Munchbanke3139

Spirostanol glycoside 7 exhibited cytotoxicity toward the SBC-3 cells (IC50 1.3 μM). Additionally, 7 at 0.1 and 1.0 µM synergistically enhanced the cytotoxicity of etoposide against SBC-3 cells; compound 7 induced the release of DAMPs; the release of HMGB1, the secretion of ATP, and the exposure of CALR in the SBC-3 cells. Furthermore, the combination of 7 and etoposide resulted in increasing the extracellular release of DAMPs. These data indicated that 7, as well as its combination with etoposide, might potentially cause immunogenic cell death.

Contrary to evidence from the Western literature, cases of filicide in Ghana are mostly unreported because they are rooted in cultural practices and hidden from the general public.

The purpose of this study was to explore the cultural context of filicide in a rural community. Particularly, to provide an understanding of the spirit child (SC) phenomenon, how the killing of a SC is performed and to provide a general understanding of filicide within a particular context.

Four relatives of a family that engaged in a filicide incident took part in the study. The interviews were conducted in a rural community in Ghana where the incident occurred.

Short written narratives were used to explore the experiences and perceptions of relatives whose family engaged in filicide.

Children with severe deformities are likely to be associated with matters of divinity which gives way for the conceptualization of the SC and its attendant filicide. The findings highlight the critical role of traditional healers in rural communities and the consequences of strong community beliefs and expectations that influence parents to commit filicide.

The study provides directions for child protection workers to address the stigma parents face for having children with severe deformities and to provide education on child welfare legislation.

The study provides directions for child protection workers to address the stigma parents face for having children with severe deformities and to provide education on child welfare legislation.

Pushing out (off-rolling) occurs where pupils are illegally excluded from school. Those receiving children's social care (CSC) services (children in need (CiN), on child protection plans (CPPs) or looked after (CLA)) are thought to be at increased risk, but limited evidence inhibits understanding of this phenomenon. The extent of pushing out can be inferred from non-enrolment in administrative data.

To estimate proportions of children not enrolled across secondary school (aged 11-16, up to year 11) and to explore the association between CSC history and non-enrolment in year 10/11.

>1M pupils in year 7 (aged 11/12) in English state schools, 2011/12 and 2012/13.

We estimated the proportion of children not enrolled across years 8 to 11, disaggregated by CSC history. We assessed with regression modelling the association between CSC history and non-enrolment in years 10/11.

Of children without CSC history, 3.8% had ≥1year not enrolled by year 11. This was higher in those with a history CiN (8.1%), CPP (9.4%) or CLA (10.4%) status. The odds of non-enrolment in years 10/11 were higher among those with CLA history vs non-exposed peers (OR 4.76, 95% CI 4.49-5.05) as well as in those with CPP history (3.60, 3.39-3.81) and CiN history (2.53, 2.49-2.58). History of special educational needs further increased non-enrolment odds, including after confounder adjustment.

Findings imply that children with CSC history are more likely to be pushed out from school than children without, especially those with special educational needs.

Findings imply that children with CSC history are more likely to be pushed out from school than children without, especially those with special educational needs.The search for improvements in the poultry production chain and for increased egg productivity have grown significantly. However, intensive production with or by using of confinement systems negatively affect the welfare of animals and is favoring the appearance of harmful ectoparasites in production. Due to differences in the existing management systems, (e.g. Californian and cage-free systems) and given the importance of the poultry industry in the international market, the aim of the present study was (1) to compare mite community between SIG (Intensive system - cage Californian) and SIF (Intensive system - free cage free); (2) egg-laying systems to analyze how the abundances of the ectoparasites Dermanyssus gallinae, Megninia ginlgymura, and Ornithonyssus sylviarum are affected by these egg-laying models; (3) to evaluate the association between the functional diversity found in traps, organic matter, and feathers in both systems; and finally, (4) to analyze how abiotic factors (e.g. humidity, temperature iarum populations. Organic matter had a high abundance of predatory mites with potential for controlling mites of sanitary importance in the poultry chain.Perfluoroalkyl substances (PFASs) are known to be persistent and toxic, and can be accumulated and trophic magnified in the environments. PFASs are widely distributed, and their coastal input poses a threat to the health of aquatic organisms and local residents. In present study, 17 PFASs including one emerging polyether substitute in water, sediment, and organisms were investigated from the South China Sea. Perfluorobutanoic acid (PFBA) was predominant in water, of which concentration ranged from ND to 10.26 ng/L, with a mean of 5.21 ng/L. Similar to sediment and organisms, PFBA was the substance with the highest concentration detected among PFASs. This result seemingly indicated that use of short-chain PFASs as substitutes for long-chain PFASs in recent years. Trophic magnification factors (TMFs) of PFASs were estimated in the marine food web. TMFs > 1 was observed only in perfluorooctane sulfonic acid (PFOS), indicating a biomagnification potential of PFOS in the given ecosystem. The estimated daily intake (EDI) of PFOS and PFOA were most prevalent in mollusk, whereas the EDI of PFBA was greater in fish and shrimp. The hazard ratio (HR) reported for seven dominant PFASs were lower than 1, which suggests that PFASs via seafood consumption would not cause significant health risk to local residents.In this work, zero-valent Fe-Cu bimetallic nanoparticles were synthesized using a facile method, and applied to activate sulfite for the degradation of sulfamethazine (SMT) from the aqueous solution. The key factors influencing SMT degradation were investigated, namely the theoretical loading of Cu, Fe-Cu catalyst dosage, sulfite concentration and initial solution pH. The experimental results showed that the Fe-Cu/sulfite system exhibited a much better performance in SMT degradation than the bare Fe0/sulfite system. The mechanism and possible degradation pathway of SMT in Fe-Cu/sulfite system were revealed. The reactive radicals that played a dominant role in the SMT degradation process were •OH and SO4•-, while the loading of Cu induced the synergistic effect between Fe and Cu. The redox cycle between Cu(I)/Cu(II) remarkably contributed to the conversion of Fe(III) to Fe(II), greatly enhancing the catalytic performance of Fe-Cu bimetal. In real groundwater applications, the Fe-Cu/sulfite system also exhibited satisfactory SMT degradation. The 30-day aging tests of Fe-Cu particles demonstrated that the aging of catalyst was not obviously affecting the removal of SMT. Furthermore, the reusability of catalyst was evidenced by the recycling experiments. This study provides a promising application of bimetal activated sulfite for enhanced contaminant degradation in groundwater.Interactions of surface water and groundwater (SW-GW) in hyporheic zones produce biogeochemical hotspots. However, response patterns of hyporheic groundwater to external influences remain unclear. In this study, three datasets (hydrochemistry, antibiotics, and microbiome) were collected over a hydrological year to explore the influence of a 12-year managed aquifer recharge (MAR) project. We observed that the long-term MAR practice elevated nutrient and antibiotic levels while reduced redox potential in hyporheic groundwater, and these impacts depended on decreasing SW-GW interaction intensity with aquifer depth. In contrast, the long-term MAR practice increased community dissimilarity of 30-m groundwater but had little impact on 50-m or 80-m groundwater. Moreover, hyporheic community assembly was dominated by dispersal limitation, and thereby co-varied hydrochemistry and antibiotics only attributed to small community variability. selleck chemicals llc The long-term MAR practice decreased species-interaction intensity and changed the abundance of metabolic functions in hyporheic groundwater. Furthermore, predicted community functions involving carbon, nitrogen, sulfur, and manganese cycles for 30-m groundwater showed higher abundances than those for 50- and 80-m groundwater. Collectively, we showed that hyporheic groundwater was sensitive to the SW-GW interaction and human activities, with the interactions of hydrochemistry, contaminants, and microbiome linking to hyporheic groundwater quality and ecosystem functioning.Appropriate characterization of site soils is essential for accurate risk assessment of soil vapor intrusion (VI). In this study, we develop a data assimilation method based on deep learning (i.e., ES(DL)) to estimate the distribution of soil properties with limited measurements. Two hypothetical VI scenarios are employed to demonstrate site characterization using the ES(DL) method, followed by validation with a laboratory sandbox experiment and then one practical site application. The results show that the ES(DL) method can provide reasonable estimates of the effective diffusion coefficient distributions and corresponding emission rates (into the building) in all four cases. The spatial heterogeneity of site soils can be characterized by considerably enough measurements (i.e., 15 sampling points in the first hypothetical case); otherwise, layered characterization is recommended at the cost of neglecting horizontal heterogeneity of site soils. This new method provides an alternative to characterize VI sites with relatively fewer sampling efforts.This study aimed at optimizing the one-step chemical activation and microwave pyrolysis of an agro-industrial waste to obtain a microporous activated carbon (AC) with superior textural and adsorptive properties by a fast, low-reagent and low-energy process. Spent brewery grains were used as precursor, and the antibiotics sulfamethoxazole (SMX), trimethoprim (TMP) and ciprofloxacin (CIP) were considered as target adsorbates. A fractional factorial design was applied to evaluate the effect of the main factors affecting the preparation of AC (activating agent, activating agentprecursor ratio, pyrolysis temperature and residence time) on relevant responses. Under optimized conditions (K2CO3 activation, pyrolysis at 800 °C during 20 min and a K2CO3precursor ratio of 12), a microporous AC with specific surface area of 1405 m2 g-1 and large adsorption of target antibiotics (82-94%) was obtained and selected for further studies. Equilibrium times up to 60 min and maximum Langmuir adsorption capacities of 859 µmol g-1 (SMX), 790 µmol g-1 (TMP) and 621 µmol g-1 (CIP) were obtained.