealed the presence of thirteen phenolic compounds with nine flavonoids and four phenolic acids. Except for kaempferol, the twelve other compounds have not been previously detected in the aerial part of the studied plant. Quantification of phenolics by HPLC and Folin Ciocalteu methods revealed that the highest TPC was detected in the flower extracts (104.31 ± 0.80 and 145.73 ± 0.48 mg EGA per g of extract, respectively). Leaf extracts displayed the best antioxidant capacity against the two tested radicals DPPH and ABTS (IC50 = 1.24 ± 0.03 and 0.94 ± 0.02 mg mL-1, respectively), FRAP assay (IC50 = 0.50 ± 0.02 mg mL-1), α-amylase inhibitory (IC50 = 1.25 ± 0.00 mg mL-1) and angiotensin activity with an inhibitory percent of 30.10 ± 0.12%. The best activity shown by stem extracts was against micellar cholesterol solubility (67.57 ± 0.00%). A strong decrease in TPC and their bioactivity was observed after the gastrointestinal digestion (GID) in non encapsulated extracts. These results showed that P. spinosa is a good source of phenolic compounds and GID affects significantly their composition, content and bioactivity.Microfluidic technology, as a method for manipulating tiny fluids, has the advantages of low sample consumption, fast reaction, and no cross-contamination. In a microfluidic system, accurate manipulation of droplets is a crucial technology that has been widely investigated. In this work, a self-powered droplet manipulation system (SDMS) is proposed to realize various droplet operations, including moving, splitting, merging, mixing, transporting chemicals and reacting. The SDMS is mainly composed of a triboelectric nanogenerator (TENG), an electric brush, and a microfluidic device. The TENG serves as a high-voltage source to power the system. Using different electric brushes and microfluidic devices, different manipulations of droplets can be achieved. Moreover, by experiments and simulations, the influence of the electrode width, the electrode gap and the central angle of one electrode on the performance of SDMS is analyzed in detail. Firstly, by using electrowetting-on-dielectric (EWOD) technology, SDMS can accurately control droplets for long-distance linear movement and simultaneously control multiple droplets to move in a circular electrode track consisting of 40 electrodes. SDMS can also manipulate two droplets of different components to merge and react. In addition, using dielectrophoresis (DEP) technology, SDMS can separate droplets with maximum volumes of 400 μL and reduce the time of the complete mixing of two droplets with different components by 6.3 times compared with the passive mixing method. Finally, the demonstration shows that a droplet can be manipulated by hand power for chemical delivery and chemical reactions on a circular electrode track without an external power source, which proves the applicability of SDMS as an open-surface microfluidic device. Therefore, the self-powered droplet manipulation system proposed in this work may have great application in the fields of drug delivery, micro chemical reactions, and biological microanalysis.We describe herein a catalyst-free and redox-neutral photochemical strategy for the direct generation of acyl radicals from α-diketones, and its selective conversion of nitrosoarenes to hydroxyamides or amides with AcOH or NaCl as an additive. The reaction was carried out under mild conditions in water with purple LEDs as the light source. A broad scope of substrates was demonstrated. Mechanistic experiments indicate that α-diketones cleave to give acyl radicals, with hydroxyamides being further reduced to amides.Hydroxyapatite (HAP) is promising for the clinical treatment of bone defects because of its excellent biocompatibility and osteo-conductivity. However, highly porous HAP scaffolds usually exhibit high brittleness and poor mechanical properties, thus organic constituents are usually added to form composite materials. In this work, a highly porous and elastic aerogel made from ultralong HAP nanowires with ultrahigh porosity (∼98.5%), excellent elasticity and suitable porous structure is prepared as the high-performance scaffold for bone defect repair. The highly porous structure of the as-prepared aerogel is beneficial to bone ingrowth and matter/fluid transfer, and the high elasticity can ensure the structural integrity of the scaffold during bone regeneration. Therefore, the HAP nanowire aerogel scaffold can promote the adhesion, proliferation and migration of rat bone marrow derived mesenchymal stem cells (rBMSCs), and elevate the protein expression of osteogenesis and angiogenesis related genes. The in vivo experimental results demonstrate that the HAP nanowire aerogel scaffold is favorable for the ingrowth of new bone and blood vessels, and thus can greatly accelerate bone regeneration and neovascularization. The as-prepared HAP nanowire aerogel scaffold shows promising potential for biomedical applications such as bone defect repair.Controlled electrical stimulation is essential for evaluating the physiology of cardiac tissues engineered in heart-on-a-chip devices. However, existing stimulation techniques, such as external platinum electrodes or opaque microelectrode arrays patterned on glass substrates, have limited throughput, reproducibility, or compatibility with other desirable features of heart-on-a-chip systems, such as the use of tunable culture substrates, imaging accessibility, or enclosure in a microfluidic device. In this study, indium tin oxide (ITO), a conductive, semi-transparent, and biocompatible material, was deposited onto glass and polydimethylsiloxane (PDMS)-coated coverslips as parallel or point stimulation electrodes using laser-cut tape masks. ITO caused substrate discoloration but did not prevent brightfield imaging. ITO-patterned substrates were microcontact printed with arrayed lines of fibronectin and seeded with neonatal rat ventricular myocytes, which assembled into aligned cardiac tissues. ITO deposited as parallel or point electrodes was connected to an external stimulator and used to successfully stimulate micropatterned cardiac tissues to generate calcium transients or propagating calcium waves, respectively.