Mcneillmcintosh8795
Prognosis of cholangiocarcinoma is poor, and palliative treatment options are limited in China. This study aimed to analyze prognostic factors affecting survival in patients with advanced cholangiocarcinoma.
Clinical data on 201 consecutive patients with cholangiocarcinoma who received treatment at a single center from May 2014 to December 2018 were analyzed retrospectively. Survival curves were plotted using the Kaplan-Meier method. Survival analyses were performed using a log-rank test.
For first-line therapy, the disease control rate was 56% (85/152) and the overall response rate was 16% (24/152). The total disease control rate was 34% (23/67) for second-line therapy. The median progression-free survival was 7 months, and the median overall survival was 17 months. Next-generation sequencing was performed for 59 patients. The most frequently mutated genes were TP53 and PI3KCA. No significant association was found between gene mutations and treatment response or survival. Of 5 patients with high levels of microsatellite instability, 4 (80%) were sensitive to anti-programmed death 1 antibodies and remained in partial remission at last follow-up.
Macroscopic tumor characteristics, rather than gene mutations, determine the prognosis of advanced cholangiocarcinoma. High microsatellite instability may be a favorable predictor of response to immunotherapy for cholangiocarcinoma.
Macroscopic tumor characteristics, rather than gene mutations, determine the prognosis of advanced cholangiocarcinoma. High microsatellite instability may be a favorable predictor of response to immunotherapy for cholangiocarcinoma.
Considerable interest has developed concerning the alternative utilization of aromatic plants rich in essential oils as antibacterial agents in the medical arena. In this study, we investigated the antimicrobial activity for solutions of different concentrations of rose oil on test microorganisms known to potentially have an adverse affect on human health and the environment.
Research was carried out by the microdilution method. The test microorganisms were standard strains and clinical isolates (CIs) of Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Acinetobacter baumannii ATCC 17978, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923 and Streptococcus pneumonia ATCC 49619.
E coli was inhibited by a minimal concentration of 125 µl/ml rose oil dilution of both the standard strain and CI, B subtilis by a minimal concentration of 15.62 µl/ml and 31.25 µl/ml rose oil dilutions of the standard strain and CI, respectively, and S aureus by a minimal concentration of 31.25 µl/ml and 125 µl/ml of rose oil dilutions standard strain and CI, respectively. Thus, it was determined that rose oil could exhibit antimicrobial activity in both Gram-positive and Gram-negative bacteria.
Different percentages of diluted solutions of rose oil might be used as a preventive and therapeutic treatment for infections caused by E coli, B subtilis, and S aureus, provided that this is supported by evidence from clinical trials. Consequently, natural antimicrobial rose oil may have beneficial effects on human and environmental health.
Different percentages of diluted solutions of rose oil might be used as a preventive and therapeutic treatment for infections caused by E coli, B subtilis, and S aureus, provided that this is supported by evidence from clinical trials. Consequently, natural antimicrobial rose oil may have beneficial effects on human and environmental health.
Polycystic ovarian syndrome (PCOS) is a polygenic, multifactorial, syndromic disorder with reproductive, endocrine, and metabolic dysfunction seen in reproductive aged women (12-45 years). The exact cause is not known may involve increased luteinizing hormone, increased insulin levels, and a defect in androgen synthesis. The symptoms include anovulation, irregular menses, and hyperandrogenism. It is clinically manifested by hirsutism, acne, and androgenic alopecia. Health care practitioners continue to seek a cure for PCOS as it is increasing in frequency and is one of the major causes of anovulatory infertility.
The case was recorded in the gynaecological department at the Homoeopathic Medical College and Research Centre. An 18- year-old female patient with PCOS was treated with individualised homeopathy (iHOM) medicine between 26th September 2019 and 26th November 2020. During the follow-up visits, treatment outcomes were assessed. To assess whether the changes were due to homoeopathic medicine, an assessment using the modified Naranjo criteria was performed.
Over an observational period of 1 year, beneficial result from iHOM medicine was seen. This treatment method can be used by the physicians in the treatment of PCOS as a complementary health practice.
Considering the multi-factorial aetiology of PCOS, iHOM medicine with lifestyle modification is helpful in treating PCOS.
Considering the multi-factorial aetiology of PCOS, iHOM medicine with lifestyle modification is helpful in treating PCOS.As babies and young children are more vulnerable to respiratory illnesses, pediatric respiratory disorders are a leading cause of death and morbidity. Chronic respiratory illnesses in children include tuberculosis, asthma, bronchopulmonary dysplasia and bronchiectasis. Furthermore, hereditary pulmonary diseases such as primary ciliary dyskinesia and cystic fibrosis are seen in children at a lower rate. Most children are examined by non-professional physicians (eg, senior nursing staff) who are specialized in pediatrics, as nursing practice in outpatient settings grows. Some people have a poor understanding of how to care for ill children. As a result, these professionals must be informed of any risk factors and can identify "red flags" in a sick child quickly so that further care may be escalated properly. Some children will require hospitalization for breathing assistance and additional therapy including antibiotics and hydration. With the growth of "non-medical practitioners" in nursing practice, it is essential to be aware of whether or not to administer antibiotic medication, especially given the risks of antibiotic misuse. EPZ011989 in vitro Nurses are responsible for administering medications and assisting with various therapies, as well as for caring for children and their families during an illness. In specific circumstances, children and parents must be informed about protective and preventative steps that can help reduce the risk for eventual pulmonary disorders, such as vaccinations and smoking cessation.
Traditional Chinese Medicine (TCM) has played a significant role in combating coronavirus disease 2019 (COVID-19) in China. However, our understanding of the efficacy and mechanisms of TCM in treating COVID-19 remains limited. Thus, it is important to stimulate further discussion based on early empirical evidence.
This review aims to summarize initial clinical evidence for the role of TCM in COVID-19 treatment, discuss potential TCM and biological mechanisms, and suggest implications for practice and research.
A literature search was conducted on PubMed, PsycInfo, and Google Scholar between December 2019 and January 2021. Observational studies, retrospective studies, case studies, cohort studies, and randomized controlled trials with at least a published English abstract were inspected and included in the final review.
In general, herbal medicine has been shown to improve clinical symptoms, patient prognosis and mortality, and inflammatory markers, especially when paired with Western medicine. Potentil Chinese Medicine for COVID-19, conclusions cannot be drawn to support its use as a replacement for conventional COVID-19 treatment, given the lack of high-quality evidence from strictly-designed randomized controlled trials. However, there is initial evidence suggesting that TCM may serve as an effective adjunct to conventional treatments in alleviating COVID-19 symptoms. More research is needed to confirm the efficacy and safety of TCM in treating COVID-19.
With the spread of the coronavirus disease (COVID-19), the deterioration of public mental health has become a major global and social problem.
The purpose of this study was to elucidate the relationship between the three mental health problems associated with COVID-19-perceived stress, severe mental distress, and anxiety symptoms-and various demographic factors including occupation.
A nationwide online questionnaire survey was conducted in Japan from August 4 to 31, 2020. In addition to sociodemographic data, the degree of perceived stress, severe mental distress, and anxiety symptoms associated with COVID-19 were measured. After performing a descriptive statistical analysis, factors related to stress, severe mental distress, and anxiety symptoms were analyzed using logistic regression analysis.
A total of 6,547 respondents submitted complete survey responses, among whom 34.9% felt intense stress associated with COVID-19, 17.1% were depressed, and 13.5% had severe anxiety symptoms. The logistic regresic visits, and stress coping mechanisms were associated with mental health during the COVID-19 pandemic, but their associations with stress, severe mental distress, and anxiety symptoms differed. In addition, the actual state of mental health varied according to the respondents' occupation. It is necessary to consider the impact of the COVID-19 pandemic on mental health, not only at the individual level but also at the occupational level.
The Coronavirus Disease-19 (COVID-19) pandemic has radically shifted living practices, influencing changes in the health status and behaviors of everyone.
The aim of this study is to investigate the impact of COVID-19 on self-reported health status and health behaviors, along with any associated factors in a country without stringent lockdown measures.
We conducted an online self-reported survey from November 2020 to December 2020. The study participants were identified through quota sampling by age, sex, and geographical regions among residents aged 19 years or older in Korea. The online survey collected information on basic demographics, changes in self-reported health status and health behaviors during the COVID-19. Self-reported health status and health behaviors were categorized into three groups (unchanged, improved, or worsened). A chi-square test was performed to compare categorical variables, and logistic regression analyses were conducted to identify the factors associated with improving or wo of people. However, in some cases, changes in health status or health behavior were identified. This study highlighted that some groups were overwhelmingly affected by COVID-19 compared to others. Certain groups reported experiencing both worsening and improving health, while other groups reported unchanged health. Age was the most influential factor for change, in particular, young generation's negative health behaviors need more attention in terms of public health. As COVID-19 prolongs, public health interventions for vulnerable groups may be needed.
False claims about COVID-19 vaccines can undermine public trust in ongoing vaccination campaigns, thus posing a threat to global public health. Misinformation originating from various sources has been spreading online since the beginning of the COVID-19 pandemic. Anti-vaccine activists have also begun to utilize platforms like Twitter to promote their views. To properly understand the phenomenon of vaccine hesitancy through the lens of online social media, it is of greatest importance to gather the relevant data.
In this paper, we describe a dataset of Twitter posts and Twitter accounts that publicly exhibit a strong anti-vaccine stance. The dataset is made available to the research community via our AvaxTweets dataset GitHub repository. We characterize the collected accounts in terms of prominent hashtags, shared news sources and most likely political leaning.
We started the ongoing data collection on October 18, 2020, leveraging the Twitter streaming application programming interface (API) to follow a set of specific anti-vaccine related keywords.
