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We show that this methodology was beneficial for acquiring fungal treasures for drug discovery. These studies also enabled the investigation of the molecular function of natural products in fungal development.

Healthcare workers are ahigh-risk population for SARS-CoV‑2 infection. For capacity planning of healthcare providers and to optimize protection of healthcare workers (HCW) in SARS-CoV‑2 pandemics, it is essential to know the risk of infection and potential immunity status of staff dealing with COVID-19 patients.

We examined seropravalence of SARS-CoV‑2 IgM/IgG antibodies (AB) in HCW of aregion with the highest rate of infection (1570/100,000) during COVID-19 pandemic in Germany, 4months after its start. Employees of anonmedical company (MU) served as control group. Demographic data, medical history and working situation were recorded.

Atotal of 1838 HCW and 986 MU volunteered to participate. Seroprevalence for SARS-CoV‑2 in HCW was 15.1% and 3.7% in MU. Among HCWs, nurses had aseropositivity of 20.0%, ICU personnel 20.3%, housekeepers 19.3%, physicians 12.0%, medical services (e.g., radiology, physiotherapy) 11.3%, administration 7.1% and technical services 6%. Symptoms typical for COVID-19 were not experienced by 10% of seropositive HCWs.

Seroprevalence of SARS-CoV‑2 antibodies in HCW of aregion heavily affected by COVID-19 is with 15.1% significantly higher than in acontrol group of nonmedical staff with 3.7%. Infection rate in HCW was higher in staff with close contact to infected patients. Seropositivity in ICU personnel is higher than in other clinical professions. The occupational risk for housekeepers seems to be underestimated.

Seroprevalence of SARS-CoV‑2 antibodies in HCW of a region heavily affected by COVID-19 is with 15.1% significantly higher than in a control group of nonmedical staff with 3.7%. Infection rate in HCW was higher in staff with close contact to infected patients. Seropositivity in ICU personnel is higher than in other clinical professions. The occupational risk for housekeepers seems to be underestimated.

To investigate how scaling affects the penetration of microorganisms into dentinal tubules, how pulpal cells seeded into the pulp cavity respond to bacterial challenge, and how penetration and inflammatory response may depend on the bacterial composition.

Root canals of 102 extracted human teeth underwent shaping and cleaning. Half of the teeth were subjected to scaling and root planing, the other half remained untreated. Teeth were exposed to either Streptococcus gordonii and Actinomyces oris or S. gordonii and Porphyromonas gingivalis for 10 weeks. Bacterial invasion was assessed in a depth of 1 mm to the root surface. Human pulpal cells were seeded into the cavities to assess the expression of interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and matrix metalloproteinase-3 (MMP-3) by real-time polymerase chain reaction and immunoassay.

The percentage of teeth with bacteria detected in dentine was higher when teeth received scaling than when they were untreated 66.6% versus 44.4% when exposed to A. oris/S. gordonii, and 50% versus 25% when exposed to P. gingivalis/S. gordonii (p = 0.043). Scaling had no impact on IL-8 and MMP-3 expression in pulpal cells. P. gingivalis/S. gordonii caused higher levels of IL-8, MCP-1, and MMP-3 than A. oris/S. gordonii (p = 0.003, p = 0.011, p = 0.037).

Scaling supports the penetration of bacteria into the dentine of extracted human teeth. P. gingivalis may affect the immune response in pulpal cells.

Root surface debridement with hand instruments may facilitate bacterial penetration. Protein Tyrosine Kinase inhibitor Other kinds of mechanical instrumentation in this experimental setting should be investigated.

Root surface debridement with hand instruments may facilitate bacterial penetration. Other kinds of mechanical instrumentation in this experimental setting should be investigated.Time perspective refers to humans' concept of integrating and evaluating temporal position and evaluation of memories, emotions, and experiences. We tested the hypothesis that different aspects of time perspective, as assessed with the Zimbardo Time Perspective Inventory (ZTPI) are related to variation of brain structure in non-clinical subjects. Analysing data from n = 177 psychiatrically healthy subjects using voxel-based morphometry with the CAT12 software package, we identified several significant (p  less then  0.05 FWE, cluster-level corrected) associations. The factors past negative, reflecting a negative attitude towards past events and present fatalistic, measuring a hopeless and fatalistic attitude towards future life, were both negatively associated with grey matter volumes of the anterior insula. The ZTPI factor future was negatively associated with precuneus grey matter. There was no association of ZTPI scores with gyrification using an absolute mean curvature method, a marker of early brain development. These findings provide a link between a general psychological construct of time perspective and brain structural variations in key areas related to time keeping (anterior insula) and the default mode network (precuneus), both of which overlap with variation in behavioral aspects and psychopathology.Owing to the large inter-subject variability, early post-stroke prognosis is challenging, and objective biomarkers that can provide further prognostic information are still needed. The relation between quantitative EEG parameters in pre-thrombolysis hyper-acute phase and outcomes has still to be investigated. Hence, possible correlations between early EEG biomarkers, measured on bedside wireless EEG, and short-term/long-term functional and morphological outcomes were investigated in thrombolysis-treated strokes. EEG with a wireless device was performed in 20 patients with hyper-acute ( less then  4.5 h from onset) anterior ischemic stroke before reperfusion treatment. The correlations between outcome parameters (i.e., 7-day/12-month National Institutes of Health Stroke Scale NIHSS, 12-month modified Rankin Scale mRS, final infarct volume) and the pre-treatment EEG parameters were studied. Relative delta power and alpha power, delta/alpha (DAR), and (delta+theta)/(alpha+beta) (DTABR) ratios significantly correlated with NIHSS 7-day (rho = 0.