Mercerohlsen2391

As the course of the disease is uncertain, the goal of this article is to assist others in preparation for what may come next with COVID-19 as well as potential future pandemics.Cases of coronavirus disease 2019 (COVID-19) are escalating rapidly across the globe, with the mortality risk being especially high among those with existing illness and multi-morbidity. The immunosuppressed status of some cancer patients increases their risk of infection compared with the general population, and cancer treatment within 2 weeks of COVID-19 diagnosis was reported as a risk factor for developing severe events. Palliative care workers have an essential role in the response to COVID-19 by responding rapidly and flexibly; ensuring protocols for symptom management are available, considering redeploying staffs and volunteers to provide psychosocial and bereavement care and using technology to communicate with patients and carers.

Reproductive decline due to parental age has become a major barrier to fertility as couples have delayed having offspring into their thirties and forties. Advanced parental age is also associated with increased incidence of neurological and cardiovascular disease in offspring. Thus, elucidating the etiology of reproductive decline is of clinical importance.

Deciphering the underlying processes that drive reproductive decline is particularly challenging in women in whom a discrete oocyte pool is established during embryogenesis and may remain dormant for tens of years. Instead, our understanding of the processes that drive reproductive senescence has emerged from studies in model organisms, both vertebrate and invertebrate, that are the focus of this literature review.

Studies of reproductive aging in model organisms not only have revealed the detrimental cellular changes that occur with age but also are helping identify major regulator proteins controlling them. Here, we discuss what we have learned from model organisms with respect to the molecular mechanisms that maintain both genome integrity and oocyte quality.

Studies of reproductive aging in model organisms not only have revealed the detrimental cellular changes that occur with age but also are helping identify major regulator proteins controlling them. Here, we discuss what we have learned from model organisms with respect to the molecular mechanisms that maintain both genome integrity and oocyte quality.Educational large-scale studies typically adopt highly standardized settings to collect cognitive data on large samples of respondents. Increasing costs alongside dwindling response rates in these studies necessitate exploring alternative assessment strategies such as unsupervised web-based testing. Before respective assessment modes can be implemented on a broad scale, their impact on cognitive measurements needs to be quantified. Therefore, an experimental study on N = 17,473 university students from the German National Educational Panel Study has been conducted. Respondents were randomly assigned to a supervised paper-based, a supervised computerized, and an unsupervised web-based mode to work on a test of scientific literacy. Mode-specific effects on selection bias, measurement bias, and predictive bias were examined. The results showed a higher response rate in web-based testing as compared to the supervised modes, without introducing a pronounced mode-specific selection bias. Analyses of differential test functioning showed systematically larger test scores in paper-based testing, particularly among low to medium ability respondents. Prediction bias for web-based testing was observed for one out of four criteria on study-related success factors. Overall, the results indicate that unsupervised web-based testing is not strictly equivalent to other assessment modes. 2-Bromohexadecanoic However, the respective bias introduced by web-based testing was generally small. Thus, unsupervised web-based assessments seem to be a feasible option in cognitive large-scale studies in higher education.The representation of abstract concepts remains a challenge, justifying the need for further experimental investigation. To that end, we introduce a normative database for 630 semantically similar French word pairs and associated levels of abstractness for 1260 isolated words based on data from 900 subjects. The semantic similarity and abstractness norms were obtained in two studies using 7-point scales. The database is organised according to word-pair semantic similarity, abstractness, and associated lexical variables such as word length (in number of letters), word frequency, and other lexical variables to allow for matching of experimental material. The associated variables were obtained by cross-referencing our database with other known psycholinguistic databases including Lexique (New et al., 2004), the French Lexicon Project (Ferrand et al., 2010), Wordlex (Gimenes & New, 2016), and MEGALEX (Ferrand et al., 2018). We introduced sufficient diversity to allow researchers to select pairs with varying levels of semantic similarity and abstractness. In addition, it is possible to use these data as continuous or discrete variables. The full data are available in the supplementary materials as well as on OSF ( https//osf.io/qsd4v/ ).The time-efficient assessment of moral values using systematically validated measures is a high priority in moral psychology research. However, few such options exist for researchers working with Moral Foundations Theory, one of the most popular theories in moral psychology. Across two samples totaling 1336 participants (756 Australian undergraduates and 580 American Mechanical Turk workers), we used a genetic algorithm-based (GA) approach to construct and validate abbreviated versions of the Moral Foundations Vignettes (MFV), a 90-item scale comprising vignettes of concrete violations of each of the six moral foundations. We constructed 36- and 18-item versions of the MFV, demonstrating close correspondence with the complete MFV, and adequate reliability, predictive validity, and factor-analytic goodness of fit for both abbreviated versions. Overall, the abbreviated scales achieve substantially reduced length with minimal loss of information, providing a useful resource for moral psychology researchers.