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05). Education level, marital status, economic status, complications, treatment options and levels of TNF-α, IL-6, and IL-8 were independent risk factors affecting perioperative anxiety and depression.

There are many factors affecting the perioperative treatment compliance, anxiety and depression of elderly patients undergoing ophthalmic surgery. Effective intervention measures should be taken to improve patients' compliance, reduce their negative emotions, and improve the surgical efficacy.

There are many factors affecting the perioperative treatment compliance, anxiety and depression of elderly patients undergoing ophthalmic surgery. Effective intervention measures should be taken to improve patients' compliance, reduce their negative emotions, and improve the surgical efficacy.

The global outbreak of the coronavirus disease 2019 (COVID-19) has emerged as a major public health threat. This study aimed to analyze the influencing factors of international students' intention to wear a mask based on the theory of planned behavior (TPB). The findings are important because they provide pertinent information in designing and implementing COVID-19 prevention programs.

Self-designed questionnaires were distributed to 477 international students. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) was conducted to identify and confirm the factor structure, and the structural equation model (SEM) was applied to determine the predictors of masks wearing.

The final structural model was well reflected by fit indices. The research model of international students' intention to wear a mask for protection against COVID-19 was acceptable. All of the hypotheses were supported. Attitude and perceived behavioral control (PBC) were positively related to behavior intention (BI), respectively. Subjective norm (SN) also had a direct effect on attitude, PBC, and BI.

Referring to TPB was useful in identifying determinants of mask-wearing. The strongest predictor was SN, which indicated it was deserving of increased attention. These findings are significant to strengthen international students' awareness regarding self-protection and enhance the effectiveness of COVID-19 prevention programs.

Referring to TPB was useful in identifying determinants of mask-wearing. The strongest predictor was SN, which indicated it was deserving of increased attention. These findings are significant to strengthen international students' awareness regarding self-protection and enhance the effectiveness of COVID-19 prevention programs.

With the advances in immune checkpoint inhibitor therapy, several novel treatment options for metastatic renal cell carcinoma (mRCC) patients have recently emerged. The present study explored the optimal first-line immunotherapy for mRCC through a Bayesian network meta-analysis of the latest research data.

PubMed, MEDLINE, EMBASE, American Society of Clinical Oncology (ASCO) meeting abstracts, and the Cochrane Library were searched up to July 2020 to identify any randomized controlled trials related to immunotherapy in the first-line treatment of mRCC. The primary outcome was progressionfree survival, and the secondary outcomes were overall survival and grade 3-4 adverse events.

The network meta-analysis included 4,049 patients from 5 randomized controlled trials. Avelumab plus axitinib and pembrolizumab plus axitinib were the best treatment options in terms of progression-free survival. For overall survival, pembrolizumab plus axitinib had a 77.89% probability of being the preferred treatment. learn more For adverse events, there was an 89.21% probability that pembrolizumab plus axitinib was the regimen with the worst side effects.

Through a meta-analysis of the latest available first-line immunotherapy progression-free survival and overall survival data for mRCC, this study found that pembrolizumab plus axitinib might be the best immunotherapy option for first-line treatment. However, attention should be paid to the potential adverse events of this regimen.

Through a meta-analysis of the latest available first-line immunotherapy progression-free survival and overall survival data for mRCC, this study found that pembrolizumab plus axitinib might be the best immunotherapy option for first-line treatment. However, attention should be paid to the potential adverse events of this regimen.

The nurse's specific understanding of pulmonary rehabilitation is not clear. The aim of the present study was to analyze the cognitive status of Shanghai nurses on pulmonary rehabilitation, and to provide a basis for the development of pulmonary rehabilitation work.

The cognitive status of pulmonary rehabilitation of nursing staff in Shanghai was investigated in the form of a questionnaire. The questionnaire included three main aspects of the function, content and indication of pulmonary rehabilitation, with 10 options for each aspect. The total score was 30 points, with 0-17 points indicating a low score and 18-30 points indicating a high score.

A total of 960 valid questionnaires were collected. The average score of pulmonary rehabilitation knowledge was 18.48 points, with a median of 19 [14-23] points. There were statistically significant differences in the total scores of pulmonary rehabilitation knowledge among nurses of different ages, types of hospitals, levels of hospitals, education levels, proinsufficient understanding of the specific content of lung rehabilitation; therefore, there is room for improvement. More opportunities to develop understanding of pulmonary rehabilitation theory should be provided.

More than half of the nurses surveyed in Shanghai scored high on the cognition of lung rehabilitation knowledge, but there were still many nurses who had poor theoretical knowledge of lung rehabilitation and had an insufficient understanding of the specific content of lung rehabilitation; therefore, there is room for improvement. More opportunities to develop understanding of pulmonary rehabilitation theory should be provided.

High-sensitivity C-reactive protein (hs-CRP) as a prognostic factor of stroke has been proposed and studied. However, the relationship between hs-CRP levels and outcomes among patients with cardioembolic stroke (CES) remains unclear. This study aimed to evaluate the association between hs-CRP levels in the acute phase of CES and poor patient outcomes.

We recruited 478 patients with first-onset CES. Hs-CRP and other biochemical markers were measured within 24 h after admission. Hs-CRP levels were grouped into quartiles (<2.31, 2.31 to <6.09, 6.09 to <22.30, and ≥22.30 mg/L). Stroke severity was assessed using the modified Rankin scale (mRS), with mRS scores of 0 to 2 classified as a good outcome, and scores of 3 to 6 as a poor outcome. Composite endpoints included poor outcomes, vascular death, myocardial infarction (MI), and recurrent stroke (ischemic or hemorrhagic). At 3-month and 1-year follow-ups, we used multivariate logistic regression analysis to assess the relationship between baseline hs-CRP levels, mRS scores, and composite endpoints.