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7° externally rotated to the SEA (range 6.3° internal to 10.3° external). Routinely setting femoral rotation 3° external to the PCA would result in only 51 (51%) TKAs within ±2° of the SEA and 23 (23%) femoral components internally rotated relative to the SEA.

Normal anatomic rotational axes of arthritic knees are highly variable, with a 10° range in the SEA and 16° range in the AP axis. Routinely setting femoral rotation 3° external to the PCA will yield significant error in aligning the femoral component with either the SEA or AP axis.

Normal anatomic rotational axes of arthritic knees are highly variable, with a 10° range in the SEA and 16° range in the AP axis. Routinely setting femoral rotation 3° external to the PCA will yield significant error in aligning the femoral component with either the SEA or AP axis.

Hospital readmission is an important quality-of-care indicator. We sought to examine the rates and predictors of unplanned readmission for the high-risk non-trauma emergency laparotomy patient.

This is a post hoc analysis of a multicenter prospective observational study. Between April 2018 and June 2019, a total of 19 centers enrolled all adult patients undergoing emergency laparotomies and systematically collected preoperative, operative, and 30-day postoperative variables. For the purpose of this study, we defined unplanned readmission as a readmission occurring within 30 days from discharge and one that was immediately preceded by an emergency department visit. Patients were excluded if they died during the index admission, were discharged to hospice, or were transferred to other hospitals. Predictors of unplanned readmission were evaluated using a multivariable logistic regression model, adjusting for patient demographics, comorbidities, laboratory variables, and preoperative acuity of disease variabler emergency laparotomies are common, especially for patients with wound complications or requiring nursing homes. These system factors are potential quality improvement targets to reduce readmissions.

Proinflammatory cytokines play an important role in abdominal surgery and are often associated with the development of postoperative ileus, especially in Crohn's disease. The aim of this study was to investigate proinflammatory cytokine levels in mesenteric fat in Crohn's disease and patients without Crohn's disease.

Human mesenteric tissue specimen were divided into 3 patient groups (n= 10 each) minor surgery (laparoscopic cholecystectomy), major surgery (colectomy) in patients without Crohn's disease, and major surgery (colectomy) in patients with Crohn's disease. Levels of interleukin 6, interleukin 1-β, and tumor necrosis factor α were determined by cytometric bead array, enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction. The Kruskal-Wallis and the Mann-Whitney U test were used to compare continuous variables. For categorical variables, the χ

test or Fisher exact test was used.

In minor surgery, cytokines levels of interleukin 6, interleukin 1-β and Tumor necrost the patients at risk for postoperative ileus.

Proinflammatory cytokines are increased in the mesenteric fat in major operations compared to minor operations, which indicates local mesenteric inflammation. In Crohn's disease, levels of proinflammatory cytokines are even higher, which may put the patients at risk for postoperative ileus.Pyruvate kinase (PK) deficiency is the second most frequent enzymopathy and the most common cause of chronic hereditary non-spherocytic haemolytic anaemia. Its global prevalence is underestimated due to low clinical suspicion of mild cases, associated with difficulties in the performance and interpretation of PK enzymatic activity assays. With the advent of next generation sequencing techniques, a better diagnostic approach is achieved. Treatment remains based on red blood cell transfusions and splenectomy, with special attention to iron overload, not only in transfusion-dependent patients. Nowadays, allogeneic hematopoietic stem cell transplantation is the only curative treatment, recommended only in selected cases of severely affected patients with an HLA-identical donor. Novel pharmacological and gene therapies are in clinical trials, with promising results. In this article, the Spanish Erythropathology Group reviews the current situation of PK deficiency, paying special attention to the usefulness of different diagnostic techniques and to actual and emerging treatments.

To observe the ultrasonographic features of arthritis in patients with primary Sjögren's syndrome (pSS) and to analyze its correlation with clinical manifestations and disease activity.

Ultrasound (US) examinations were performed in a total of 1200 joints of 40 patients with pSS. A semi-quantitative grading method (0-3) for scoring synovial hyperplasia, PD synovitis, bone erosion, tenosynovitis was used. The clinical and laboratory data were collected, disease activity was assessed. The correlation between US lesions and disease activity assessment and clinical manifestations was analyzed.

US findings of musculoskeletal in patients with pSS mainly involved the small joints of the hands and wrists and the lesions were mild. The semi-quantitative score of musculoskeletal US was positively correlated with ESSPRI. The occurrence of musculoskeletal US lesions is associated with immunological abnormalities and inflammatory markers, and patients with high IgG, RF, and inflammatory markers are prone to abnormal US findings.

The incidence of arthritis in patients with pSS is high, and musculoskeletal US has its characteristics. The musculoskeletal US semi-quantitative method can effectively evaluate arthritis in patients with pSS, and the US score of arthritis has a certain correlation with the overall disease activity. US can provide a reference for the diagnosis of arthritis and disease activity assessment in patients with pSS.

The incidence of arthritis in patients with pSS is high, and musculoskeletal US has its characteristics. The musculoskeletal US semi-quantitative method can effectively evaluate arthritis in patients with pSS, and the US score of arthritis has a certain correlation with the overall disease activity. US can provide a reference for the diagnosis of arthritis and disease activity assessment in patients with pSS.

Nonthermal argon plasma (NTAP) has been reported to improve the bond strength of resin cements to yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) ceramics. However, the effect of the inevitable delay before cementation and after treating Y-TZP ceramics with NTAP is unclear.

The purpose of this invitro study was to investigate whether delays of 8, 12, and 24 hours between the Y-TZP ceramic treatment with NTAP and the cementation would affect the surface energy and the bond strength of a self-adhesive resin cement to Y-TZP ceramic.

Sixty plates and 50 blocks of 3Y-TZP ceramic were divided into 2 groups (n=30 and n=25) as-sintered (AS) and airborne-particle abraded with 50-μm Al

O

(APA). These groups were further divided into 5 subgroups (n=6 and n=5) according to the delay between the NTAP treatment and the measurement of surface energy and microtensile bond strength (μTBS) evaluation (0, 8, 12, and 24 hours). For both 3Y-TZP surface conditions (AS and APA), a control group without NTAP treatwas reached after 8 hours (P<.05).

Treatment of 3Y-TZP ceramic with NTAP improved the SE and increased the μTBS of self-adhesive resin cement to 3Y-TZP ceramic. These effects were time dependent, with better results at 8 hours after NTAP treatment.

Treatment of 3Y-TZP ceramic with NTAP improved the SE and increased the μTBS of self-adhesive resin cement to 3Y-TZP ceramic. These effects were time dependent, with better results at 8 hours after NTAP treatment.

The bonding of light-activated adhesives to root canal dentin with an additional touch-polymerization activator has been insufficiently examined.

The purpose of this invitro study was to investigate the effect of touch-polymerization activators and extended light-irradiation time on the microtensile bond strength (μTBS) of light-activated adhesives.

Post cavities were prepared in 50 extracted mandibular premolars and bonded using Prime&Bond Universal (PBU); PBU+Self Cure Activator (SCA); Clearfil SE Bond 2 (SEB); SEB+Clearfil DC Activator (DCA); or Clearfil Universal Bond Quick ER (UBQ). After light-irradiation for 10 or 20 seconds, the post cavities were filled with dual-activated resin core materials. Eight beams were prepared per specimen and subjected to the μTBS test. The μTBS data were analyzed by using 3-way ANOVAs with the Bonferroni correction (α=.05).

The 3-way ANOVAs indicated that the use of touch-polymerization activators (SCA and DCA) significantly increased the μTBS of PBU and SEB in both the coronal (P=.015) and apical (P=.001) regions. The extension of light-irradiation time to 20 seconds significantly improved their μTBS in the apical region (P<.001), but not in the coronal region (P=.09). Light-irradiation for 20 seconds increased the μTBS of UBQ significantly in the coronal region (P=.014).

Touch-polymerization activators improved the bond strength of light-activated adhesives to root canal dentin, especially when combined with an extended light-irradiation time.

Touch-polymerization activators improved the bond strength of light-activated adhesives to root canal dentin, especially when combined with an extended light-irradiation time.

Light transmitted deep into the root canal is an important parameter to increase bonding of the cement to the post and dentin. Glass fiber posts seem to be an option to increase transmitted light, but literature on the light transmittance profile and power transmission to deep canal regions is lacking.

The purpose of this invitro study was to evaluate light delivered by 2 types of fiberglass posts submitted to different surface treatments and to evaluate the bond strength.

Whiteposts and Superposts were allocated to 4 groups no surface treatment, surface treatment with 24% hydrogen peroxide, surface treatment with silane, and surface treatment with 24% hydrogen peroxide plus silane. The total light transmitted by the posts was measured by using an integrating sphere to collect the diffuse light. The light profile that was laterally delivered to the post was measured with a power detector equipped with an optical fiber probe. The bond strength was measured with the push-out test. Scanning electron microsom the cervical to the apical third. Surface treatment impacted bond strength; light transmission through Whiteposts was slightly higher than light transmission through Superposts.

Light transmission and bond strength decreased from the cervical to the apical third. Surface treatment impacted bond strength; light transmission through Whiteposts was slightly higher than light transmission through Superposts.

Understanding how maxillofacial prosthodontists are perceiving changes in head and neck care and the impact of advanced digital technologies on maxillofacial prosthodontics is important. However, no studies could be identified that specifically addressed these subjects.

The purpose of this review of selected literature was to identify issues that guided the development of maxillofacial prosthodontics and the concerns that persist. The review also considered contemporary influences that will affect the future of maxillofacial prosthodontics. The conclusions of the review were used to interpret the results of the exploratory survey reported in Part II.

The review of selected literature was related to the development of maxillofacial prosthodontics in North America between 1950 and 2018. Literature that was considered relevant to the purpose of the review was included.

The review yielded 37 references of interest 34 peer-reviewed publications, 1 guideline, 1 historical publication, and 1 website. Periods in the development of maxillofacial prosthodontics in North America were identified as formation, consolidation, and innovation.

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