Nygaardbyers3805

RESULTS In multivariable-adjusted analyses, we observed a 40% higher XFG risk with any non-melanoma skin cancer history (MVRR=1.40; 95% CI=1.08,1.82); the association was observed even with 4 and 8 year lags in non-melanoma skin cancer history. Also, the non-melanoma skin cancer association was stronger in younger ( less then 65▒y; MVRR=2.56; 95% CI=1.62,4.05) versus older participants (≥65▒y; MVRR=1.25; 95% CI=0.94,1.66; p for interaction=0.01) and those living in northern latitudes (≥42° north; MVRR=1.92; 95% CI=1.28,2.88) versus more southern latitudes ( less then 42° north; MVRR=1.19; 95% CI=0.86,1.66; p for interaction=0.04). CONCLUSIONS Non-melanoma skin cancer was associated with higher XFG risk, particularly among younger participants and those living in Northern US.PRéCIS Gel stent implantation is a bleb-forming surgery designed to achieve predictable pressure drop. MC3 An early low intraocular pressure is associated with the long-term success of the procedure. PURPOSE To identify the variables associated with the success of the XEN procedure. PATIENTS AND METHODS This was part of a prospective, uncontrolled, consecutive case series study. Patients with primary open-angle glaucoma or pseudo-exfoliative glaucoma were included. All the patients underwent surgical Xen implant procedure with MMC subconjunctival injection 20 minutes before surgery. Success criteria were an off-medication IOP of 6 to 16▒mmHg 12 months after surgery; no additional glaucoma surgery; no visual threatening complications, no visual acuity loss greater than 1 Snellen line. One eye per patient was considered for statistical analysis. A univariate Cox's proportional hazard regression analysis was performed to identify potential risk factors for surgical failure. Then, a multivariate cox model was built. RESULTS 123 patients were recruited in this study 93 patients underwent Xen implantation alone whereas 30 the combined procedure with phacoemulsification and IOL implantation. Univariate cox regression showed that the day after surgery IOP greater than 9▒mmHg was associated with surgical failure (P=0.02) and a postoperative number of needlings greater or equal to 2 in the follow-up was also predictive of surgical failure (P less then 0.01). These data were confirmed by a multivariate model too. At 1-year the surgical success criteria were 76% in the group with 24-hour IOP below or equal to 9▒mmHg, while it was 43% when above 9▒mmHg (P=0.026). CONCLUSION Our study shows that an early IOP below or equal to 9▒mmHg is predictive of the efficacy of the procedure during 1-year follow-up, while more than two needlings are predictive of failure.PURPOSE To determine the correlation and agreement between IOP parameters evaluated by the modified diurnal tension curve (mDTC) and the water drinking test (WDT) in primary open-angle glaucoma (POAG) in an indigenous African population. MATERIALS AND METHODS This was a prospective, interventional, comparative study of 50 newly- diagnosed, previously untreated POAG patients at the out-patient clinic of the Eleta Eye Institute, Ibadan. A series of IOP measurements were taken 2-hourly (from 700 am to 300 pm) for the mDTC, using Goldmann applanation tonometer (GAT). The water drinking test was performed thereafter. The patients drank 800▒mL of water within 5 minutes, and another series of IOP measurements were taken every 15 minutes for a duration of 1 hour from the moment water was fully ingested. Both the mDTC and the WDT were performed on the same day. IOP peak, mean and IOP fluctuations were estimated from the data collected. Comparison between the mDTC and the WDT was performed using the paired students T-t with limited personnel, time and resource constraints. In addition, higher IOP values were obtained from the WDT compared to the mDTC, and therefore could serve as a useful practical way to determine target peak in order to optimize IOP control in glaucoma patients.BACKGROUND The aim of this systematic review and meta-analysis was to evaluate whether computed tomography (CT) scan adds any diagnostic value in the evaluation of stab wounds of the anterior abdominal wall as compared with serial clinical examination (SCE). METHODS PubMed, EMBASE, Cochrane Library, and MEDLINE via Ovid were systematically searched for records published from 1980 to 2018 by two independent researchers (M.G., R.L.). Quality assessment, data extraction, and analysis were performed according to the Cochrane Handbook for Systematic Reviews of Interventions. Mantel-Haenszel method with odds ratio (OR) and 95% confidence interval (95% CI) as the measure of effect size was used for meta-analysis. RESULTS Three studies (1 randomized controlled trial and 2 observational studies) totaling 319 patients were included in the meta-analysis. Overall laparotomy rate was 12.8% (22 of 172 patients) in SCE versus 19% (28 of 147 patients) in CT. This difference was not significant (OR [95% CI], 0.63 [0.34-1.16]; p = 0.14). Negative laparotomy rate was 3.5% (6 of 172 patients) in SCE versus 5.4% (8 of 147 patients) in CT. The difference was not significant (OR [95% CI], 0.61 [0.20-1.83]; p = 0.37). CONCLUSION This meta-analysis compared SCE with CT scan in patients presenting with stab wounds of the anterior abdominal wall and provided level II evidence showing no additional benefit in CT scan. Further observational and experimental clinical studies are needed to confirm the findings of this meta-analysis. LEVEL OF EVIDENCE Systematic review and meta-analysis, level II.BACKGROUND Frailty is a risk factor for mortality among the elderly. However, evidence from longitudinal studies linking trauma and frailty is fragmented, and a comprehensive analysis of the relationship between frailty and adverse outcomes is lacking. Therefore, we conducted a systematic review and meta-analysis to examine whether frailty is predictive of posttraumatic results including mortality, adverse discharge, complications, and readmission in trauma patients. METHODS This systematic review was registered with the PROSPERO international prospective register of systematic reviews. Articles in PubMed, Embase, and Web of Science databases from January 1, 1990, to October 31, 2019, were systematically searched. Articles in McDonald et al.'s study (J Trauma Acute Care Surg. 2016;80(5)824-834) and Cubitt et al.'s study (Injury 2019;50(11)1795-1808) were included for studies evaluating the association between frailty and outcomes in trauma patients. Cohort studies, both retrospective and prospective, were included.