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03, 95% C.I. 0.79 to 1.35), nor increased bleeding (5840/10906 patients, OR 0.84, 95% C.I. 0.65 to 1.08), but it was associated with higher anti-Xa levels (284/294 patients, ES 2.04, 95% C.I. 1.16 to 2.92, p<0.0001). A significant heterogeneity was present for comparison of anti-Xa levels (I

=94%, p=0.0001) but not for VTE occurrence or bleeding (I

=7.6% and 12.8% respectivel). None of the moderators explained the heterogeneity of the results among primary studies.

Weight-adjusted dose as compared to fixed-dose of heparins in the prevention of VTE in obese patients was not associated with a lower risk of VTE nor a higher risk of bleeding.

Weight-adjusted dose as compared to fixed-dose of heparins in the prevention of VTE in obese patients was not associated with a lower risk of VTE nor a higher risk of bleeding.

Adrenomedullin (AM) is a vasoactive peptide mostly secreted by endothelial cells with an important role in preserving endothelial integrity. The relationship between AM and hereditary hemorrhagic telangiectasia (HHT) is unknown. We aimed to compare the serum levels and tissue expression of AM between HHT patients and controls.

Serum AM levels were measured by radioimmunoassay and compared between control and HHT groups. https://www.selleckchem.com/products/TG100-115.html AM levels were also compared among HHT subgroups according to clinical characteristics. The single nucleotide polymorphism (SNP) rs4910118 was assessed by restriction analysis and sequencing. AM immunohistochemistry was performed on biopsies of cutaneous telangiectasia from eight HHT patients and on the healthy skin from five patients in the control group.

Forty-five HHT patients and 50 healthy controls were included, mean age (SD) was 50.7 (14.9) years and 46.4 (9.9) years (p=0.102), respectively. HHT patients were mostly female (60% vs 38%, p=0.032). Median [Q1-Q3] serum AM levels were 68.3 [58.1-80.6] pg/mL in the HHT group and 47.7 [43.2-53.8] pg/mL in controls (p<0.001), with an optimal AM cut-off according to Youden's J statistic of 55.32 pg/mL (J0.729). Serum AM levels were similar in the HHT subgroups. No patient with HHT had the SNP rs4910118. AM immunoreactivity was found with high intensity in the abnormal blood vessels of HHT biopsies.

We detected higher AM serum levels and tissue expression in patients with HHT than in healthy controls. The role of AM in HHT, and whether AM may constitute a novel biomarker and therapeutic target, needs further investigation.

We detected higher AM serum levels and tissue expression in patients with HHT than in healthy controls. The role of AM in HHT, and whether AM may constitute a novel biomarker and therapeutic target, needs further investigation.

This study adapted the Sense of Coherence (SOC) Scale for Korean adolescents with chronic diseases and evaluated its psychometric properties.

This study aimed to validate the Sense of Coherence Scale for Korean adolescents with Chronic Disease (SOC-AC).

This study employed the cross-sectional design. In total, 144 adolescents with chronic diseases (age 15.07 ± 1.62 years; 58% male) responded to the study questionnaire, which included the 13-item SOC scale (SOC-13) and the 10-item Children's Depression Inventory. The SOC-13 was shortened to create the 10-item SOC-AC. Through an exploratory factor analysis (EFA) and a confirmatory factor analysis (CFA).

Following the EFA, two items (Item 8 and 13) with low factor loadings were deleted. Further, following the CFA, one item (Item 2) with a high modification index was deleted. The resulting 10-item SOC-AC exhibited a 3-factor structure comprising the subscales of meaningfulness (Item 4, 7, and 12), comprehensibility-manageability (Item 3, 5, 9, and 11), and resilience (Item 1, 6, and 10). The internal consistency of the SOC-AC was 0.868; the Cronbach's alpha values were 0.765, 0.78, and 0.529 for the meaningfulness, comprehensibility-manageability, and resilience subscales. The Pearson's correlation coefficient for the association between the SOC-13 and depression showed acceptable criterion-related validity (r = -0.436, p < .0001).

These findings indicate that the SOC-AC has satisfactory psychometric properties and that it is useful for assessing SOC in adolescents with chronic diseases.

This study revealed the utility of the examined scale to measure SOC as a means of health promotion and care in adolescents with chronic diseases.

This study revealed the utility of the examined scale to measure SOC as a means of health promotion and care in adolescents with chronic diseases.

To assess the contribution of large and small nerve fiber alteration in erythromelalgia (EM).

Thirty-three EM patients were included and underwent clinical evaluation based on EM severity score, DN4, and Utah Early Neuropathy Scale (UENS) score. Neurophysiological evaluation consisted in nerve conduction studies (NCS) for large nerve fibers and specific tests for small nerve fibers electrochemical skin conductance, cold and warm detection thresholds, and laser evoked potentials. Finally, the evaluation of vascular changes was based on the presence of clinical feature of microvascular disorders and the measurement of the Toe Pressure Index (TPI).

While 28 patients (85%) had vascular alteration on TPI or clinical features, 23 patients (70%) had small-fiber neuropathy on neurophysiological tests, and only 10 patients (30%) had large fiber neuropathy on NCS. Regarding clinical scores, there was no difference between groups (presence or absence of large- or small-fiber neuropathy or microvascular disorder) except for a higher UENS score in patients with large fiber neuropathy.

Peripheral neuropathy, mostly involving small nerve fibers, is almost as common as microvascular changes in EM, but remains inconstant and not related to a specific neuropathic pattern or higher clinical severity.

The association of neuropathic and vascular factors is not systematic in EM, this syndrome being characterized by different pathophysiological mechanisms leading to a common clinical phenotype.

The association of neuropathic and vascular factors is not systematic in EM, this syndrome being characterized by different pathophysiological mechanisms leading to a common clinical phenotype.