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Older siblings are powerful socialization agents, playing a significant role in the sociocognitive, social, and emotional development of their younger siblings. However, there are few clues about the variables that explain younger sibling's adaptation. The objective of this pilot study was to identify the determinants of younger siblings' adaptation and to analyze the role played by personal, sibling, family and older siblings' variables using 50 dyads of siblings aged between 7 and 18 years. The variables considered were the sibling relationships and the maladaptation of older siblings, and individual (sex, number of siblings, extroversion, and agreeableness) and contextual variables (interparental conflict, daily stress) were controlled. Hierarchical multiple regressions provided evidence in favor of the model that analyzed the younger siblings' maladaptation to school, showing positive associations both with the older siblings' level of school maladaptation and with sibling conflict. In addition, the study highlighted the relevance of the trait of agreeableness and of family stress in the adaptation of younger siblings.The EFSA Panel on Plant Health performed a pest categorisation of Thecodiplosis japonensis (Diptera Cecidomyiidae) for the EU territory. This species is not included in the EU Commission Implementing Regulation 2019/2072. T. japonensis Uchida & Inouye is a well-defined species, native to a large part of Japan, which was introduced to the Republic of Korea and eastern China Fujian and Shandong. It attacks Pinus densiflora, P. thunbergii and P. luchuensis in Japan; P. densiflora and P. thunbergii in Korea; and P. massoniana in China, and has been observed to attack other two-needle pine species, including species present in the EU. The pest is univoltine and the adults emerge between May and August. The adults live only for 1 day. Each female oviposits in batches on developing needles. The neonate larvae crawl to the base of the needle fascicle and create a gall in which they feed gregariously by sap sucking. The third-instar larvae leave the galls in November, overwinter in a cocoon in the soil and pupate at the end of the winter. Degree day models have been developed to predict adult emergence. Survival of overwintering stages is poor below 15°C and above 30°C. The pest can be detected by its symptoms (stunted or dead needles, galls at the base of infected needle fascicles), and identified using morphological characters or the mitochondrial COI gene. T. japonensis is one of the major forest pests in the Republic of Korea, where 1.7 million trees were cut to control it in 2014-2015. It flies uneasily (a few hundred metres) but can be transported in galls on Pinus plants for planting, including artificially dwarfed plants, or with cut branches. Climate matching and host tree distribution suggest that T. japonensis would be able to establish and have an impact in the EU territory. T. japonensis satisfies all the criteria that are within the remit of EFSA to assess for it to be regarded as a potential Union quarantine pest.Rhodococcus equi (R. equi) was identified among the most relevant antimicrobial-resistant (AMR) bacteria in the EU for horses in a previous scientific opinion. Thus, it has been assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7 on disease profile and impacts, Article 5 on its eligibility to be listed, Annex IV for its categorisation according to disease prevention and control rules as in Article 9 and Article 8 for listing animal species related to the bacterium. The assessment has been performed following a methodology previously published. The outcome is the median of the probability ranges provided by the experts, which indicates whether each criterion is fulfilled (lower bound ≥ 66%) or not (upper bound ≤ 33%), or whether there is uncertainty about fulfilment. Reasoning points are reported for criteria with uncertain outcome. According to the assessment here performed, it is uncertain whether AMR R. equi can be considered eligible to be listed for Union intervention according to Article 5 of the AHL (10-66% probability). https://www.selleckchem.com/products/nd-630.html According to the criteria in Annex IV, for the purpose of categorisation related to the level of prevention and control as in Article 9 of the AHL, the AHAW Panel concluded that the bacterium does not meet the criteria in Sections 1 and 2 (Categories A and B; 5-10% and 10-33% probability of meeting the criteria, respectively), and the AHAW Panel is uncertain whether it meets the criteria in Sections 3, 4 and 5 (Categories C, D and E; 10-66% probability of meeting the criteria in all three categories). The animal species to be listed for AMR R. equi according to Article 8 criteria are mainly horses and other species belonging to the Perissodactyla and Artiodactyla orders.In this Opinion, the antimicrobial-resistant bacteria responsible for transmissible diseases that constitute a threat to the health of certain kept fish species have been assessed. Atlantic salmon (Salmo salar), carp (Cyprinus spp.), rainbow trout (Oncorhynchus mykiss), sea bream (Sparus aurata) and tilapia (Oreochromis spp.), selected as representative of the most important fish species and production systems that are commercially reared in fresh and saltwater farms, were the focus of this assessment. The assessment was performed following a methodology based on information collected by an extensive literature review and expert judgement. Details of the methodology used for this assessment are explained in a separate Opinion. The global state of play of antimicrobial resistance in Aeromonas hydrophila, Aeromonas salmonicida, Flavobacterium psychrophilum and Flavobacterium columnare is provided. Among these bacteria, none was identified as being among the most relevant antimicrobial-resistant bacteria in the assessed kept fish species in the EU due to the very limited scientific evidence available.Africa's ecosystems have an important role in global carbon dynamics, yet consensus is lacking regarding the amount of carbon stored in woody vegetation and the potential impacts to carbon storage in response to changes in climate, land use, and other Anthropocene risks. Here, we explore the socio-environmental conditions that shaped the contemporary distribution of woody vegetation across sub-Saharan Africa and evaluate ecosystem response to multiple scenarios of climate change, anthropogenic pressures, and fire disturbance. Our projections suggest climate change will have a small but negative effect on above ground woody biomass at the continental scale, and the compounding effects of population growth, increasing human pressures, and socio-climatic driven changes in fire behavior further exacerbate climate-driven trends. Relatively modest continental-scale trends obscure much larger regional perturbations, with climatic and anthropogenic factors leading to increased carbon storage potential in East Africa, offset by large deficits in West, Central, and Southern Africa.
Pulmonary arterial hypertension (PAH) usually causes right ventricular dysfunction, which is closely related to cardiac fibrosis. But cardiac fibrosis mechanism remains unclear. Our purpose was to explore microRNA-325-3p (miR-325-3p)/human epididymis protein 4's (HE4) role in the occurrence and development of right ventricular fibrosis in PAH.
The right ventricular fibrosis model of rats with PAH was constructed, and miR-325-3p was overexpressed to explore miR-325-3p's effect on myocardial fibrosis in rats with PAH. Pearson correlation coefficient examined the correlation between HE4 and miR-325-3p. We separated and identified the primary rat myocardial fibroblasts from the heart tissue. Then, the Ang II-treated myocardial fibroblast fibrosis model was constructed. miR-325-3p mimics and si-HE4 and oe-HE4 cell lines were constructed to investigate miR-325-3p and HE4 effects on myocardial cell fibrosis. Then, we added PI3K inhibitor LY294002 to study the effects of HE4 in cell fibrosis by the PI3K/AKT pathwis in rats with PAH. This study could provide new targets and strategies for right ventricular fibrosis in PAH.
To systematically evaluate the effect of collaborative nursing on self-care ability of postcolostomy patients with colorectal cancer (CRC).
PubMed, Web of Science, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched to collect relevant literatures on randomized controlled trials of postcolostomy patients with CRC. The search period was started from 2010 to 2021. Statistical analysis was performed on the data extracted from the comprehensive meta-analysis with STATA 16.0 analysis software.
As a result, it was found that the incidence of adverse reactions in the control group was higher than that in the treatment group. Seven studies included the preintervention self-care concept and preintervention self-care skills. Six studies included preintervention self-care responsibility and preintervention exercise of self-care agency (ESCA) scale. In the comparison among the concept of self-care after intervention, self-care skills, self-care responsibility, and ESCA scale, all of them had higher scores in the treatment group than in the control group (
< 0.05). It fully explains that collaborative nursing can significantly improve the evaluation indicators of patients' self-care ability and reduce patient complications.
The application of collaborative nursing in the nursing work of patients with CRC after colostomy can significantly reduce the incidence of adverse nursing reactions.
The application of collaborative nursing in the nursing work of patients with CRC after colostomy can significantly reduce the incidence of adverse nursing reactions.
To investigate the manipulative reduction in abnormal uterine inclination in vaginal delivery.
With the independently developed uterine inclination surveyor, 40 primiparas with abnormal uterine inclination were randomly divided into two groups treatment group (Group A, 20 cases) and control group (Group B, 20 cases). The general condition of the primipara, the labor stages, the changes in uterine inclination after treatment, postpartum hemorrhage at 2 hours, and the general condition of fetuses were observed to study the therapeutic value of manual reduction in abnormal uterine inclination.
In the control group, one uterine inclination was not corrected with the change in labor process, and the pregnancy was terminated due to stagnation of the active phase. In the first stage of labor, the time spent in the treatment group (393.4 ± 31.3 mins) was significantly lower than that in the control group (440.7 ± 34.9 mins) (
= 0.001). Compared with the control group (49.8 ± 6.5 mins), the treatment group (42.6 ± 7.2 mins) also exhibited a significantly shortened second stage of labor (
= 0.02). Sixteen cases (16/20) in the treatment group returned to normal after manual reduction, and 9 cases (9/20) in the control group returned to normal with the progression of natural labor. Manual reduction could be used as an option to treat abnormal uterine inclination (
= 0.01). There was no significant difference in the third stage of labor (
= 0.2), 2-hour postpartum hemorrhage (
= 0.35), Apgar score (
= 0.64), or body weight (
= 0.76) between the two groups.
Manual reduction in the treatment of abnormal uterine inclination has obvious effects, shortens the birth process, and is safe for the fetus.
Manual reduction in the treatment of abnormal uterine inclination has obvious effects, shortens the birth process, and is safe for the fetus.
