Neergaardkarlsson3756

Traumatic stress is associated with risk of psychiatric and physical illnesses. However, the differential and separable effects of past versus recent traumas on maladaptive coping and neural responses are not known. We conducted two studies to assess separate and combined effects of cumulative recent and past trauma on health outcomes (study 1) and on neural responses to acute stress exposure in a subsample of individuals (study 2). Study 1 assessed a large cohort of 677 community adults cross-sectionally, and findings indicated that both high recent (within the last 12 months) and past trauma (prior to the last twelve months) were associated with more physical and psychological symptoms, including increased depression (all p's less then .05). However, recent trauma alone was associated with higher problematic alcohol use, a greater maximum number of alcohol drinks consumed, greater emotional eating scores, higher state and trait anxiety scores, and poorer lifestyle habits (all p's less then .05). Past trauma alone was associated with higher BMI, decreased social support, and a lower average cortisol relative to ACTH ratio (all p's less then .02). Study 2 involving a functional brain scan on a subsample (N = 75) indicated greater recent trauma was associated with a hyperactive response in the ventromedial prefrontal cortex (VmPFC) to neutral-relaxed exposure, but blunted VmPFC response to acute stress exposure (p  less then  .05 whole brain corrected-WBC). By contrast, high past trauma was associated with a hyper-sensitized neural response to stress in the cortico-limbic-striatal regions (p  less then  .05, WBC) critical for reward and emotion processing. Together, these findings suggest differential neurobehavioral and health effects of cumulative past versus recent trauma exposure.1. Two series of studies were conducted to determine the effects of a combination of ground plant material derived from Quillaja saponaria trees and Yucca schidigera plants (QY) as sources of saponin, on performance, productivity, nutrient digestibility and ileal morphology of growing broilers. In each trial, 480 Cobb male birds were allocated equally to 24 pens at one-day-of-age according to body weight2. The studies consisted of two identical floor pen trials in which performance and nutrient digestibility were assessed and two trials where performance and ileal morphology were determined. In each trial, 0, 250 or 500 ppm QY were included in feed given to the broilers from 1-35 or 1-42 d of age, respectively. Eight (digestibility) or 12 (morphology) randomised replicate pens were used.3. In the digestibility trials, two birds per pen were moved to metabolism cages at d 21. Excreta was collected for a five-day period (d 21 to 25) for the determination of apparent total tract digestibility of dry and organic matter, fat and ash and nitrogen retention. For intestinal morphology, ileal segments were collected from four birds/pen on d 21 to determine villus height and crypt depth. Performance data were collected in each trial series.4. Results showed that feeding graded levels of QY produced significant linear improvements in performance and productivity at d 35, and similar linear effects were observed for N retention and all apparent digestibility measurements. Morphology data showed that birds receiving 250 and 500 ppm QY had significantly increased villus height5. These results indicated that QY exerted a positive influence on the intestinal tract by increasing the absorptive surface and improving nutrient digestibility. These effects were considered to be associated with the performance improvements recorded in both experiments.Sexual scripts and consent communication methods are seldom explored outside of heterosexual, cisgender relationships. To date, little research has been conducted to determine how sexual and gender minority (SGM) students conceptualize and communicate consent. This study explored SGM undergraduate students' (n = 81) sexual consent communication scripts using open-ended survey items. We conducted a thematic freelisting analysis to assess the domains of consent and non-consent scripts using Smith's Salience Score (S). Salient indicators of consent were verbal communication (S = .31; 38%); however, more specific forms of verbal communication were listed as a spectrum, including asking (a request, S = .16; 23%), saying (a statement, S = .16; 20%), and telling (a command, S = .10; 13%). The most salient indicators of verbal non-consent were on a similar spectrum saying no (S = .42; 9%), verbal communication broadly (S = .23; 27%), and telling no (S = .06; 7%). Salient physical indicators of both consent and non-consent also followed a spectrum in their descriptions. Future research among SGM college students should explore the meanings, patterns, and differences in consent communication and sexual scripts.Alzheimer's disease is an increasingly prevalent neurological disorder with no effective therapies. Thus, there is a need to characterize the progression of Alzheimer's disease risk in order to preclude its inception in patients. Characterizing Alzheimer's disease risk can be accomplished at the population-level by the space-time modeling of Alzheimer's disease incidence data. In this paper, we develop flexible Bayesian hierarchical models which can borrow risk information from conditions antecedent to Alzheimer's disease, such as mild cognitive impairment, in an effort to better characterize Alzheimer's disease risk over space and time. From an application of these models to real-world Alzheimer's disease and mild cognitive impairment spatiotemporal incidence data, we found that our novel models provided improved model goodness of fit, and via a simulation study, we demonstrated the importance of diagnosing the label-switching problem for our models as well as the importance of model specification in order to best capture the contribution of time in modeling Alzheimer's disease risk.In much of the Greater Mekong Sub-region, malaria is now confined to patches and small foci of transmission. Malaria transmission is seasonal with the spatiotemporal patterns being associated with variation in environmental and climatic factors. signaling pathway However, the possible effect at different lag periods between meteorological variables and clinical malaria has not been well studied in the region. Thus, in this study we developed distributed lagged modelling accounting for spatiotemporal excessive zero cases in a malaria elimination setting. A multivariate framework was also extended to incorporate multiple data streams and investigate the spatiotemporal patterns from multiple parasite species via their lagged association with climatic variables. A simulation study was conducted to examine robustness of the methodology and a case study is provided of weekly data of clinical malaria cases at sub-district level in Thailand.