Meldgaardtopp6745

58% of diabetics under herbal medicine had slightly unbalanced diabetes with HbA1c > 7. The difference between the total cholesterol, ASL and ASP parameters of the two populations was not significant. The study of correlation showed that the consumption of plant had an effect on the type of correlation between biochemical parameters of diabetic patients. Conclusions The consumption of medicinal plants did not affect the values of the measured biochemical parameters, while the correlation between these parameters can be modified.Background A complex community of microorganisms in the gastrointestinal (GI) tract, known as the gut microbiota, exerts major effects on gene expression and cytokine profile. Extracellular vesicles (EVs) which are produced by bacteria could be sensed by Toll like receptors (TLRs). The interaction between gut microbiota and TLRs affects homeostasis and immune responses. In this study, we evaluated TLR9 gene expression and cytokines level in Caco-2 cell line treated with Lactobacillus casei as one of the gut microbiota and its EVs. Methods In the present study, L. casei derived EVs was extracted via ultracentrifugation. The quality control assessment included the evaluation of physicochemical characteristics of EVs. For the treatment of Caco-2 cell line, L. casei and its EVs (100 and 150 μg/mL) were used. In addition, qRT-PCR assay was carried out to evaluate the mRNA expression of TLR9 gene. ELISA assay was also performed to determine the levels of IFNγ, TNF-α, GM-CSF, IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, ILs on immune cells and our results in cell line level, we postulate that L. casei derived EVs could be possible candidates for the reduction of immune responses.Purpose The aim of this study was the application of International Classification of Functioning, Disability and Health Core Set (ICF- CS) of Diabetes Mellitus (DM) to investigate body function impairment (BF) & body structure (BS), activity limitation & participation restriction in people with diabetes mellitus with and without peripheral neuropathy. Method A total of 120 subjects with diabetes were interviewed using four categories of the ICF-CS of DM through ICF documentation form including body functions, body structures, activities and participation, and environmental factors. Results Subjects with diabetic peripheral neuropathy (DPN) experienced more physical dysfunctions and impairments when compared with subjects having diabetes without peripheral neuropathy when assessed with ICF-CS of DM. DPN patients experienced significant problem in 19 categories in BF, 3 categories in BS, 10 categories in activity and participation and 4 categories in environmental factors when compared with diabetes patients without peripheral neuropathy on chi square analysis. Findings of regression analysis suggest that people with DPN have more chances of impairments in BF and BS, activities and participation, and environmental factors. Conclusion The difference observed between subjects having diabetes with and without peripheral neuropathy on the scores of ICF-CS domains suggest that, people with DPN faces more problems in health and function. These people should be targeted with more intensive care for improving the health standards.Background Metabolic syndrome is defined by co-incidence of multiple metabolic disorders such as central obesity, high triglycerides, low HDL, hyperglycemia and high blood pressure, which increases the risk of cardiovascular disease and diabetes. The aim of this study was to estimate the prevalence of metabolic syndrome using Adult Treatment Panel III (ATP-III), International Diabetes Federation (IDF) and Iranian criteria in large-scaled population based cohort study and to determine the concordance between these criteria. Methods In the present study all information collected in Tabari cohort study(TCS) were utilized. These information were collected using a structural questionnaire and taking blood samples from all the participants. Blood pressure and anthropometric indices were measured for all participants by trained practitioners. Categorical variables were compared using chi-square test. In addition, the quantitative variables were compared between the two the groups using independent t-test. Kappa coefficient was estimated to show the agreement between the results of the three criteria. Results The prevalences of Metabolic syndrome were 41.10%(CI 95%40.10-42.02), 44.60%(CI 95%43.61-45.54), and 30.80% (CI 95%29.89-31.69) based on ATPIII, international IDF and IDF Iranian criteria respectively. The Kappa agreement coefficients between Iranian IDF with ATPIII definition and international IDF were estimated as 61.80% and 71.20% in the total population respectively. Elimusertib order Conclusion Kappa coefficient showed that the Iranian IDF had a good agreement with International IDF and an intermediate agreement with the ATP-III. Considering more emphasis of international and Iranian IDF on waist circumference (WC), a better agreement between these two criteria is plausible. Regarding the high prevalence of abdominal obesity among Iranian population, applying these criteria to identify high risk persons might be helpful.Objective The objective of this study was to evaluate the effects of intake of Brazil nut extract (BN) or sodium selenite solution on reproductive parameters of male diabetic animals. Methods A total of 48 Wistar rats were distributed into six groups diabetes (n = 8); diabetes and Brazil nut extract (n = 8); diabetes and sodium selenite (Na2SeO3) (n = 8); Brazil nut extract (n = 8); sodium selenite (n = 8) and control (n = 8). A single dose of streptozotocin (65 mg/kg) was injected intravenously to the rats to induce diabetes. BN or Na2SeO3 were administered by gavage for 56 days. Results The diabetes caused critical alterations on body mass gain, reproductive parameters and antioxidant capacity. Treatments with both BN or Na2SeO3 were able to increase significantly the glutathione peroxidase and the daily sperm production, both in diabetic (p less then 0.01 and p less then 0.05) and in healthy animals (p less then 0.01 and p less then 0.05). Conclusion The Brazil nut extract and sodium selenite were able to improve some reproductive parameters of diabetic rats.