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Further studies will likely need to include multiple assessments to gain a more complete understanding of proprioception.Micromotion can accelerate fracture healing, with critical parameters being range of motion, frequency of motion, duration of motion, as well as initial timing of the motion. However, these parameters of micromotion have not been optimized. It is because in previous studies large animals were used. The displacement among fracture fragments caused by animal activity brings a considerable systemic error to experimental data. Also, the sample size is limited by time and cost. Thus, the rat with femur fracture can be a good animal model in investigating this problem as its advantages on high consistency of experimental results, short convalescence, and low maintenance cost. The challenge in using a small animal model in the micromotion study include 1) highly specific stiffness of the fixator; 2) lightweight fixator to bring less interference to animal's activity; 3) high accuracy on measurement method. This study aims to solve this problem by integrating 1) an aluminum fixator with a solid construction; 2) a modularized experimental device with dismountable parts; 3) a non-contact measurement model based on video identification technology. Our preliminary validation results confirmed the reliability and reproducibility of the external fixation device used in the investigation on the effect of applied micromotion on bone healing.Chronic Neck Pain (CNP) can be associated with biomechanical changes. This paper investigates the changes in patterns of walking kinematics along a curvilinear trajectory and uses a specially designed feature space, coupled with a machine learning framework to conduct a data-driven differential diagnosis, between asymptomatic individuals and those with CNP. For this, 126 kinematic features were collected from seven body segments of 40 participants (20 asymptomatic, 20 individuals with CNP). D-Lin-MC3-DMA mouse The features space was processed through a Neighbourhood Component Analysis (NCA) algorithm to systematically select the most significant features which have the maximum discriminative power for conducting the differential diagnosis. The selected features were then processed by a K-Nearest Neighbors (K-NN) classifier to conduct the task. Our results show that, through a systematic selection of feature space, we can significantly increase the classification accuracy. In this regard, a 35% increase is reported after applying the NCA. Thus, we have shown that using only 13 features (of which 61% belong to kinematic features and 39% to statistical features) from five body segments (Head, Trunk, Pelvic, Hip and Knee) we can achieve an accuracy, sensitivity and specificity of 82.50%, 80.95% and 84.21% respectively. This promising result highlights the importance of curvilinear kinematic features through the proposed information processing pipeline for conducting differential diagnosis and could be tested in future studies to predict the likelihood of people developing recurrent neck pain.Physical therapy efficacy relies on patient compliance and motivation. However, the monotony, intensity, and expense of most therapy routines do not promote engagement. Technology-based rehabilitation has the potential to provide engaging and cost-effective treatment, leading to better compliance and mobility outcomes. We present an interactive rehabilitation robot (iRebot) as an affordable, gesture-controlled vehicle that can provide a form of entertainment while conducting physical therapy. Healthy participants (n=11) executed a test maze with the iRebot for six repeated trials, three with each hand. Survey scores and quantitative metrics were evaluated to assess system usability and baseline motor performance, respectively. Wrist mobility across participants was evaluated, with an active range of motion of 39.7± 13° and 72.8± 18° for pitch and roll, respectively. In the course of conducting a single trial (time duration=87.2±67 sec), the participants performed on average 30 full wris t motion repetitions (e.g., flexion/extension). Participants rated the system's usability as excellent (survey score 85 ± 13), and all participants indicated they would prefer iRebot over standard therapy. The iRebot demonstrated potential as an evidence-based rehabilitation tool based on excellent user ratings and the ability to monitor at- home compliance and motor performance.Oxygen therapy is provided in neonatal intensive care units to prevent and treat neonatal hypoxia. This treatment is essential for the physiological development and survival of neonates with respiratory dysfunctions. One method of providing oxygen therapy involves the use of a simple face mask to deliver oxygen-enriched medical air. In these systems, a flow meter is used to adjust the volumetric flow rate of the gas between 5 to 15 L/min. If the flow rate falls below 5 L/min, there is a risk for exhaled carbon dioxide to accumulate in the mask and cause hypercapnia. Several potential hazards have been identified in the configuration of these oxygen therapy systems in neonatal intensive care units that can result in a decrease of flow rate measurement accuracy the use of an oxygen flow meter to deliver a mixed gas, the orientation of how the flow meter is installed, and a decrease in pressure due to the use of junctions and medical gas hoses. With reduced measurement accuracy at low flow rate settings, clinical users may not be aware that flow rate may drop below 5 L/min. Furthermore, inconsistencies in physical set-up and labelling may result in the wrong gas being delivered to a neonatal patient. To ensure that patient safety is maintained in neonatal intensive care units, a best practice recommendation is provided to address these potential hazards.Although polysomnography (PSG) remains the gold standard for studying sleep in the lab, the development of wearable and 'nearable' non-EEG based sleep monitors has the potential to make long-term sleep monitoring in a home environment possible. However, validation of these novel technologies against PSG is required. The current study aims to evaluate the sleep staging performance of the radar-based Circadia Contactless Breathing Monitor (model C100) and proprietary Sleep Analysis Algorithm, both in a home and sleep lab environment, on cohorts of healthy sleepers. The C100 device was initially used to record 17 nights of sleep data from 9 participants alongside PSG, with a subsequent 24 nights of PSG data for validation purposes. Respiration and body movement features were extracted from sensor data, and a machine learning algorithm was developed to perform sleep stage prediction. The algorithm was trained using PSG data obtained in the initial dataset (n=17), and validated using leave- one-subject-out cross-validation.

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