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On February 12, 2021, Ivan I. Dedov, Academician of the Russian Academy of Sciences, an outstanding scientist with a worldwide reputation, celebrates his anniversary. Ivan I. Dedov is a leading clinician, endocrinologist, teacher, experienced organizer of healthcare in Russia. Ivan I. Dedov headed the Russian endocrinology at a difficult stage of its development. Under his leadership, clinical endocrinology, a narrow, largely secondary field, has now acquired the significance of a fundamental and priority clinical discipline.The editorial board of the journal «Problems of Endocrinology» cordially congratulates its editor-in-chief and wishes him good health and many fruitful years for the benefit of Russian endocrinology.Research suggests that working during traumatic events can lead to deteriorating physical and mental health for nurses, a phenomenon that has been demonstrated during the coronavirus 2019 (COVID-19) pandemic. However, research has also shown that there are evidence-based strategies that can be used to assist nurses in their recovery from such events. Promoting awareness among individual nurses about the effects of COVID-19 enables them to adopt positive coping strategies, both on an individual and organisational level. This article details strategies including formal and informal debriefing, taking regular breaks, and using stress mitigation strategies during shifts. The article also discusses the potential for post-traumatic psychological growth. This acknowledges that while working in a healthcare environment during COVID-19 can be extremely challenging, it also enables nurses to experience personal growth such as the development of emotional intelligence. As nurses adapt to the 'new normal' of working during COVID-19, healthcare organisations should ensure that they provide nurses with the support that enables them to recover effectively.

Neonatal intensive care unit (NICU) music therapy is an emerging discipline. There is a growing evidence base supporting its use, with an emphasis on the immediate and short-term positive effects on infants' physiological responses and parents' experiences.

To explore the implementation of music therapy aligned with standards of neonatal care and as an integral part of the care routinely provided in a Norwegian NICU.

Parents of infants hospitalised in the NICU were offered music therapy sessions based on the First Sounds Rhythm, Breath and Lullaby model. Before discharge from the NICU, parents were asked to complete an electronic survey about their experiences of music therapy. Nurses' feedback and observations were also elicited and collected.

A total of 16 parents completed the survey. Overall, their experiences of music therapy were positive, and they noted several benefits for themselves and their infant. In addition, nurses observed that parents' interactions with their infant increased after participation in music therapy. However, nurses reported it was challenging to invite parents to participate in music therapy at a time of uncertainty, anxiety and grief. Nurses also found it challenging to disseminate information about music therapy to parents from other cultures. Furthermore, it was identified that most parents learned about the music therapy sessions from the music therapist, rather than from NICU medical or nursing staff, which indicates that music therapy was not fully integrated among the unit's multidisciplinary team.

Music therapy can reinforce family-centred care and promote parent-infant bonding, but additional efforts are required to integrate it into the care routinely provided by the NICU multidisciplinary team.

Music therapy can reinforce family-centred care and promote parent-infant bonding, but additional efforts are required to integrate it into the care routinely provided by the NICU multidisciplinary team.Globally, every 30 seconds a lower limb amputation is carried out due to diabetes, in 85 % of cases preceded by a foot ulcer. One of the main causes of foot ulcer formation is abnormal mechanical pressure and shear, the alleviation of which is therefore a key element in the management of diabetic foot ulcers. The toes, often neglected in routine clinical examinations, are particularly vulnerable because of the thin soft tissue between the bones and the skin and because of trauma due to ill-fitting shoes. The orthosis described in this article provides effective protection of protruding and injured areas while being comfortable to wear with everyday shoes and compatible with an active lifestyle. When correctly designed, worn and monitored, it has the potential to prevent and heal diabetic ulcers of the Hallux and the lesser toes.Medical students from the University of Lausanne volunteered rapidly and in great number to bolster health facilities across Switzerland in response to the COVID-19 pandemic. At Unisanté, Center for general practice and public health, University of Lausanne, students recruited as interns discovered the different aspects of primary care. This extraordinary period naturally involves considerable challenges but represents also a precious learning opportunity for future doctors.Patients suffering from burns, especially when they are extensive, benefit from specialized multidisciplinary care at the Lausanne University Hospital. In recent decades, major advances in medical research have made possible a significant reduction in morbidity and mortality. At the same time, the psychological needs of those patients have continued to increase, with the need for professional and individualized care. Intervention by the liaison psychiatrist face the challenge of integration within the complex somatic care.Ketamine and its S-enantiomer, esketamine, have shown to be promising molecules for use in psychiatry. Widely investigated for the treatment of drug-resistant depression, they could be used in emergency conditions, due to their rapid onset of action, in two main conditions 1) psychomotor agitation, and 2) acute suicidal ideation and behavior (suicidal crisis). In particular, intranasal administration offers a non-invasive, safe and very easy to administer option. An effect begins a few hours to a day after intake and lasts for about a week. These molecules present an innovative option for the future and their specific use in psychiatric emergencies.The diagnosis of factitious disorder can only emerge when caregivers are in difficulty in caring for their patient. This disorder is a real challenge for healthcare teams throughout the treatment, from its discovery to its treatment. Secrecy and self-inflicted injuries are components that we can be uncomfortable with as caregivers. The factitious problem requires well-coordinated care between the various specialists and often questions our practices. In this article we deal with the questions frequently asked by the care teams to the liaison psychiatrists that we are, by working on the identification of the problem in the clinic, the therapeutic issues and the attitude to adopt.Chronic pain is a complex phenomenon that includes three dimensions biological, socio-cultural and psychological. The psychological aspect plays an amplifying role in the perception of pain and therefore, adjuvant psychotherapies are an important tool in the multidimensional management of chronic pain. In this article, we present the main psychotherapeutic approaches and techniques applied in the field of chronic pain which act on the cognitive-emotional, traumatic, as well as on the sensory level. The personalization of psychotherapeutic treatment, as well as the involvement of patients in its choice, should allow psychotherapeutic approaches to achieve their goal in terms of improving the quality of life of patients.The context of the clinical encounter, and more generally of the practice of medicine, has effects on physicians. For example, it shapes their opinions, discourses, and ultimately their behaviors. The context may also directly impact physicians, sometimes affecting their physical and mental health. Numerous interventions, provided within and outside the institution, are targeting these effects. The question we raise in this article is should physicians adapt to, or should they rather situate themselves within, their context. This question leads us to discuss reflexivity and reflexivity training.Patients and their clinical predicaments have an impact on clinicians (that psychoanalysis frames as countertransference), but also on medical institutions. Suicidal patients provide a potent illustration of such phenomena. At the individual level, they evoke intense, often negative affective reactions. At the institutional level, they are also « difficult » patients, who often do not conform to the classical, « expected » sick role. This can result in policies too focused on risk assessment and strict procedures, potentially detrimental to proper care. To prevent such defensive attitudes, institutions should provide clinicians an environment in which they are able to work through their relationships with patients, but also with the medical profession and institutions.

Human exome sequences contain 15,000-20,000 variants but many variants have unknown clinical impact. In silico predictive classifiers are recognized by the American College of Medical Genetics as a resource for interpreting these "variants of uncertain significance." Many in silico classifiers have been developed, of which PolyPhen-2 is highly successful and widely used. PolyPhen-2 uses a naïve Bayes model to synthesize sequence, structural and genomic information. I investigated whether predictive performance could be improved by replacing PolyPhen-2's naïve Bayes model with alternative machine learning methods.

Classifiers using the PolyPhen-2 feature set were retrained using extreme gradient boosting (XGBoost), random forests, artificial neural networks, and support vector machines. Classifiers were externally validated on "pathogenic" and "benign" ClinVar variants absent from the training datasets. Software is implemented in Python and is freely available at https//github.com/djparente/polyboost and the Python Package Index (PyPI) under the BSD license.

An XGBoost-based classifier-designated PolyBoost (PolyPhen-2 Booster)-improves discriminative performance and calibration relative to PolyPhen-2 in external validation on ClinVar.

PolyBoost analyzes PolyPhen-2 output and can be incorporated into existing bioinformatics workflows as a post-analysis method to improve interpretation of clinical exome sequences obtained to identify monogenic disease.

PolyBoost analyzes PolyPhen-2 output and can be incorporated into existing bioinformatics workflows as a post-analysis method to improve interpretation of clinical exome sequences obtained to identify monogenic disease.

Observational studies have consistently reported that serum urate positively correlates with bone mineral density (BMD). The aim of this study was to determine whether moderate hyperuricaemia induced by inosine supplements influences bone turnover markers in post-menopausal women over a six-month period.

One hundred and twenty post-menopausal women were recruited into a six-month randomised, double-blind, placebo-controlled trial. Key exclusion criteria were osteoporosis, previous fragility fracture, bisphosphonate therapy, gout, kidney stones, and urine pH ≤5.0. selleckchem Participants were randomised 11 to placebo or inosine. The co-primary endpoints were change in procollagen type-I N-terminal propeptide (PINP) and change in β-C-terminal telopeptide of type I collagen (β-CTX). Change in BMD measured by dual-energy x-ray absorptiometry was an exploratory endpoint.

Administration of inosine led to a significant increase in serum urate over the study period (P<0.0001 for all follow-up time-points). At week 26, the mean change in serum urate was +0.