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Severe pulmonary edema, secondary to left ventricular afterload increment, is a common problem occurring in patients receiving venoarterial extracorporeal membrane oxygenation. No consensus is currently available for its management, but several devices/procedures have been described, including an Impella device (Abiomed), balloon atrial septostomy, intraaortic balloon counterpulsation, or an additional venous cannula, as possible adjuncts. We report the feasibility and efficacy of the atrial flow regulator device (Occlutech) for left ventricular unloading in a 58-year-old patient receiving extracorporeal membrane oxygenation. However, the benefits of this device relative to simple balloon atrial septostomy need to be further investigated.Preventative health care is an essential part of the ownership and veterinary management of exotic animals. This article provides an overview of the current recommendations for health care and disease-prevention programs for herds or flocks of exotic animals, specifically companion and aviary birds, backyard poultry; snakes, lizards, chelonians, and amphibians; rabbits, ferrets, and common exotic small mammals. Husbandry practices, disease screening suggestions and techniques, and vaccination strategies, where appropriate, are reviewed.The management of a breeding facility of exotic species is challenging and managing these on a large scale can be a daunting task for general practitioners or novice exotic animal veterinarians. They are usually not trained to work with flocks or herds, and even most exotic animal veterinarians are used to working with single patients. This article gives some suggestions and tips on how to proceed when facing an exotic animal collection and especially when breeding is not as successful as expected.This article will focus on the diagnosis and treatment of common diseases affecting reptiles and amphibians. There will be discussions on the characteristics of each pathogen and treatment strategies based on the differences in pathogens. As the saying goes, "Prevention is better than cure". The key to successfully manage a disease outbreak is to prevent one, by that, it means to have already in place preventative measures. This will reduce the risk of a disease outbreak. Preventative measures may include source of specimen, quarantine, types of testing while in quarantine, and treatment protocols based on test results.Managing the health of reptile and amphibian collections is centered on providing appropriate environmental parameters, husbandry conditions, and nutrition as well as maintaining good welfare and careful collection planning. Disease transmission is reduced through quarantine, appropriate diagnostic testing, and annual veterinary health assessment."Management of epizootics of exotic companion mammal herds relies on careful observance of animals, proper management and husbandry, adequate nutrition, and stress reduction. Many diseases occur because of the stress of weaning so anticipating this and maximizing sanitation and ventilation, minimizing overcrowding and concurrent disease, and providing enough fiber for herbivores is prudent. Antimicrobial therapy must be carefully considered in the route of administration and the likely risk of enterotoxemia development. Separation of affected animals, rapid diagnostic testing, and implementation of treatment and supportive care minimizes losses during epizootics. Knowledge of potential zoonotic pathogens is important for veterinarians and staff.Common medical problems diagnosed and treated in individual companion exotic mammals are relevant in a herd-health setting. Many of these problems are often associated with poor husbandry and/or inappropriate nutrition. Rabbits, ferrets, chinchillas, and rodents have been domesticated alongside humans and an understanding of their ethology gives veterinarians a base knowledge in making recommendations for animals in their care. This article briefly reviews the ethology and husbandry in such species, but detailed needs are beyond the scope of this article.The modern avian practitioner may be called upon to manage disease outbreak in aviary or zoologic bird flocks. Traditionally, managing these types of disease events has been based on avicultural production principles, which may require modification to adapt to the modern leisure, educational, or exhibition aviary. We discuss how principles of avicultural medicine and disease investigation may be adapted to the aviary flock and illustrate these modified principles with real-world examples.There are many intersecting aspects to the avicultural management of a captive flock. Extensive knowledge of the natural history of the species kept is key to fulfilling the environmental, social, nutritional, and behavioral requirements of the birds, whether in a mixed- or sole-species aviary. Species compatibility with the environment, climate, and other co-occupants plays a role as well, as does hygiene, good avicultural management, and veterinary involvement and consultation. In understanding and meeting these requirements, optimal health can be maintained through the reduction or elimination of stressors and the maintenance of normal physiologic function.When treatment is required for a herd/flock health concern, a range of factors must be considered to determine the preferred treatment strategy. If a group treatment strategy is pursued, considerations to optimize the likelihood of safe and effective group treatment include taxon-specific pharmacokinetics/pharmacodynamics, the formulation of prescribed medication, the type and amount of food, the number and type of water sources, enclosure design, size and demography of the group, weather conditions, and health status of individuals in the group. In addition, antimicrobial stewardship principles and relevant legislation/regulation must be at the forefront of decision making.Against a backdrop of climate change and epidemics, the exotic animal veterinarian is well positioned to detect emerging and exotic disease threats, prevent and control zoonotic diseases, and identify antimicrobial resistance. Within the traditional context of animal and public health, epidemiology has had a focus on veterinary preventive health and in disease investigation and control particularly in food animal and safety application. The understanding of preventive health management and veterinary epidemiology expands the repertoire of the clinical veterinarian to advise and implement and evaluate group animal health programs and biosecurity measures as well as conduct disease investigations.

Craniosynostosis is a premature ossification of the fibrous sutures in a skull which results in a changing of the growth pattern of the skull with abnormal head shapes, midface hypoplasia, and neurofunctional disorders. Surgical correction of craniosynostosis by opening the ossified cranial sutures is usually made in the infant phase to avoid compression of the brain and mental deficits. However, little is known regarding the health-related quality of life among children after surgical treatment of diverse forms of craniosynostosis. The purpose of this study was to evaluate the quality of life of adolescent patients who anderwent a surgical correction of non-syndromal craniosynostosis in infancy.

The study population included 48 adolescents with an average age of 12.1±4.3 years. The KINDL questionnaire, which was specifically validated for children, was used to estimate different dimensions of quality of life and the impact of various factors on it.

In the investigated group, boys were more likely to be affected by non-syndromal craniosynostosis than were girls. Children and their parents showed a high degree of correlation in each of the investigated dimensions of the KINDL questionnaire. Sex, the type of craniosynostosis, surgical technique, and surgical result did not seem to have an influence on the quality of life. Ertugliflozin SGLT inhibitor A negative correlation between the time of surgery and the family-related quality of life could be shown. None of the patients in the study had relevant limitations or impairments in their later life.

In our study, patients with simple non-syndromic craniosynostoses who anderwent operative correction of craniosynostosis in infancy do not show any quality-of-life limitations in their later life compared to the average population.

In our study, patients with simple non-syndromic craniosynostoses who anderwent operative correction of craniosynostosis in infancy do not show any quality-of-life limitations in their later life compared to the average population.

The safety of drug use by nursing-home residents can be impaired by polypharmacy, potentially inappropriate medications (PIM), and neuroleptics, as well as by a lack of adequate interprofessional coordination in the nursing home. The goal of the HIOPP-3- iTBX Trial was to improve drug safety in nursing-home residents, including a reduction of PIM and/or neuroleptic use, by means of a complex interprofessional intervention.

This cluster-randomized, controlled trial was performed in nursing homes in Germany. Residents over age 65 were included in the trial. The intervention was carried out over six months and consisted of four elements a drug review by trained pharmacists, educational sessions for general practitioners and nurses, a drug safety toolbox, and change management seminars for members of the three participating professions. The nursing homes in the control group continued to provide usual care. The primary endpoint was the prescription of at least one PIM and/or at least two neuroleptic drugs simy in nursing homes led neither to reduced prescribing of PIM and/or neuroleptic drugs, nor to any improvement in the overall health status of the nursing-home residents.Sulfur is an essential macronutrient for plant primary metabolism. Its availability can modulate plant growth in most terrestrial ecosystems. However, its relationship with other leaf and nutrient traits, and hence its contribution to plant functioning, remains unclear. We analysed leaf and nutrient traits for 740 vascular plant species growing in a wide range of environmental conditions in Northern Italy. We determined whether leaf sulfur content per unit leaf dry mass (LSC) is associated with leaf economics spectrum, and whether its distribution among functional types (growth forms, leaf life span categories, and Grime's CSR (Competitive, Stress-tolerant, Ruderal strategies) could help to elucidate adaptive differences within plant taxa. High LSC values were mainly associated with fast-growing species representative of R- and C- strategy selection, thus the acquisitive extreme of plant economics, reflecting strong potential connections with ecosystem properties such as biomass production or litter decomposability. In general, LSC was significantly and positively correlated with leaf nitrogen content, and nitrogen to sulfur ratio was constant throughout growth forms, leaf life span and CSR strategies, and phylogenetic effects were evident. Our findings highlight that LSC variation is strongly associated with the leaf economics spectrum, suggesting that additional nutrients seldom included in functional analyses may also be embroiled within the context of plant economics. However, different ratios among nitrogen and sulfur may be expected across different plant families, suggesting that deeper insight from functional groups can provide a bridge between plant stoichiometry and ecology, useful for the evaluation of ecological responses to global change.

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