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Children with cancer often develop leukopenia which may impair wound healing and increase surgical complication rates. When leukopenic children with cancer develop an acute surgical condition, the optimal management strategy remains unclear. This study examined the effect of preoperative leukopenia on postoperative outcomes in children with cancer who underwent an appendectomy or cholecystectomy.

We retrospectively identified cancer patients undergoing an appendectomy or cholecystectomy from the National Surgical Quality Improvement Program-Pediatric database from 2012-2018. Demographics and perioperative characteristics were compared by leukopenia status (WBC <4 vs. ≥4×10^3/mL). Postoperative length of stay (LOS) and 30-day composite complications, including infections, reoperations, and readmissions, were analyzed for each procedure using multivariate regression.

There were 227 children who underwent an appendectomy and 101 children who underwent a cholecystectomy. Leukopenia was seen in 93 (41.0%)s not associated with increased short-term postoperative complications or longer postoperative LOS after either an appendectomy or cholecystectomy. These results support that operative management can be performed safely in pediatric appendicitis and cholecystitis in leukopenic cancer patients.

To assess the mechanical contribution of inner eye components on corneal deformation during a finite element analysis.

A finite element model of an eye globe was implemented to examine the corneal response under various mechanical conditions. The model incorporates the cornea, limbus, sclera, iris, lens, muscles, anterior chamber and vitreous. The Ogden hyperelastic model was used for the corneo-limbal region and the Yeoh isotropic model for the sclera. The anterior chamber was modelled as a cavity and other eye components were incorporated as linear elastic material. A fluid dynamic simulation was implemented to determine the spatial air puff velocity and pressure profiles around corneal surface.

The maximal apical displacement under IOP= 15mmHg was 0.22mm with a stress of 0.013MPa. An unrestrained limbus slightly increases the apical displacement, while an unrestrained equatorial sclera largely increases the displacement by 10%, resulting in reduced stiffness. The iris slightly decreases the displacement but increases stress in the corneal periphery. Meanwhile, the joint contribution of muscle and lens cannot be neglected as it reduces corneal displacement by 50%. Incorporation of the remaining eye components results in nearly similar results. Under air puff loading, a free equatorial sclera raised the dynamic deformation amplitude by nearly 2%, while the dynamic profile remained similar for all remaining study cases considered.

In a finite element analysis, the lens, iris, and muscle each provide major mechanical contributions to corneal deformation, and it is highly recommended that the internal contributions are considered.

In a finite element analysis, the lens, iris, and muscle each provide major mechanical contributions to corneal deformation, and it is highly recommended that the internal contributions are considered.Cisplatin is a DNA-damaging chemotherapeutic agent used for treating cancer. Based on cDNA dataset analysis, we investigated how cisplatin modified gene expression and observed cisplatin-induced dysregulation and system-level variations relating to insulin resistance and type 2 diabetes mellitus (T2DM). T2DM is a multifactorial disease affecting 462 million people in the world, and drug-induced T2DM is a serious issue. To understand this etiology, we designed an integrative, system-level study to identify associations between cisplatin-induced differentially expressed genes (DEGs) and T2DM. From a list of differential expressed genes, cisplatin downregulated the cyclin-dependent kinase inhibitor 1 (CDKN1A), tumor necrosis factor (FAS), and sestrin-1 (SESN1) genes responsible for modifying signaling pathways, including the p53, JAK-STAT, FOXO, MAPK, mTOR, P13-AKT, Toll-like receptor (TLR), adipocytokine, and insulin signaling pathways. These enriched pathways were expressively associated with the disease. We observed significant gene signatures, including SMAD3, IRS, PDK1, PRKAA1, AKT, SOS, RAS, GRB2, MEK1/2, and ERK, interacting with source genes. This study revealed the value of system genetics for identifying the cisplatin-induced genetic variants responsible for the progression of T2DM. Also, by cross-validating gene expression data for T2DM islets, we found that downregulating IRS and PRK families is critical in insulin and T2DM signaling pathways. Cisplatin, by inhibiting CDKN1A, FAS, and SESN1, promotes IRS and PRK activity in a similar way to rosiglitazone (a popular drug used for T2DM treatment). Our integrative, network-based approach can help in understanding the drug-induced pathophysiological mechanisms of diabetes.Descriptions of resilient performance in healthcare services usually emphasize the role of skills and knowledge of caregivers. At the same time, the human factors discipline often frames digital technologies as sources of brittleness. This paper presents an exploratory investigation of the upside of ten digital technologies derived from Healthcare 4.0 (H4.0) in terms of their perceived contribution to six healthcare services and the four abilities of resilient healthcare monitor, anticipate, respond, and learn. This contribution was assessed through a multinational survey conducted with 109 experts. selleck Emergency rooms (ERs) and intensive care units (ICUs) stood out as the most benefited by H4.0 technologies. That is consistent with the high complexity of those services, which demand resilient performance. Four H4.0 technologies were top ranked regarding their impacts on the resilience of those services. They are further explored in follow-up interviews with ER and ICU professionals from hospitals in emerging and developed economies to collect examples of applications in their routines.Recent research has developed two eye-controlled highlighting techniques, namely, block highlight display (BHD) and single highlight display (SHD), that enhance information presentation based on a user's current gaze position. The present research aimed to investigate how these techniques facilitate mental processing of users' visual search in high information-density visual environments. In Experiment 1, 60 participants performed 3-, 6-, 9-, and 12-icon visual search tasks. The search times significantly increased as the number of icons increased with the SHD but not with the BHD. In Experiment 2, 40 participants performed a 49-icon visual search task. The search time was faster, and the fixation spatial density was lower with the BHD than with the SHD. These results suggested that the BHD supported parallel processing in the highlighted area and serial processing in the broader display area; thus, the BHD improved search performance compared to the SHD, which primarily supported serial processing.