Mcleanlindholm8160

In our study, we aimed to investigate how whole blood viscosity (WBV) affects the development of contrast-induced nephropathy (CIN) in patients undergoing percutaneous coronary intervention (PCI).

In our study, 500 patients who applied to the cardiology clinic and underwent PCI for elective procedure, ST segment elevation myocardial infarction (STEMI), and non-STEMI were prospectively included. Before the procedure, we calculated WBV using the formula [(0.12×hematocrit) + (0.17×(total protein - 2.07)]. We defined CIN as the absolute (≥0.5 mg/dl) or relative increase (≥25%) in serum creatinine 48-72 h after exposure to a contrast agent compared with baseline serum creatinine values.

CIN developed in 69 (13.6%) of the 500 patients in the study. PCI was performed in 206 patients (41.2%) electively, 175 (35%) due to non-STEMI, and 119 (23%) due to STEMI. CIN was observed in 20.2% of the STEMI group, 13.7% of the non-STEMI group, and 10.2% of the elective PCI group. Multivariate logistic regression analysis results show that the independent predictors of CIN are low ejection fraction [OR0.95 (95% CI0.92-0.97); p <0.001], low glomerular filtration rate [OR0.96 (95% CI0.95-0.98); p <0.001], and increased amount of contrast agent [OR1.008 (95% CI1.004-1.01); p <0.001]. When all patients were examined, no significant relationship was found between WBV and CIN. However, in the subgroup evaluation, it was concluded that low WBV was an independent predictor in elective PCI patients [OR0.60 (95% CI0.36-0.99); p=0.04] for CIN.

We found that low WBV was an independent predictor of CIN in patients undergoing elective PCI(NCT04703049).

We found that low WBV was an independent predictor of CIN in patients undergoing elective PCI(NCT04703049).The Clinician-Administered Dissociative States Scale (CADSS) is a structured clinical interview to assess state dissociation rated by clinicians. The current study aimed to validate the German version of CADSS by comparing it to the established self-report measures for dissociation and exploring its underlying factor structure. Severity of within-session state dissociation was assessed directly following a standard psychotherapy session in a trauma-exposed patient sample (N= 105; 81.9% female). Internal consistency, convergent validity with other dissociation measures, and the factorial structure of the instrument were analyzed. The German version exhibited excellent internal consistency (Cronbach's α = .94) and correlated significantly with self-report measures of state dissociation (r = .86) and trait dissociation (r = .77) indicative of high convergent validity. Exploratory factor analysis revealed a three-factor solution with the factors (1) Depersonalization/Derealization, (2) Identity Confusion/Alteration, and (3) Amnesia. Results support the CADSS as a useful instrument to assess state dissociation, conceptualized as a multidimensional construct, in clinical practice.Research attests that when children are given essential knowledge about Child Sexual Abuse (CSA) prevention, such as the maintenance of boundaries and personal space, the correct anatomical names for genitals, and information on how to distinguish between appropriate and inappropriate touching, children are less likely to experience sexual abuse and more likely to disclose abuse they have already encountered. CSA prevention books aim to teach children safety skills, helping to inform them on how to assess a situation and what to do if they are made to feel uncomfortable. This research analyzes 44 CSA prevention books to ascertain whether they are in line with academic recommendations as to what knowledge children should be taught in order to protect them, as much as possible, from sexual abuse. While most of the books do follow advice derived from the academic literature, only 7 books contained 70% or more of the information research determined to be essential. Despite the documented importance of teaching children anatomically correct names for genitals, this was missing in 91% of books analyzed. It is recommended, therefore, in order to ensure sufficient coverage of essential information, that multiple CSA prevention books are obtained for, and read with, children.ObjectivesTo examine the discrepancy between 'told' and screened blood pressure (BP) category, and the association between body composition and told BP category. Methods Between 08/2019-03/2020 college students (n = 1057) were asked what category they had previously been told their BP falls into prior to having their BP and body composition (waist circumference, body mass index (BMI), and body fat percentage) objectively assessed. Results A disproportionate number (>80%) who were told that they had normal BP were categorized as having elevated BP. Men told they had borderline/high BP had less favorable body compositions than those told they had low/normal BP. Less favorable body composition was associated with increased likelihood of men being told that they had borderline/high BP. Conclusions Better BP screening policies and procedures would ensure healthcare providers discuss elevated BP with emerging adults regardless of body composition and avoid missing opportunities to delivery of early and cost-effective interventions.

This study examined whether self-esteem mediates the association between perceived age stigma and emotional well-being (loneliness and emotional isolation) among Korean older adults and how these processes differ by marital status.

Using the 2018 Age Integration and Generation Integration Survey, a cross-sectional national survey of Korean adults, we analyzed data from 266 adults aged 60 and older.

Older adults who perceived greater age stigma reported higher levels of loneliness and emotional isolation. Self-esteem played a significant indirect role in the association between perceived age stigma and the two emotional well-being outcomes. Moderated mediation analyses further revealed significant differences by marital status self-esteem was a more powerful mechanism among unmarried older adults relative to their married counterparts.

The findings suggest that efforts to minimize public and internalized stigmatization of older adults and improve their self-esteem may be critical for their emotional well-being.

The findings suggest that efforts to minimize public and internalized stigmatization of older adults and improve their self-esteem may be critical for their emotional well-being.Objectives The current study investigates the differential coping strategies and mental health consequences of food insecurity in relation to period of the lifespan (middle vs. late adulthood) and household composition (living with vs. without children).Method Using a cross-sectional design, food-related coping strategies, anxiety (GAD-7), and depression (WHO-5) were compared among the following groups middle adults with vs. without children, and middle adults without children vs. late adults without children. Predictive models using hierarchical linear regression examined the main effects of age and household composition with food insecurity predicting mental health; additionally, the interaction of food insecurity with age and household composition was tested in a separate model.Results Middle-adults with and without children share similar frequencies in levels of food insecurity and coping strategies, which were significantly higher than late adults.Conclusion The link between food insecurity and depression was stronger for middle-adults without children than late adults. Food insecurity was a stronger predictor of anxiety for middle-adults with children than those without.Bisphenol A (BPA) is an industrial synthetic chemical that is extensively used for manufacturing polycarbonate plastics and epoxy resins. However, there is limited literature on BPA-induced temporal neurobehavioral transformation and oxidative stress-mediated neurodegeneration in the subtle region of the zebrafish brain. Consequently, an investigational setup was prepared to study the temporal response to duration-dependent BPA exposure on neurobehavioral, oxidative stress, and neurodegeneration in zebrafish. Zebrafish were divided into five groups naïve, control, 7 days (BPA7D), 14 days (BPA14D), and 21 days (BPA21D). Our findings indicated that chronic waterborne exposure to BPA substantially altered the light/dark preference and bottom-dwelling behavior of zebrafish in the BPA14D, and BPA21D groups compared with naïve and control groups. Biochemical studies revealed that there was a significant downregulation in the cellular level of small-molecule antioxidants evidenced by reduced glutathione (GSH) and activity of antioxidant enzymes of glutathione biosynthesis in a duration-dependent manner after exposure to BPA. However, exposure to BPA for 7 days did not induce substantial alteration in biochemical parameters, such as GSH level, protein carbonylation, and superoxide dismutase activity, although the neurobehavioral responses expressively differed from those of the naïve and control groups. Moreover, our histopathological observation also indicated a temporal augmentation in chromatin condensation in the periventricular gray zone (PGZ) of the zebrafish brain after chronic exposure to BPA. The overall outcomes of the present study indicated that the transformed neurobehavioral phenotypes in zebrafish are a consequence of BPA-induced oxidative stress and PGZ neurodegeneration and clearly show a temporal transformation under BPA exposure.

Preterm birth is now a global health problem. There is a great alteration of sleep duration in pregnancy. Whether sleep duration in pregnancy affects preterm birth remains unclarified. This study aimed to examine the associations of sleep duration on preterm birth risk based on the dose-response meta-analysis.

Electronic databases (PubMed, Web of Science, and Ovid) were searched for relevant studies from database inception to September 2020. BTK inhibitor price Studies describing the associations of maternal sleep duration with preterm birth risk were included. A random-effects model was adopted to calculate the summarized relative risk (SRR) and 95% confidence intervals (CIs) as the effect sizes for all studies. Moreover, dose-response analysis was used for combining studies that used categories of sleep duration as exposure. In addition, subgroup analysis and meta-regression analysis were conducted to adjust potential confounders and investigate the source of heterogeneity.

A total of 3771 unique studies were screened, a2).

There is an association of extreme sleep duration in pregnancy with preterm birth. In a non-linear dose-response meta-analysis, a

-shaped relationship between sleep duration and risk of preterm birth was observed and pregnant women who slept 4 h/day had a significantly higher risk of preterm birth than those who slept normally.

There is an association of extreme sleep duration in pregnancy with preterm birth. In a non-linear dose-response meta-analysis, a U-shaped relationship between sleep duration and risk of preterm birth was observed and pregnant women who slept 4 h/day had a significantly higher risk of preterm birth than those who slept normally.