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the efficiency of care delivery. Geriatr Gerontol Int 2021; 21 623-628.

Public involvement in research to improve data quality and to empower different stakeholders is good scientific practice, but rarely implemented across all research phases.

This article reports on an attempt to involve members of a self-help group for relatives of people living with dementia as co-researchers in the data analysis in a short-term format.

One researcher identified statements about assistive technologies from 17 interviews with people living with dementia and informal caregivers. Two researchers and six co-researchers independently assigned pre-defined values to these statements. Subsequently, we compared the values of the researchers and co-researchers.

The members of the self-help group identified four original values not considered by the researchers consent, inclusion, participation and respect.

The involvement of co-researchers led to an improvement in the depth of data quality through the joint identification of values concerning assistive technology. Language barriers between researchers, co-researchers and interview participants impeded the data analysis.

The challenges and benefits of a participatory data analysis shown here can provide a basis for recommendations for target group-specific research involvement. Our recommendations relate to the recruitment of co-researchers, requirements for conducting a participatory data analysis and the participation degree of people involved.

The group of co-researchers participating in the data analysis consisted of relatives of people living with dementia.

The group of co-researchers participating in the data analysis consisted of relatives of people living with dementia.In several neurodegenerative diseases, the presence of aggregates of specific proteins in the brain is a significant pathological hallmark; thus, developing ligands able to bind to the aggregated proteins is essential for any effort related to imaging and therapeutics. Here we report the synthesis of thiophene-based ligands containing nitrogen heterocycles. The ligands selectively recognized amyloid-β (Aβ) aggregates in brain tissue from individuals diagnosed neuropathologically as having Alzheimer's disease (AD). The selectivity for Aβ was dependent on the position of nitrogen in the heterocyclic compounds, and the ability to bind Aβ was shown to be reduced when introducing anionic substituents on the thiophene backbone. Our findings provide the structural and functional basis for the development of ligands that can differentiate between aggregated proteinaceous species comprised of distinct proteins. These ligands might also be powerful tools for studying the pathogenesis of Aβ aggregation and for designing molecules for imaging of Aβ pathology.

A randomized controlled trial (RCT) of stratified care demonstrated superior clinical outcomes and cost-effectiveness for low back pain (LBP) patients in UK primary care. This is the first study in Europe, outside of the original UK study, to investigate the clinical efficacy and cost-effectiveness of stratified care compared with current practice for patients with non-specific LBP.

The study was a two-armed RCT. Danish primary care patients with LBP were randomized to stratified care (n=169) or current practice (n=164). Primary outcomes at 3- and 12-months' follow-up were Roland Morris Disability Questionnaire (RDMQ), patient-reported global change and time off work. Secondary outcomes included pain intensity, patient satisfaction, healthcare resource utilization and quality-adjusted life years.

Intention-to-treat analyses found no between-group difference in RMDQ scores at 3months (0.5, 95% CI -1.8 to 0.9) or 12months (0.4, -2.1 to 1.3). No overall differences were found between the arms at 3 and 12moied care for low back pain based on risk profile is recommended by recent evidence based clinical guidelines. This study is the first broad replication of the STarT Back Trial in Europe. Therefore, the study adds to the body of knowledge evaluating the effectiveness of stratified care for low back pain in primary care, and provides insight into the effects of stratification on clinical practice.Understanding the mechanisms that underlie chromosome evolution could provide insights into the processes underpinning the origin, persistence and evolutionary tempo of lineages. Here, we present the first database of chromosome counts for animals (the Animal Chromosome Count database, ACC) summarizing chromosome numbers for ~15,000 species. We found remarkable a similarity in the distribution of chromosome counts between animals and flowering plants. Nevertheless, the similarity in the distribution of chromosome numbers between animals and plants is likely to be explained by different drivers. For instance, we found that while animals and flowering plants exhibit similar frequencies of speciation-related changes in chromosome number, plant speciation is more often related to changes in ploidy. By leveraging the largest data set of chromosome counts for animals, we describe a previously undocumented pattern across the Tree of Life-animals and flowering plants show remarkably similar distributions of haploid chromosome numbers.

Health-care providers increasingly have to discuss uncertainty with patients. Awareness of uncertainty can affect patients variably, depending on how it is communicated. To date, no overview existed for health-care professionals on how to discuss uncertainty.

To generate an overview of available recommendations on how to communicate uncertainty with patients during clinical encounters.

A scoping review was conducted. Four databases were searched following the PRISMA-ScR statement. selleck Independent screening by two researchers was performed of titles and abstracts, and subsequently full texts.

Any (non-)empirical papers were included describing recommendations for any health-care provider on how to orally communicate uncertainty to patients.

Data on provided recommendations and their characteristics (eg, target group and strength of evidence base) were extracted. Recommendations were narratively synthesized into a comprehensible overview for clinical practice.

Forty-seven publications were included. Recommendations were based on empirical findings in 23 publications.