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Increased expression of DPP4 could be a promising index for determining the prognosis of glioma.The human gut pathogen, Salmonella Typhimurium (S. Typhimurium) not only survives but also replicates inside the phagocytic cells. Bacterial proteins are the primary targets of phagocyte generated oxidants. Because of the different amino acid composition, some proteins are more prone to oxidation than others. Many oxidant induced modifications to amino acids have been described. Introduction of carbonyl group is one of such modifications, which takes place quite early following exposure of proteins to oxidants and is quite stable. Therefore, carbonyl groups can be exploited to identify oxidant susceptible proteins. Tofacitinib mw Hypochlorous acid (HOCl) is one of the most potent oxidants produced by phagocytes. Incubation of S. Typhimurium with 3 mM HOCl resulted in more than 150 folds loss of bacterial viability. Proteins extracted from HOCl exposed S. Typhimurium cells showed about 60 folds (p  less then  0.001) more carbonyl levels as compared to unexposed cells. Similarly, 2, 4-Dinitrophenylhydrazine (2, 4-DNPH) derivatized proteins of HOCl treated S. Typhimurium cultures reacted strongly with anti-DNP antibodies as compared to buffer treated counterpart. Next, we have derivatized carbonyl groups on the proteins with biotin hydrazide. The derivatized proteins were then isolated by avidin affinity chromatography. Mass spectrometry based analysis revealed the presence of 204 proteins.The Thraupidae family is one of the most wanted by bird breeders in Brazil because it is represented by its diverse, colorful and melodious singers. The Great-billed Seed-finch, Sporophila maximiliani, is the only representative of the genus Sporophila considered critically endangered in Brazil. Due to the demands of environmental agencies and of conservation programs, there is a need to increase the number of molecular markers available for the genus and specially for S. maximiliani. Therefore, this work aimed to provide a new set of microsatellite markers for S. maximiliani in order to help bird breeders and environmental agencies on fulfilling its demands as well as contributing with extra genetics tools for conservation programs of the S. maximiliani. Of the 30 markers developed, 25 successfully amplified, and 22 were polymorphic. Annealing temperature varied from 52 to 64 °C, number of alleles from 2 to 13, and the medium allele richness was 7.25 and medium expected, observed heterozygosity and PIC were, respectively, 0.812, 0.661 and 0.752. The probability of identity estimate was 8.54 × 10-27 and all the other probabilities of non-exclusion (sib-identity, parent pair and first-parent) were  less then  0.001, indicating that this set of microsatellite markers have high genetic variability and high power of individual genetic differentiation for S. maximiliani. Therefore, this work increases the options of molecular markers to be used on inspection for environmental agencies and for conservation programs on analyzing genetic variability and population studies for S. maximiliani.This study aimed to determine the association between spiritual well-being and resilience among Turkish hemodialysis patients. This cross-sectional study was conducted with 134 hemodialysis patients treated at two state hospitals' hemodialysis units between February 2019 and July 2019. The data were collected with a Personal Information Form, the Spiritual Well-Being Scale and the Resilience Scale for Adults with the face-to-face interview technique. To analyze the data, descriptive statistics, t tests, ANOVA, Pearson's correlation and multivariate linear regression analysis were used. The patients' spiritual well-being levels were high, while their psychological resilience levels were medium. There was a moderate positive correlation between spiritual well-being and resilience (p  less then  0.01). Education level, economic level, duration of disease and spiritual well-being were determined to be statistically significant predictive factors of the patients' resilience (p  less then  0.001). In this context, nurses may provide psychosocial and spiritual care, education and counseling services that will increase patient's resilience.This study was conducted on 82,908 records of purebred and upgraded Kashmir Merino sheep to evaluate the performance of breed over the years. The data pertaining to fiber diameter (FD), staple length (SL), clean wool yield percent (CWY %), number of crimps/cm (NCPC), and medullation percent (MP) spread over a period of 15 years (2013-2017) was collected from Fleece Testing Laboratory Nowshera, Srinagar. The highest CV (%) was observed for MP, whereas the lowest CV (%) was observed for FD (2.07%). The least-squares means were 20.96 ± 0.002 μm, 4.05 ± 0.01 cm, 66.68 ± 0.01%, 4.38 ± 0.02 No/cm and 0.79 ± 0.05% for FD, SL, CWY (%), NCPC and MP, respectively. The year of shearing had highly significant (p  less then  0.01) effect on all the traits under the study. The study concludes that crossbreeding with exotic fine wool breeds has resulted improved genetic potential of native germplasm with respect to wool quality traits with Merino sheep performing better in the agro-climatic conditions of the State. Environment was also found to play a significant role in expression of wool quality traits during the period of the study.The association between atrial fibrillation (AF) and thromboembolic (TE) complications in left ventricular assist device (LVAD) recipients is controversial, and there is paucity of large-scale data evaluating the impact of AF on early outcomes after device implantation. Using the National Inpatient Sample, we identified hospitalizations where patients underwent LVAD implantation from 2010 to 2015. Multivariate logistic regression was used to evaluate the association of AF on in-hospital outcomes. A total of 18,378 patients (41.7% with AF) underwent LVAD implantation. Patients with AF were older (59.9 vs. 54.0 years, p  less then  0.001), more commonly male (79.9 vs. 74.1%, p  less then  0.001), and had a greater burden of comorbidities as measured by the Elixhauser comorbidity index (7.2 vs. 6.3, p  less then  0.001). Patients with AF had less incidence of ischemic stroke (3.1 vs. 4.7%, p = 0.04, OR 0.68), hemorrhagic stroke (1.0 vs. 2.4%, p = 0.006, OR 0.43), and other systemic embolism (1.8 vs. 3.7%, p = 0.