Muirbrask9999

Please see http//www.annualreviews.org/page/journal/pubdates for revised estimates.INTRODUCTION Children requiring speech pathology services in rural and remote locations face many barriers in accessing adequate services. This has particular consequences for children who need intensive treatment for therapy to be effective, such those with childhood apraxia of speech (CAS). Parent training has been used to overcome speech pathology service delivery barriers for a range of other communication disorders. However, the effectiveness of training parents to deliver a motor-based treatment for CAS within rural and remote contexts has not been evaluated. This study examined the effectiveness and feasibility of training parents in a rural community to use the treatment approach of dynamic temporal and tactile cueing (DTTC) in order to provide more intensive treatment sessions at home. METHODS The study used an experimental single case across behaviours design and parent interviews to evaluate outcomes both quantitatively and qualitatively. The study included four parent-child dyads from a mixed socioeconomic rural community in Canada. Child participants ranged in age from 3 years to 8 years. Child treatment outcomes were measured using an improvement rate difference (IRD) calculation based on percentage of phonemes correct. Fidelity to the treatment protocol was measured using a fidelity score. RESULTS All parents reported challenges in carrying out the program due to social and behavioural challenges. Parents also reported benefits such as being able to spend more time with their child and learning some useful cueing techniques. Only one of the four participants had a moderate effect size for his target words (IRD=57%). CONCLUSION While training parents to deliver DTTC may be effective for some parent-child dyads, clinicians are advised that parent training may not be suitable for all families, and parents in rural and remote communities may face particular social circumstances that make following through with an intensive treatment program difficult.Two azo functionalized Zn(II)-based MOFs, [Zn(SDB)(3,3'-L)0.5]·xGn, IITKGP-13A, and [Zn2(SDB)2(4,4'-L)]·xGn, IITKGP-13B (IITKGP stands for Indian Institute of Technology Kharagpur), have been constructed through the self-assembly of isomeric N,N'-donor spacers (3,3'-L = 3,3'-azobispyridine and 4,4'-L = 4,4'-azobispyridine) with organic ligand 4,4'-sulfonyldibenzoic acid (SDBH2) and Zn(NO3)2·6H2O (G represents disordered solvent molecules). Single-crystal X-ray diffraction studies reveal the 2D structure with sql topology for both MOFs. However, the subtle change in positions of coordinating N atoms of spacers makes IITKGP-13A noninterpenetrated, while IITKGP-13B bears a 2-fold interpenetrated structure. IITKGP-13A exhibits higher uptake of CO2 over CH4 and N2 with high IAST selectivities for mixed CO2/CH4 (5050, biogas) and CO2/N2 (1585, flue gas) gas systems. In contrast, IITKGP-13B takes up very low amount of CO2 gas (0.4 mmol g-1) compared to IITKGP-13A (1.65 mmol g-1) at 295 K. Density functional theory (DFT)-based electronic structure calculations have been performed to explain the origin of the large differences in CO2 uptake capacity between the two MOFs at the atomistic level. The results show that the value of the change in enthalpy (ΔH) at 298 K temperature and 1 bar pressure for the CO2 adsorption is more negative in IITKGP-13A as compared to that in IITKGP-13B, thus indicating that CO2 molecules are more favored to get adsorbed in IITKGP-13A than in IITKGP-13B. The computed values for the Gibbs' free energy change (ΔG) for the CO2 adsorption are positive for both of the MOFs, but a higher value is observed for the IITKGP-13B. The noncovalent types of interactions are the main contribution toward the attractive energies between the host MOF frameworks and guest CO2 molecules, which has been studied with the help of energy decomposition analysis (EDA).Glioblastoma multiforme (GBM) is one of the most aggressive tumors with median survival of only 15 months. Effective therapeutics need to overcome the formidable challenge of crossing the blood brain barrier (BBB). Receptors and transporters overexpressed on BCECs are being used for designing liposomes, polymers, polymeric micelles, peptides and dendrimer-based drug carriers for combating brain tumors. Herein, using orthotopic mouse glioblastoma model, we show that co-delivering small molecule inhibitor of JAK/STAT pathway (WP1066) and STAT3siRNA with nanometric (100-150 nm) α5β1 integrin receptor selective liposomes of RGDK-lipopeptide hold therapeutic promise in combating glioblastoma. The selective accumulation of intravenously administered near infrared (NIR)-dye labeled α5β1 integrin receptor selective liposomes of RGDK-lipopeptide in the mouse brain tumor tissue. Importantly, we show that i.v. injection of WP1066 (a commercially sold small molecule inhibitor of JAK/STAT pathway) & STAT3siRNA co-solubilized within the liposomes of RGDK-lipopeptide leads to significant inhibition (>350% compared to the untreated mice group) of orthotopically growing mouse glioblastoma. check details The present strategy may find future use in combating GBM.Organic radical monolayers (r-MLs) bonded to metal surfaces are potential materials for the development of molecular (spin)electronics. Typically, stable radicals bearing surface anchoring groups are used to generate r-MLs. Following a recent theoretical proposal based on a model system, we report the first experimental realization of a metal surface-induced r-ML, where a rationally chosen closed-shell precursor 3,5-dichloro-4-[bis(2,4,6-trichlorophenyl)methylen]cyclohexa-2,5-dien-1-one (1) transforms into a stable neutral open-shell species (1•) via chemisorption on the Ag(111) surface. X-ray photoelectron spectroscopy reveals that the >C═O group of 1 reacts with the surface, forming a C-O-Ag linkage that induces an electronic rearrangement that transforms 1 to 1•. We further show that surface reactivity is an important factor in this process whereby Au(111) is inert towards 1, whereas the Cu(111) surface leads to dehalogenation reactions. The radical nature of the Ag(111)-bound monolayer was further confirmed by angle-resolved photoelectron spectroscopy and electronic structure calculations, which provide evidence of the emergence of the singly occupied molecular orbital (SOMO) of 1•.