Morrisonboll5084

65 of them are identified as newly discovered natural products. All the compounds discussed herein, have exhibited promising efficacy against various bacterial strains.Current research on prothioconazole (PTC), a broad-spectrum triazole fungicide, mainly focuses on its efficacy and residues; only a few studies have been assessing its toxicological effects. Using acute and chronic toxicity tests, we assessed the effects of PTC and its metabolite prothioconazole-desthio (PTCd) on the inhibition of the activity, growth, and reproduction of Daphnia magna. A dose-response relationship was established to determine sensitive biological indicators. In the acute and chronic toxicity tests, the 48-h EC50 (concentration for 50% of the maximal effect) of PTC and PTCd for D. magna were 2.82 and 5.19 mg/L and 0.0807 and 0.132 mg/L, respectively; in the latter test, PTC was 1.64 times more toxic than PTCd. Acute-to-chronic toxicity ratios were calculated using chronic toxicity data; the ratios were 227 and 27.5 for PTC and PTCd, respectively. Our results indicate that both PTC and PTCd affect the growth and reproduction of D. magna and that the toxicity of PTC is greater than that of PTCd. In conclusion, the metabolites of PTD are toxic to D. magna at certain concentrations, and their environmental risks should not be neglected.Sulfadiazine (SDZ) is a typical persistent sulfonamide antibiotic, which has been widely detected in natural drinking water sources. The degradation of SDZ by UV/Oxone (potassium monopersulfate compound) was explored in this study. The results showed that Cl- can effectively activate PMS to promote rapid degradation of SDZ in the Oxone process by forming chlorine in the system. Radical quenching tests suggested that radical oxidation, including HO•, SO4•-, and reactive chlorine species (RCS), played an important role by UV/Oxone. It further verified that concentration and distribution of HO•, SO4•-, and RCS were pH-dependent; RCS act as a major contributor at pH 6.0 and pH 7.0 to degrade SDZ in this process. The SDZ degradation rate was firstly increased and then decreased by Cl- and HCO3- (0-10 mM); HA (0-10 mg L-1) exhibited insignificant influence on SDZ degradation. The degradation pathways of SDZ during UV/Oxone and formation pathways of five disinfection byproducts during subsequent chlorination were proposed. The possible DBP precursors formed by SO2 extrusion, hydroxylation, and chlorination of SDZ during UV/Oxone pre-oxidation.As common meteorological factors in daily life, there is limited evidence for the effect of ambient temperature and humidity during pregnancy on the risk of term low birth weight. Furthermore, little is known about the interaction of ambient temperature and humidity on TLBW. The objective of the study was to explore the effect of ambient temperature, humidity during pregnancy, and their interaction on the risk of TLBW and, moreover, to identify exposure critical window. We recruited 6640 infants and their mothers to build a birth cohort study in Jinan City, China, from January 2018 to December 2019. The associations between temperature and humidity during pregnancy and TLBW were estimated by generalized additive model, logistic regression model, and interaction analysis, and the critical window was identified by the distributed lag non-linear model. The incidence of TLBW was 1.36% for the infants in the birth cohort. TLBW was related to the low level of temperature and humidity in the whole pregnancy, compared with the moderate level and the adjusted ORs were 4.44 (1.65-11.42) and 6.23 (1.92-21.39), respectively. The indicators of the interaction analysis of temperature and humidity were not statistically significant. For the low level of humidity, the association with TLBW was statistically significant at first to sixth gestational weeks, and the maximum OR in male infants (3.95, 1.70-9.16) was higher than that in females (1.96, 1.06-3.63). For the low level of temperature, we failed to find significant association with TLBW at each gestational week. The low level of temperature and humidity during pregnancy could increase the risk of TLBW. There was no statistical interaction between temperature and humidity on TLBW. Moreover, the early stage of pregnancy was the critical window for humidity exposure, in which the boys had a greater effect.The global trends of sustainable agriculture (SA) have expanded dramatically through many scholarly studies in this area. Many literary works have focused on several aspects of sustainable agriculture (SA), such as the effectiveness of pesticide management, impacts on cultivation and enhancement, quantifying with soil, water, and air, agro-ecological activities, ecological aspects, and other areas of focus. The review offers a structured bibliometric and network evaluation that will profoundly observe the recent trends of SA, which other studies in this field have not comprehensively analyzed before. The study's prime objectives are to investigate the progress, trends and themes, and provide a comprehensive mapping of the field of sustainable agriculture. The study utilizes the Web of Science core collection database to search, filter, and extract the published article from 1992-2020. The review commences by exploring over 3000 journal articles, those then filtered into some well-recognized matrix of impacts and published by impactful journals, institutions, and authors. The results indicate a stable growth in publications since 2006, with a sharp improvement from 2010. Thematic assessment of key concepts by exploring the abstract discovered a robust emphasis on quantitative resource associations within a strong subjective focus with farm capacities and inner-sectorial dominations. We reveal how the outcome may assist the sectors to facilitate better understandings and comprehend the challenging transitions based on brainstorming to action formulation.Recent evidences illustrated that the release of aluminum oxide nanoparticles (Al2O3-NPs) into the biosphere may pose risk to the environment and cause adverse effects on living organisms including humans. The current study assessed the hepatotoxic effects of Al2O3-NPs on developing chicken embryo and cell culture models. Results demonstrated that Al2O3-NPs exposure causes histological abnormalities and increased the level of tissue damage markers (ALP, AST, and ALT) in the embryonic liver. Furthermore, increased oxidative stress (TBARS) and impaired function of antioxidant enzymes (SOD, CAT, and GPx) were also observed. Moreover, it adversely affects red blood cells (RBC) morphology, liver metabolism, and stress response gene expression (HO-1 and NQO-1). Dose-dependent ROS generation and cytotoxic response in addition to potentiating effect on tumor necrosis factor alpha (TNF-α)-induced apoptosis (caspase-3 activity) were also observed. Inhibition of p38 mitogen-activated protein kinase (p38 MAPK) and c-Jun N-terminal kinase (JNK) pathways modulates Al2O3-NPs-induced apoptosis in HepG2 cells. Novel mechanisms behind embryonic hepatotoxicity, cytotoxic potentiating effects, and possible prevention strategies have been explored.Recently, with efficient methods of cultivating microalgae at hand, researchers and investors have paid considerable attention to the production of different environmentally friendly biofuel products. In this study, a two-stage deterministic model is proposed to design a microalgae-based biofuel and co-product supply chain network (MBCSCN). In the first stage, appropriate locations to cultivate microalgae are identified through the analytical hierarchy process (AHP). In the second stage, a deterministic mathematical mixed integer linear programming (MILP) model is developed for a period of 5 years based on economic and environmental impacts as two criteria. The economic objective function maximizes the overall profit, while the objective function of the environmental impacts seeks to minimize fossil fuel consumption throughout the supply chain. Then, a multi-objective MILP optimization problem is solved using the ε-constraint method. The proposed model is evaluated through a case study in Iran. It has helped to identify appropriate locations for the cultivation of microalgae and to specify the required quantity of feedstock, the species of microalgae, the required technology, and the transportation modes in each step of the supply chain.Coal fires refer to fires generated by the self-combustion of coal seams, which have a maximum temperature of 1000 °C. Such fires can significantly alter the properties of surrounding rock and soil. However, in Northern Shaanxi, China, coal resources are abundant, and the buried depth of coal seams is shallow; therefore, coal fires often occur. selleck Because Northern Shaanxi is located in China's Loess Plateau, there is a large amount of loess accumulation on the surface. For this reason, it is imperative to study the effects of high temperatures on loess. In this paper, the loess samples are heat treated at different temperatures (200-1000 °C), and their surface redness (a*) and mass magnetic susceptibility (χ) are measured to simulate the high-temperature effects of coal fires on the loess in northern Shaanxi, and also study its chromaticity changes and abnormal magnetic properties. The results show that (1) the loess χ value is affected by the heat-treatment temperature; at 600 °C, the χ value decreases, increasing rapidly above after 850 °C. Further, the magnetic susceptibility changes significantly. (2) The thermal-induced transformation of ferromagnetic minerals and the buried depth of loess are the main reasons for these changes in magnetic susceptibility and red chroma of loess.Endometrial hyperplasia (EH) is a complex condition that commonly affects women after menopause. Since the current available treatments for EH are mainly invasive, there is a need for developing new treatment modalities. Chrysin (Ch) is a dihydroxyflavone with numerous promising therapeutic potentials. In this study, Ch's protective effects on estradiol (E2)-induced EH were studied in rats. Animals were allocated randomly to five groups and were treated for 4 weeks as follows Group 1, control received the vehicle; group 2, Ch received Ch 25 mg/kg; group 3, estradiol (E2) received E2 (3 mg/kg) 3 × weekly subcutaneously and the vehicle. Group 4, E2 + Ch 10 mg/kg and group 5, E2 + Ch 25 mg/kg Ch was given once daily at 10 mg/kg or 25 mg/kg, respectively. In addition, E2 was administered 3 × weekly (3 mg/kg) in groups 4 and 5. Ch inhibited the E2-induced increase in uterine weights and histopathological changes. Ch lowered the cyclin D1 expression. Ch raised the caspase-3 content and Bax mRNA expression. Furthermore, it corrected the raised Bcl2 mRNA expression due to E2. Ch inhibited MDA accumulation and GSH depletion. It also prevents E2-induced SOD and GPx exhaustion. It also ameliorated the rise in NFκB, TNF-α, and IL-6 expression. These effects were correlated with an enhanced PPARα activity ratio relative to the E2 group. This suggests that Ch attenuates EH in this model by exerting anti-proliferative, anti-oxidant, and anti-inflammatory effects partially through increasing PPARα activity.