Millslyon1357

ever, a significant decrease in cognition levels was detected following an increase in IR scores of the AD patients.

Acute Graft Versus Host Disease (GVHD) affects about 20%-80% of the patients after the hematopoietic stem cell transplant (HSCT) and it is amongst the main causes of morbidity and mortality both in children and adults. The intestine is one of the most affected organs by GVHD causing important alterations in the nutritional status and quality of life, considering that the dysfunctional intestine could decrease food intake as well as an inappropriate dietary plan could worsen the clinical condition. In addition to GVHD, chemotherapy conditioning regimen suppresses the immune system, promotes mucositis and increases the risk of infectious complications. Taking the above into consideration, when per oral diet is possible; the food choices should be carefully planned and monitored to promote nutritional support and avoid worsening the intestinal function and clinical condition.

This work was aimed to present a practice guideline proposal, to be validated, based on literature review, regarding to oral dietary rWe could not demonstrate confidence in the effect estimate based on the selected study. However, considering the lack of literature information and the relevance of the topic, we decided to proceed and propose a practice guideline for an oral diet protocol for acute intestinal GVHD as a reference to be a starting point to validate protocols in future clinical trials. 2 Practice Guideline Proposal The criteria to elaborate the protocol were based on the RIGHT Statement. In addition to the literate information about diet and intestinal health, recommendations already adopted in the Service of Bone Marrow Transplant in the Complex Hospital of Clinics of Curitiba, in the state of Paraná, Brazil, were also considered.

Quality indicators are important tools in clinical practice for assessing and monitoring the quality of care in nutritional therapy. Application of these indicators can improve care and may help to decrease the high frequency of malnutrition and associated hospital costs. Therefore, the purpose of the present study was to estimate the frequency of oral nutritional supplements (ONS) use and to evaluate compliance with the four available quality indicators in oral nutritional therapy (QIONT) in a university hospital.

A prospective study was conducted from November 2017 to May 2018, using data from all patients with an ONS prescription aged 18 years or older admitted to the medical clinical or surgical clinical wards. Four indicators were investigated, as recommended by the International Life Science Institute.

Of the 727 hospitalized patients in the included wards, 214 were on ONS. The frequency of ONS prescription was 29.4%. Of the 4 QIONT evaluated, none achieved the goals frequency of subjective global assessment and reassessment nutritional (48.1% and 5.6%, respectively); frequency of non-compliance for the indication of ONS (73.36%); and fasting over 24h during ONS (50%).

A high frequency of non-compliance (100% of QIONT) was observed in hospitalized patients on ONS in medical clinical and surgical clinical wards. These results will enable health professionals in the evaluated service to elaborate protocols to improve the evaluation and recording of the nutritional follow-up of hospitalized patients on ONS. This will help to improve the quality of nutritional care.

A high frequency of non-compliance (100% of QIONT) was observed in hospitalized patients on ONS in medical clinical and surgical clinical wards. These results will enable health professionals in the evaluated service to elaborate protocols to improve the evaluation and recording of the nutritional follow-up of hospitalized patients on ONS. This will help to improve the quality of nutritional care.

The effects of ileostomy construction and colonic bypass on the general nutritional status of the patients have not yet received much attention. The aim of the present study was to assess the effect of a diverting ileostomy formation, on the nutritional intake, body composition and nutritional status biochemical markers of patients with a newly formed ileostomy.

This was an observational study. Patients scheduled for elective rectosigmoid resection at a surgical unit of a public university hospital, were considered for study inclusion. Patients in whom a diverting ileostomy was created were assigned to the ileostomy group (n=41), and patients who underwent rectosigmoid resection without requiring a diverting ileostomy served as a control group (n=37). EGF816 in vitro Anthropometric characteristics, body composition, dietary intake and biochemical markers representative of nutritional status were assessed preoperatively and at 40 days postdischarge (NCT02036346).

Anthropometric and body composition characteristics (weigt need to be included in the routine clinical management of this patient category to prevent weight loss and impaired energy intake.

Assessment of malnutrition, performance status and systemic inflammation are routine aspects of clinical assessment in patients with advanced cancer. There is increasing evidence that body composition measurements from routine staging CT also have prognostic value. To date the relative prognostic value of Malnutrition Universal Screening Tool (MUST), Eastern Cooperative Oncology Group Performance Status (ECOG-PS), modified Glasgow Prognostic score (mGPS) and CT derived body composition analysis in patients with advanced lung cancer has not been examined. The aim of the present study was to examine this relationship.

Clinicopathological characteristics including MUST, ECOG-PS, mGPS and body composition data were collected pre-radiotherapy from a prospectively maintained database of patients with advanced lung cancer (n=643). Using the MUST score, patients were classified into low (MUST=0, n=189), medium (MUST=1, n=341) and high (MUST≥2, n=113) malnutrition risk and their relationship to systemic inflammatol survival. MUST, ECOG-PS and mGPS all had independent prognostic value and may form an important prognostic framework in treatment decision making and resource utilization.

A large proportion of patients (71%) with advanced lung cancer were at moderate to high nutrition risk. Higher malnutrition risk and elevated inflammatory status were independently associated with poor overall survival. MUST, ECOG-PS and mGPS all had independent prognostic value and may form an important prognostic framework in treatment decision making and resource utilization.

Sarcopenic obesity (defined as low muscle mass and strength with high adiposity) requires attention in adults with advanced knee osteoarthritis (OA) due to implications on treatment outcomes. This study aimed to identify muscle function measures and patient characteristics associated with the presence of low muscle mass that could be used to screen and detect sarcopenic obesity in patients with knee OA in the clinical setting.

Cross-sectional study of patients with knee OA and a body mass index (BMI) ≥30kg/m

. Body composition was measured in n=151 patients (59% female, mean age 65.1±7.9 years) using dual-energy x-ray absorptiometry. Appendicular skeletal muscle mass (ASM) adjusted by BMI and below established sex-specific cut-points was used to differentiate low muscle mass. Muscle function was assessed by 4-m gait speed, 6min walk test, and maximal grip strength (absolute, and relative, adjusted by BMI). Logistic regression was used to assess the relationship between muscle function measures, patient characteristics, and low muscle mass. Receiver operating characteristic curves and area under the curve (AUC) were used to examine the final model and identify potential clinical cut-points.

Sex and relative grip strength were associated with low muscle mass (AUC 0.774, p<0.001). Cut-points for low relative grip strength (<0.65kg/m

in females and <1.1kg/m

in males) were distinguished and used in combination with low muscle mass to screen and identify sarcopenic obesity. Patients with both low relative grip strength and low muscle mass (sarcopenic obesity) had impaired mobility and quality of life.

Relative grip strength shows promise as a clinical screening measure for sarcopenic obesity in patients with knee OA.

Relative grip strength shows promise as a clinical screening measure for sarcopenic obesity in patients with knee OA.

Apos play a role in lipoprotein metabolism. Several studies have been carried out on the effect of chromium supplement in improving CVD risk factors.

This study is a systematic review and meta-analysis that aimed to investigate the effect of chromium supplementation on Apos levels of human studies.

We searched PubMed, Scopus up to May 2020 up to September 2019. We retrieved studies from identified articles. The studies' quality was evaluated using Cochrane Risk of Bias Tool. We estimated the effect of chromium supplementation on Apo A, Apo A1, and Apo B by pooling mean and standard deviation (SD) values.

We obtained six trials involving 231 participants. Chromium consumption resulted significantly decreased Apo B while the subjects were ingesting chromium picolinate. Chromium supplementation did not significantly decrease Apo A (WMD-3.89mg/dl; 95% CI,-11.96 to 4.18) with no significant heterogeneity (I

=0.00%, p=0.37). The serum level of Apo A1 did not statistically change following chromium intervention (WMD 6.11mg/dl; 95% CI,-7.01 to 19.23) with no significant heterogeneity (I

=0.00%, p=0.68). Chromium supplementation did not significantly decrease Apo B (WMD 3.81mg/dl; 95% CI,-5.32 to 12.94). With no significant heterogeneity (I

=42.3%, p=0.12).

The chromium supplement did not have a significant effect on the Apolipoproteins (Apo A, ApoA1 and Apo B).

The chromium supplement did not have a significant effect on the Apolipoproteins (Apo A, ApoA1 and Apo B).

Malnutrition is associated with Cystic Fibrosis (CF) disease progression. That contributes to decreased lung function, poor quality of life, and increased morbidity and mortality. Appetite stimulants (AS) have been used to help increase caloric intake. When caloric intake is inadequate, gastrostomy tube (GT) feeding is offered and has shown to improve weight gain. In some patients, both AS and GT placement might not be adequate to insure weight gain. That could be due to the underlying psychopathological issues like anxiety and depression that are common in CF.

To address malnutrition in CF.

Since increasing oral caloric intake was inadequate to improve weight gain. AS and GT feeding were discussed and offered. AS was started, but was not used regularly. However, GT was still needed to improve weight gain. Because of patient's hesitations, ongoing psychological counseling was done to help patient accept the intervention.

Addressing patient's depression and anxiety and the failure to gain adequate weight at the same time helped improving patient's nutritional status.

The presented case report demonstrates the improvement in weight gain and body mass index in a CF patient after addressing both the patient's psychological needs and increasing caloric intake through gastrostomy tube feeding.

The presented case report demonstrates the improvement in weight gain and body mass index in a CF patient after addressing both the patient's psychological needs and increasing caloric intake through gastrostomy tube feeding.