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Dr. Bert Sakmann (b. 1942) studied at the Universities of Tuebingen, Freiburg, Berlin, Paris, and Munich, graduating in 1967. Much of his professional life has been spent in various institutes of the Max Planck Society. In 1971, a British Council Fellowship took him to the Department of Biophysics of University College London to work with Bernard Katz (1911-2003). In 1974, he obtained his Ph.D. from the University of Goettingen and, with Erwin Neher (b. 1944) at the Max Planck Institute for Biophysical Chemistry, began work that would transform cellular biology and neuroscience, resulting in the 1991 Nobel Prize for Physiology or Medicine. In 2008, Dr. Sakmann returned to Munich, where he headed the research group "Cortical Columns in Silico" at the Max Planck Institute of Neurobiology in Martinsried. Here, their group discovered the cell-type specific sensory activation patterns in different layers of a column in the vibrissal area of rodents' somatosensory cortices.Although the concept of clinical education wards has shown encouraging outcomes regarding nursing students' satisfaction with clinical placements in somatic care, the existing research in a psychiatric context is sparse. This study aims to explore nursing students' experience during clinical education at a psychiatric clinical education ward. A qualitive descriptive study with content analysis, using interviews with 16 bachelor's degree nursing students was conducted. The results indicated that an enriched and adapted learning environment focusing on psychiatric nursing with peer learning supported independence and progression into the future nursing role.Mental health care professionals are at risk of experiencing burnout. This cross-sectional study aims to investigate burnout in two settings open and closed psychiatric wards, and two professions registered nurses and social healthcare assistants in eight psychiatric wards in Denmark. ABBV-744 supplier A total of 114 professionals completed the Copenhagen Burnout Inventory and a demographic questionnaire. No statistically differences in burnout in professionals working in closed and open wards were found. However, we found professionals to score highest on personal and work-related burnout and lowest on client-related burnout. This indicates that patients may only play a minor role in burnout in health professionals.The underwater phase is perhaps the most important phase of the swimming start. To improve performance during the underwater phase, it is necessary to improve our understanding of the key variables affecting this phase. The main aim of this study was to identify key kinematic variables that are associated with the performance of an underwater glide of a swimming start, when performed at streamlined position without underwater undulatory swimming. Sixteen experienced swimmers performed 48 track starts and 20 kinematic variables were analysed. A multiple linear regression analysis was carried out to explore the relationship between glide performance (defined as glide distance) and the variables that may affect glide performance. Four variables in the regression model were identified as good predictors of glide distance flight distance; average velocity between 5 m and 10 m; and maximum depth of the hip. The results of the present study help improve our understanding of underwater glide optimisation and could potentially facilitate improvement of overall start performance.

As part of the special issue on 'Women in Science', this review offers a perspective on past and ongoing work in the field of normal (non-cancer) tissue radiation biology, highlighting the work of many of the leading contributors to this field of research. We discuss some of the hypotheses that have guided investigations, with a focus on some of the critical organs considered dose-limiting with respect to radiation therapy, and speculate on where the field needs to go in the future.

The scope of work that makes up normal tissue radiation biology has and continues to play a pivotal role in the radiation sciences, ensuring the most effective application of radiation in imaging and therapy, as well as contributing to radiation protection efforts. However, despite the proven historical value of preclinical findings, recent decades have seen clinical practice move ahead with altered fractionation scheduling based on empirical observations, with little to no (or even negative) supporting scientific data. Given ocal and systemic intervention. From our personal perspective as five 'Women in Science', we would like to acknowledge and applaud the role that many female scientists have played in this field. We stand on the shoulders of those who have gone before, some of whom are fellow contributors to this special issue.

The purpose of the study was to show the outstanding contribution of Elena Alexandrovna Timofeeva-Resovskaya (1898-1973) to the development of radiobiology.

We reviewed the author's memoirs and materials from the personal archive, as well as literary and electronic sources.

For the first time the autobiography of Elena A. Timofeeva-Resovskaya and the periods of her scientific activity were revealed. We demonstrated the primary role of Elena A. Timofeeva-Resovskaya in the research of aquatic ecosystems. The results of her research turned out to be important both for solving the problems of radioactive contamination of territories and for the development of modern radioecology. Throughout her life, she worked with her husband Nikolay V. Timofeev-Resovsky (1900-1981), a great scientist and prominent scientific enlightener. There was no purpose to describe the life of Timofeev-Resovskies family, full of exciting events, but it was not possible to avoid it. For young women in science, Elena A. Timofeeva-Resovskaya can provide an example of a successful scientific career even in turbulent times.

For the first time the autobiography of Elena A. Timofeeva-Resovskaya and the periods of her scientific activity were revealed. We demonstrated the primary role of Elena A. Timofeeva-Resovskaya in the research of aquatic ecosystems. The results of her research turned out to be important both for solving the problems of radioactive contamination of territories and for the development of modern radioecology. Throughout her life, she worked with her husband Nikolay V. Timofeev-Resovsky (1900-1981), a great scientist and prominent scientific enlightener. There was no purpose to describe the life of Timofeev-Resovskies family, full of exciting events, but it was not possible to avoid it. For young women in science, Elena A. Timofeeva-Resovskaya can provide an example of a successful scientific career even in turbulent times.

Educational coproduction, in which learners partner with educators to create and improve their educational experiences, can facilitate student-centered medical education. Empirical descriptions of best practices for involving students in clinical curricular coproduction are needed. We aimed to understand faculty and student perspectives on methods, perceived benefits, and common barriers and solutions to clinical curricular coproduction.

We conducted an international mixed-methods study of clinical curricular coproduction in undergraduate medical education and longitudinal integrated clerkships specifically. Faculty and students identified through an international listserv received an electronic survey to identify methods, benefits, and challenges of clinical curricular coproduction. We conducted semi-structured interviews with a subset of survey participants. We present descriptive statistics for survey data and themes derived from inductive qualitative analysis.

Two hundred forty-seven individuals (10ners in clinical curricular coproduction.

This extraordinary woman worked her professional way from a radiation protection engineer to become the successful principal investigator of a prestigious international European project for a new radiation therapy (ERC Synergy grant, HORIZON 2020). The evaluation of the submitted proposal was very positive. The panel proposed that it be funded. Elke tragically passed away a few days before this conclusion of the panel. The present account describes her gradual career development; it includes many episodes that Elke personally chronicled in her curriculum of 2017.

An internet literature search was performed using Google Scholar and other sources to assist in the writing of this narrative review and account.

In parallel to the development of the new Biomedical Beamline ID17 at the European Synchrotron Radiation Facility in Grenoble in the late nineties, Elke focused her interest and her personal and professional priorities on MRT, particularly on its clinical goals. She outlined her main objectives in sev at the ESRF that required development of new, specific state of the art modalities and tools for treatment planning, dosimetry, dose calculation, patient positioning and, of particular importance, redundant levels of patient safety. Just as she was about to take responsibility as principal investigator for a prestigious international European project on a new radiation therapy, death called Elke in.Background and objectives Influenza vaccination rates among medical students (MSs) are below the standards recommended in hospitals where influenza vaccination is not mandatory. We carried out a comparative study in two Spanish university hospitals to reassert this fact and evaluated the impact on vaccination rates of a specific program aimed at promoting influenza vaccination among MSs.Methods A descriptive cross-sectional study was performed describing influenza vaccination rates and motivations for vaccination during the 2017/18 campaign among MSs in two hospitals affiliated to the same university. We subsequently performed a community-based intervention study during the 2018/19 campaign evaluating the impact of a strategy for promoting influenza vaccination, comparing the hospital where the intervention took place (hospital A) with the one where it did not take place (hospital B).Results During de 2017/18 campaign the overall influenza vaccination rate was 44.8%, with no differences between hospitals A and B (difference 3.9%; 95% CI -4.36-12.16; p-value = .4). During the 2018/19 campaign, vaccination rate increased to 76.4% in hospital A, with significant differences compared with the previous campaign in the same hospital (29.8%; OR 5.00; 95% CI 3.14-8.3; p-value = .0001) and with that observed in hospital B in the same campaign (21.1%; 95% CI 13.38-28.82; p-value less then .001).Conclusions Influenza vaccination rates among MSs in two Spanish university affiliated hospitals were below the recommended standards. A new reproducible strategy for promoting influenza vaccination with a specific approach toward MSs achieved a significant improvement in vaccination rate.Hg2+ toxicity is one of the most common chemical poisonings that occurs mainly from drinking polluted water. In the current work, Phycocyanin (PC) was exploited as a fluorescent sensor for sensitive and selective detection of Hg2+ in an aqueous system. PC-Hg2+ interaction was monitored using a spectro-fluorometer under different buffered solutions at pH values of 6,7,8,9, or 10 above the isoelectric point of PC (5.18). A remarkable decrease of PC fluorescence intensity was observed under Tris-buffer at pH 6 upon the addition of increasing Hg2+ concentrations (1-120 nM). Under the maintained experimental conditions, the current sensor showed a good linear relationship with R2 = 0.9971 and a limit of detection as low as 0.7 nM was achieved. In addition, a notable selectivity of Hg2+ over other nine heavy metals (Cu2+, Zn2+, Pb2+, Mg2+, Mn4+, Li+, Fe3+, Co2+, and Al3+) was achieved in the presence of 120 nM of each metal. Moreover, the current fluorescent detection assay was also tested in real samples of pond water, and recoveries as well as relative standard deviations within the acceptable limits were recorded.