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05). CONCLUSION The lead and high fat diet have resulted in the lipid metabolism disorders and impair the cognitive function and central nervous system by promoting the secretion of inflammatory factors in glial cells, inducing the inflammatory reaction of brain tissue, inhibiting GSH-ST expression and increasing AGEs content. OBJECTIVE Before January 2019, no established solutions regarding the screening, assessment, and treatment of patients suffering from perinatal depression existed in Poland. From 2019, a new standard of perinatal care has imposed the obligation to monitor the mental state of women during pregnancy and in the postpartum period on the healthcare providers (mainly on midwives). Thus, our study aimed to evaluate midwives' knowledge about prenatal and postnatal mental health disorders in the first six months of implementing the new standard of perinatal care in Poland. DESIGN Polish midwives completed a survey consisting of the Test of Antenatal and Postpartum Depression Knowledge by Jones, Creedy, and Gamble (2001) and questions related to a hypothetical case study of a depressed woman named "Mary", developed by Buist and colleagues (2006). The midwives also rated their perceived knowledge and skills in assessing women' mental health condition. SETTING The study was conducted in four Polish cities Gdansk, Olsztyn, Szczecin, Wroclaw, and the surrounding rural areas. PARTICIPANTS 111 Polish midwives with varied professional experience and socio-demographic characteristics participated in the study. MEASUREMENTS AND FINDINGS Among all of their professional responsibilities, the midwives self-rated their knowledge and skills in assessing the mental state of patients as the lowest ones. A subsequent objective assessment revealed their insufficient knowledge about antenatal and postnatal depression and the ways of treatment of these disorders. KEY CONCLUSIONS Midwives are not properly prepared for the new tasks resulting from the Polish standard of perinatal care specifically, for the assessment of a woman's mental state. IMPLICATIONS FOR PRACTICE Further trainings are required to ensure midwives' competency and knowledge about the assessment and dealing with mental disorders of patients who experience prenatal and postpartum depression. BACKGROUND Aim of our study was to identify conditions under which malaria transmission caused by imported infectious mosquitoes or travellers could occur at large central European airports, and if such transmission could be sustained by indigenous mosquitoes. METHODS We developed a deterministic and a stochastic compartmental Susceptible-Exposed-Infectious-Recovered-Susceptible (humans)/Susceptible-Exposed-Infectious (mosquitoes) model with two mosquito (imported Anopheles gambiae, indigenous A. plumbeus) and three human (travellers, airport personnel exposed/not exposed to imported A. gambiae) populations. We assessed various scenarios to identify combinations of model parameters leading to ongoing malaria transmission at the airport. RESULTS The number of infected airport personnel was low (five infected employees/six months) under assumptions reflecting possible future climatic conditions, current passenger mobility and no desinsection of airports/aircraft. Almost all infections among airport personnel were directly due to bites by imported A. gambiae. Indigenous mosquitoes would need to have comparable transmission parameters to A. gambiae to sustain disease transmission. Incoming infectious passengers play only a minor role in malaria transmission. Use of aircraft/airport desinsection led to no transmission events in the model. CONCLUSION Our study shows that sustainable air travel-induced malaria transmission in central Europe is unlikely under current conditions or conditions which might become realistic in the next century. Over the past two decades, several countries in Latin American, particularly Brazil, Venezuela, and Colombia, have experienced multiple outbreaks of oral Chagas disease. Transmission occurs secondary to contamination of food or beverages by triatomine (kissing bug) feces containing infective Trypanosoma cruzi metacyclic trypomastigotes. Orally transmitted infections are acute and potentially fatal. Oral Chagas transmission carries important clinical implications from management to public health policies compared to vector-borne transmission. This review aims to discuss the contemporary situation of orally acquired Chagas disease, and its eco-epidemiology, pathogenesis, and clinical management. We also propose preventive public health interventions to reduce the burden of disease and provide important perspectives for travel medicine. Travel health advisors need to counsel intending travellers to South America on avoidance of "deadly feasts" - risky beverages such as fruit juices including guava juice, bacaba, babaçu and palm wine (vino de palma), açai pulp, sugar cane juice and foodstuffs such as wild animal meats that may be contaminated with T. cruzi. PURPOSE To test whether the whole-tumor radiomics analysis of DKI and DTI images could predict IDH and MGMTmet genotypes of astrocytomas. METHOD Sixty-two astrocytomas were enrolled. 364 radiomics features of whole tumor were extracted from mean-kurtosis (MK), and mean-diffusivity (MD) images, respectively. The multivariable logistic regression was used to select the most meaningful radiomics features for predicting IDH and MGMTmet genotypes. A radiomics model was built by logistic linear regression. A combined model was established based on selected radiomic, radiological and clinical features. To assess the difference between the models, the Z-test was performed. RESULTS The radiomics model built using the three most informative radiomics features for each genotype yielded an AUC of 0.831 ((95 % confidence interval [CI] 0.721-0.918) for predicting IDH genotype, and 0.835 (95 %CI 0.686-0.951) for MGMTmet genotype. MAPK inhibitor A combined model for predicting IDH based on the radiomics score, age, and degree of edema reached an AUC of 0.885 (95 %CI 0.802-0.955) and a combined model for predicting MGMTmet based on radiomics score and edema degree reached an AUC of 0.859 (95 %CI 0.751-0.945) which was not significantly higher than the radiomics only model (P =  0.081). CONCLUSIONS The radiomics models via an objective whole-tumor analysis of MK and MD maps were independent imaging biomarkers for predicting IDH and MGMTmet genotypes, and the combined model further improved the performance for IDH, but not for MGMTmet. V.