Mcgowanlist6269

The production of chestnut (Castanea sativa Miller) is mostly concentrated in Europe. Chestnut is recognized by its high content of antioxidants and phytosterols. This work aimed to evaluate the effects of dietary chestnut consumption over physiological variables of FVB/n mice. Eighteen FVB/n male 7-month-old mice were randomly divided into three experimental groups (n = 6) 1 (control group) fed a standard diet; 2 fed a diet supplemented with 0.55% (w/w) chestnut; and 3 supplemented with 1.1% (w/w) chestnut. Body weight, water, and food intake were recorded weekly. Following 35 days of supplementation, the mice were sacrificed for the collection of biological samples. Chestnut supplementation at 1.1% reduced abdominal adipose tissue. Lower serum cholesterol was also observed in animals supplemented with chestnut. There were no significant differences concerning the incidence of histological lesions nor in biochemical markers of hepatic damage and oxidative stress. These results suggest that chestnut supplementation may contribute to regulate adipose tissue deposition.Although PE-based nanocomposites are gaining interest within the food packaging industry for their outstanding functional properties, their end-of-life has been poorly studied. The lack of identification of such materials suggests that they could end-up in the recycling pathway optimized for the decontamination of un-filled PE. The objective of the present work is to understand and quantify the mechanisms involved in the high temperature desorption of surrogates for PE nanocomposites filled with organo-modified montmorillonite (PNC), compared to conventional PE. An original experimental setup was coupled with a modelling approach to identify the two phenomena involved in the decontamination process diffusion of the surrogate into the bulk and its evaporation at the surface. A sweep of experimental temperatures enabled the determination of diffusion and evaporation parameters for PE and PNC and the activation energies related to the diffusivity among those two materials. The effects of the introduction of clay nanofillers onto the decontamination process have been explained and recommendations for the recycling pathway have been put forward. Influenza A virus (IAV) is a major concern to human health due to the ongoing global threat of a pandemic. Inflammatory and cell death signalling pathways play important roles in host defence against IAV infection. However, severe IAV infections in humans are characterised by excessive inflammation and tissue damage, often leading to fatal disease. While the molecular mechanisms involved in the induction of inflammation during IAV infection have been well studied, the pathways involved in IAV-induced cell death and their impact on immunopathology have not been fully elucidated. There is increasing evidence of significant crosstalk between cell death and inflammatory pathways and a greater understanding of their role in host defence and disease may facilitate the design of new treatments for IAV infection.Tacrolimus is an immunosuppressive drug with a narrow therapeutic index and larger interindividual variability. We identified genetic variants to predict tacrolimus exposure in healthy Korean males using machine learning algorithms such as decision tree, random forest, and least absolute shrinkage and selection operator (LASSO) regression. rs776746 (CYP3A5) and rs1137115 (CYP2A6) are single nucleotide polymorphisms (SNPs) that can affect exposure to tacrolimus. A decision tree, when coupled with random forest analysis, is an efficient tool for predicting the exposure to tacrolimus based on genotype. These tools are helpful to determine an individualized dose of tacrolimus.Due to self-motion and sea waves, moving ships are typically defocused in synthetic aperture radar (SAR) images. To focus non-cooperative targets, the inverse SAR (ISAR) technique is commonly used with motion compensation. The hybrid SAR/ISAR approach allows a long coherent processing interval (CPI), in which SAR targets are processed with ISAR processing, and exploits the advantages of both SAR and ISAR to generate well-focused images of moving targets. TW-37 research buy In this paper, based on hybrid SAR/ISAR processing, we propose an improved rank-one phase estimation method (IROPE). By using an iterative two-step convergence approach in the IROPE, the proposed method achieves accurate phase error, maintains robustness to noise and performs well in estimating various phase errors. The performance of the proposed method is analyzed by comparing it with other focusing algorithms in terms of processing simulated data and real complex image data acquired by Gaofen-3 (GF-3) in spotlight mode. The results demonstrate the effectiveness of the proposed method.Spirochetes can be distinguished from other flagellated bacteria by their long, thin, spiral (or wavy) cell bodies and endoflagella that reside within the periplasmic space, designated as periplasmic flagella (PFs). Some members of the spirochetes are pathogenic, including the causative agents of syphilis, Lyme disease, swine dysentery, and leptospirosis. Furthermore, their unique morphologies have attracted attention of structural biologists; however, the underlying physics of viscoelasticity-dependent spirochetal motility is a longstanding mystery. Elucidating the molecular basis of spirochetal invasion and interaction with hosts, resulting in the appearance of symptoms or the generation of asymptomatic reservoirs, will lead to a deeper understanding of host-pathogen relationships and the development of antimicrobials. Moreover, the mechanism of propulsion in fluids or on surfaces by the rotation of PFs within the narrow periplasmic space could be a designing base for an autonomously driving micro-robot with high efficiency. This review describes diverse morphology and motility observed among the spirochetes and further summarizes the current knowledge on their mechanisms and relations to pathogenicity, mainly from the standpoint of experimental biophysics.Background Borderline resectability in pancreatic cancer (PDAC) is currently debated. Methods Patients undergoing pancreatic resections for PDAC were identified from a prospectively maintained database. As new borderline criteria, the presence of any superior mesenterico-portal vein alteration (SMPV) and perivascular stranding of the superior mesenteric artery (SMA) was evaluated in preoperative imaging. The accuracy of established radiological borderline criteria as compared to the new borderline criteria in predicting R status (sensitivity/negative predictive value) and overall survival was assessed. (3) Results 118 patients undergoing pancreatic resections for PDAC from 2013 to 2018 were identified. Forty-three (36.4%) had radiological perivascular SMA stranding and 55 (46.6%) had SMPV alterations. Interrater reliability was 90% for SMA stranding and 87% for SMPV alterations. The new borderline definition including SMPV alterations and perivascular SMA stranding was the best predictor of conventional R status (p = 0.