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A carbon-based porous electrode was fabricated by a facile slurry based process using polymethyl methacrylate (PMMA) as a pore-forming agent. It exhibited the reversible reaction of Li into the inner pores of the as-synthesized electrode without dendritic Li growth, which resulted in showing the outstanding cycle performances for lithium metal batteries.This review covers the compound class of one-dimensional gold strings. These compounds feature a formally infinite repetition of gold complexes as monomers/repeating units that are held together by aurophilic interactions, i.e. direct gold-gold contacts. Their molecular structures are primarily determined in the solid state using single crystal X-ray diffraction. selleck products The chemical composition of the employed gold complexes is diverse and furthermore plays a key role in terms of structure characteristics and the resulting properties. One of the most common features of gold strings is their photoluminescence upon UV excitation. The emission energy is often dependent on the distance of adjacent gold ions and the electronic structure of the whole string. In terms of gold strings, these parameters can be fine-tuned by external stimuli such as solvent, pH value, pressure or mechanical stress. This leads to direct structure-property correlations, not only with regard to the photophysical properties, but also electric conductivity for potential application in nanoelectronics. Concerning these correlations, gold strings, consisting of self-assembled individual complexes as building blocks, are the ideal compound class to look at, as perturbations by an inhomogeneity in the ligand sphere (such as the end of a molecule) can be neglected. Therefore, the aim of this review is to shed light on the past achievements and current developments in this area.Non-DNA labels are key components for the construction of functional DNA nanostructures. Here, we present a method to graft covalent labels onto DNA origami nanostructures in an enzymatic one-pot reaction. The DNA methyltransferase M.TaqI labels the DNA nanostructures with azide groups, which serve as universal attachment points via click chemistry. Direct labeling with fluorescent dyes is also demonstrated. The procedure yields structures with high fluorescence intensities and narrow intensity distributions. In combination with UV crosslinking it enables the creation of temperature-stable, intense fluorescent beacons.Lectins, which exhibit viral-interaction abilities, have garnered attention in the current pandemic era as potential neutralizing agents and vaccine candidates. Viral invasion through envelope proteins is modulated by N-linked glycosylation in the spike (S) protein. This study demonstrates the biophysical aspects between lectins and high-mannose and -galactose N-glycans to provide insights into binding events.Correction for 'An ionic liquid-modified RGO/polyaniline composite for high-performance flexible all-solid-state supercapacitors' by Chang Dong et al., Chem. Commun., 2020, DOI 10.1039/d0cc04691d.In this study, antioxidant-rich extracts from brewer's spent grain (BSG) extracted by solid-to-liquid extraction using different solvents water and ethanol and their mixtures at two ratios (80% ethanol  water (v/v) and 60% ethanol  water (v/v)) were characterized. Nutritional composition was evaluated for the extracts and for the solid residues obtained after extraction. Additionally, the extracts were analyzed for the total phenolic content and individual phenolic compounds and related biological properties including antioxidant capacity (ABTS; ORAC and DNA protection), antihypertensive capacity, antibacterial activity and antibiofilm capacity. Safety was also demonstrated through genotoxicity and cytotoxicity tests. The results obtained showed that while all the extracts exhibited high antioxidant capacity (except ethanolic extract), the highest values were obtained for the 60% ethanol  water extract. The identification of phenolic compounds using HPLC showed that catechin and vanillin were the main compounds identified with the highest concentration being obtained for 60% ethanol  water extraction. In the biological activity assays, water and hydroethanolic extracts were multifunctional (antioxidant and antihypertensive capacity, antibacterial and antibiofilm activity), and the 80% ethanol  water presented better results in some assays. All were non-genotoxic, but the cytotoxicity was dependent on the extract concentration, with complete safe application for all up to 1 mg mL-1. Therefore, this study shows the potential of a viable green solvent based and low cost extraction recovery method of bioactive compounds from brewer's spent grain.Anti-angiogenic tyrosine kinase inhibitors (TKIs) have been proved to be effective in prolonging progression-free survival in advanced osteosarcoma. However, osteosarcoma stem-like cells persist for a long time and ultimately cause disease recurrence and therapy resistance. Here, we reveal that inefficient accumulation of Apatinib, an anti-angiogenic TKI, induces the expression of ribosome-associated genes in osteosarcoma, and confers apoptosis resistance. An engineered nanoscale delivery system based on hydrophobic poly(ester amide) has been established to effectively deliver Apatinib to improve the treatment. Notably, the considerable uptake by osteosarcoma cells enables this nanodrug to distribute increasingly inside the tumor. Furthermore, the delivered nano-Apatinib can suppress osteosarcoma stemness and enhance osteosarcoma stem-like cell apoptosis, and overcomes the crucial bottleneck of the unfavorable stem-like cell residue for TKI therapy. Importantly, nano-Apatinib significantly inhibits the osteosarcoma stem-like cell-derived tumor growth in contrast with free Apatinib, with minimal side effects. These results suggest that this Apatinib-loaded nano delivery system may serve as a promising strategy to solve the issue of TKI therapeutic resistance existing in advanced osteosarcoma.The trivalent oxidation state of uranium has been shown to undergo unique reactivity, from its ability to activate a variety of small molecules to its role in the catalytic reduction of ethene to ethane amongst others. Central to this unique reactivity and ability to rationally design ligands for isotope separation is the underlying uranium electronic structure. While electronic structure studies of U(iv), U(v), and U(vi) have been extensive, by comparison, analogous studies of more reduced oxidation states such as U(iii) remains underdeveloped. Herein we report a combined MCD and EPR spectroscopic approach along with density functional theory and multireference wavefunction calculations to elucidate the effects of ligand perturbation in three uranium(iii) Tp* complexes. Overall, the experimental and computational insight suggests that the change in ligand environment across this series of U(iii) complexes resulted in only minor perturbations in the uranium electronic structure. This combined approach was also used to redefine the electronic ground state of a U(iii) complex with a redox non-innocent Bipy- ligand. Overall, these studies demonstrate the efficacy of the combined experimental and theoretical approach towards evaluating electronic structure and bonding in U(iii) complexes and provide important insight into the challenges in altering ligand environments to modify bonding and reactivity in uranium coordination chemistry.Nowadays, the development of Mn4+-activated fluoride phosphors with efficient water and thermal stabilities continues to pose a huge challenge with regard to prolonging the service life and stabilizing the light output for phosphor-converted white light-emitting diodes (pc-WLEDs). Therefore, the synthesis strategy of simple crystal structure optimization is proposed to realize simultaneously the high hydrophobic and thermal stabilities of fluoride phosphors. Herein, Mn4+-doped Na2Si1-yGeyF6 red phosphors are successfully synthesized by a simple coprecipitation method. Satisfactorily, the optimization of Ge4+ and Mn4+ concentrations successfully enhances the luminescence intensity of the original phosphor (Na2SiF6Mn4+) and an obvious red shift can be found. Moreover, the CIE coordinates of red light show that the phosphor has low correlated color temperature and excellent color purity. Based on excitation and emission spectra, the crystal field strength (Dq), Racah parameters (B and C) and nephelauxetic ratio (β1) show that a new Na2Si0.5Ge0.5F6 matrix can meet the high requirements of the crystal field environment when Mn4+ becomes the fluorescence center. Interestingly, the local structure modulation stabilizes the state of existence of Mn4+ in the matrix and enhances the moisture resistance of the phosphor. In addition, the as-prepared Na2Si0.5Ge0.5F6Mn4+ phosphor possesses admirable thermal quenching behavior and color stability at high temperature. More importantly, low correlated color temperature (3408 K), high color rendering index (89.4) and preeminent luminous efficiency (112.89 Im W-1) are achieved using the YAGCe3+-Na2Si0.5Ge0.5F60.06Mn4+ system as color converters for warm pc-WLEDs. The work provides a new insight into the construction of red phosphors with favorable water and thermal stabilities for warm pc-WLEDs.The synthesis of two different types of bis(N,N',N'-substituted 1,2-ethanediamine)s, bridged either through the secondary (type 1) or tertiary (type 2) amine groups is reported. Selected protio-ligands have been applied in subsequent metallation reactions using aluminium, magnesium, tin, and zinc sources allowing to isolate five mononuclear and eight dinuclear complexes. All complexes have been fully characterized and their solid-state structures have been studied by means of single-crystal X-ray diffraction analysis. Nine of the 13 complexes carry reactive alkyl, amide or hydride groups, which indicates their potential as catalysts or supports for (transition) metals.A mild ruthenium(ii)-catalyzed spiroannulation between benzamides and naphthoquinones is developed for the succinct synthesis of biologically relevant spiro-isoindolinone scaffolds. A base promoted transannulation of spirocyclic products en route to valuable benzo[b]phenanthridinetriones in good yields has also been accomplished.Obesity is an increasingly severe global health problem, leading to chronic inflammation and metabolic disorders in both peripheral tissues and the central nervous system. Matcha is a powdered green tea, and it is very popular in recent years as a beverage and food additive. Matcha green tea has been reported to have outstanding potential in regulating obesity-related metabolic syndrome. However, there are few studies on the regulation mechanism of matcha green tea on the central nervous system. In this study, we established a high-fat diet-induced obese mouse model. The results showed that dietary supplementation with matcha could effectively inhibit the weight gain, fat accumulation, glycemia and lipidemia increase, and excessive activation of microglia in the arcuate nucleus of the hypothalamus. Furthermore, we used different concentrations (100%, 80%, 60%, 40%, and 20%, v/v) of ethanol solution to prepare matcha ethanol extracts, and investigated their effects on palmitic acid-induced inflammation of microglial BV-2 cells.