Morinpacheco1473

Prenatal exposure to polybrominated diphenyl ethers (PBDEs) has been associated with adverse neurodevelopmental outcomes in children, but evidence remains mixed regarding sex differences in this association.

To examine the prospective association between prenatal PBDE exposure and cognitive ability in young children, as well as potential sex differences.

The study was conducted in a multi-site Canadian pregnancy cohort recruited in 2008-11. PBDEs were measured in maternal plasma samples collected early in pregnancy. Cognitive ability was assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) in children at age 3years (mean=3.4). Multiple linear regression was used to analyze the association between maternal PBDE plasma concentrations (lipid-standardized and log10-transformed) and Verbal, Performance, and Full Scale IQ scores on the whole sample and stratified by sex, adjusting for confounders.

The sample was composed of 592 children (291 boys and 301 girls). A tenfold incrs support that exposure to PBDEs during early development may be sex-dependent and detrimental to a child's neurodevelopmental trajectory.Since its creation in 2002, the European Food Safety Authority (EFSA) has produced risk assessments for over 5000 substances in >2000 Scientific Opinions, Statements and Conclusions through the work of its Scientific Panels, Units and Scientific Committee. OpenFoodTox is an open source toxicological database, available both for download and data visualisation which provides data for all substances evaluated by EFSA including substance characterisation, links to EFSA's outputs, applicable legislations regulations, and a summary of hazard identification and hazard characterisation data for human health, animal health and ecological assessments. The database has been structured using OECD harmonised templates for reporting chemical test summaries (OHTs) to facilitate data sharing with stakeholders with an interest in chemical risk assessment, such as sister agencies, international scientific advisory bodies, and others. This manuscript provides a description of OpenFoodTox including data model, content and tools to download and search the database. Examples of applications of OpenFoodTox in chemical risk assessment are discussed including new quantitative structure-activity relationship (QSAR) models, integration into tools (OECD QSAR Toolbox and AMBIT-2.0), assessment of environmental footprints and testing of threshold of toxicological concern (TTC) values for food related compounds. Finally, future developments for OpenFoodTox 2.0 include the integration of new properties, such as physico-chemical properties, exposure data, toxicokinetic information; and the future integration within in silico modelling platforms such as QSAR models and physiologically-based kinetic models. Such structured in vivo, in vitro and in silico hazard data provide different lines of evidence which can be assembled, weighed and integrated using harmonised Weight of Evidence approaches to support the use of New Approach Methodologies (NAMs) in chemical risk assessment and the reduction of animal testing.Fiber-rich food intake has been associated with lower serum concentrations of perfluoroalkyl substances (PFAS) in some studies and dietary fiber was related to lower serum PFAS in a recent study. Given the previous epidemiologic data suggesting that fiber might decrease serum PFAS concentrations, we examined the relation of serum PFAS concentrations to intake of dietary fiber in National Health and Nutrition Examination Survey (NHANES) data. We examined the PFAS-fiber association among 6482 adults who participated in the NHANES, 2005-2016. Fiber intake was estimated based on two 24-hour diet recalls. We adjusted the models for determinants of PFAS and potentially confounding factors such as intake of foods reported to increase PFAS exposure. Results were expressed as the percent difference in PFAS concentration per interquartile range (IQR) increase in fiber (and 95 percent confidence interval), and the NHANES sampling parameters were used to make the results generalizable to the U.S. TAK 165 cell line The adjusted percent difference in perfluorooctanoic acid (PFOA) per IQR increase in fiber was -3.64 (-6.15, -1.07); for perfluorooctane sulfonic acid (PFOS) was -6.69 (-9.57, -3.73), and for perfluorononanoic acid (PFNA) was -8.36 (-11.33, -5.29). These results suggest that dietary fiber increases the gastrointestinal excretion of PFOA, PFOS, and PFNA. Because fiber also lowers serum cholesterol, in some studies of the serum cholesterol-PFAS relationship confounding by fiber may be worth evaluating.In this study, a boron-doped diamond (BDD) electro-oxidation technology coupled with nanofiltration membrane (EO-NF) technology was investigated for its effectiveness in removing antibiotics (i.e., sulfamethazineSMZ) and mitigating biofouling during secondary wastewater treatment. The result showed that EO obtained an effective SMZ removal, owing to the ·OH generation observed by Electron paramagnetic resonance (EPR) analysis; complete elimination of SMZ was found under the high current density (30 mA/cm2) and long Electrolysis Time (ET = 60 min). Meanwhile, EO-NF process enabled to reduce COD content from 60 mg/L to nearly 5 mg/L. Furthermore, regardless of the effect of EO process, NF could retain most NH3-N because of the excellent performance of NF for ions rejection, and its permeate concentration was below 0.5 mg/L. EO was able to reduce membrane fouling notably, increasing the final flux (15 L/(m2·h)) of NF by 25.1% during long-term operation (240 h). Scanning electron microscopy-Energy dispersive spectrometry (SEM-EDS) showed that a porous layer formed on the vicinity of NF membrane in the case of filtrating EO effluent, in contrast to a uniform and dense biofouling layer generated during the direct NF. Besides, the content of adenosine triphosphate (ATP) and the number of bacterial colonies in the retentate of the EO-NF process were greater than those of the direct NF process. This resulted in a smaller amount of extracellular polymeric substances (EPS) attaching to the membrane surface, decreasing the tightness and hardness of the fouling layer in the case of EO, as indicated by CLSM analysis. Overall, considering its ability to effectively eliminate persistent contaminants and reduce membrane fouling, BDD-based EO is considered a promising pre-treatment option for future NF applications.