Mcgeecrabtree3841

The variations in vitamin C transporter genes may regulate the active transport of vitamin C, and therefore have an impact on cancer risk, but further studies are needed to thoroughly elucidate their involvement in cancer biology.Worldwide, asthma-related healthcare cost remains a major burden. Individuals with severe asthma account for 50% of that cost. Although they are expensive, biologics such as anti-IL5 and anti-IgE agents promise cost-effectiveness when judiciously used to decrease asthma-related hospitalization and the debilitating side effects of systemic corticosteroids. Before considering biologics to treat patients with asthma, current guidelines recommend confirmation of asthma and control of comorbid diseases. Diagnostic confirmation of asthma can be challenging among individuals with severe asthma. In this quality assessment study, we determined the frequency of objective asthma confirmation and addressing of comorbidities prior to starting biologics at a group practice of allergists and immunologists. We surveyed our specialty providers to understand habit(s) leading to the observed results. We identified 40 adult patients who started on biologic modifiers for asthma over the past 5 years. Only 58% of these patients had a proper diagnosis of asthma. Providers underutilized several diagnostic methods that may prove useful in confirming asthma diagnosis in this patient population. The factors contributing to poor asthma control were rarely addressed. A sense of urgency to initiate biologics was the primary reason for the observed results. Further interventions are needed to improve asthma diagnosis and management prior to the initiation of biologic therapeutics.In order to accurately investigate the disturbance of complex distributed mass loading on surface acoustic wave (SAW) propagation characteristics, two-dimensional coupling-of-modes (2-D COM) theory and finite element method (FEM) were used to simulate the responses of SAW sensors. By using the PDE mode of FEM software, four SAW resonators with the loads in different distribution patterns were modeled. Also, we fabricated and measured a series of SAW resonators accordingly. The results showed that the 2-D COM theory combined with the finite element method was able to simulate the transverse modes of the device and the disturbance of the mass loading on the transverse mode effectively, making the simulation more accurate.The main challenge of plant chemical diversity exploration is how to develop tools to study exhaustively plant tissues. Their sustainable sourcing is a limitation as bioguided strategies and dereplication need quite large amounts of plant material. We examine if alternative solutions could overcome these difficulties by obtaining a secure, sustainable, and scalable source of tissues able to biosynthesize an array of metabolites. As this approach would be as independent of the botanical origin as possible, we chose eight plant species from different families. We applied a four steps culture establishment procedure, monitoring targeted compounds through mass spectrometry-based analytical methods. We also characterized the capacities of leaf explants in culture to produce diverse secondary metabolites. In vitro cultures were successfully established for six species with leaf explants still producing a diversity of compounds after the culture establishment procedure. Furthermore, explants from leaves of axenic plantlets were also analyzed. The detection of marker compounds was confirmed after six days in culture for all tested species. Our results show that the first stage of this approach aiming at easing exploration of plant chemodiversity was completed, and leaf tissues could offer an interesting alternative providing a constant source of natural compounds.Blumeria graminis f. sp. hordei (Bgh), the causal agent of barley powdery mildew (PM), is one of the most important barley leaf diseases and is prevalent in most barley growing regions. Infection decreases grain quality and yields on average by 30%. Multi-parent advanced generation inter-cross (MAGIC) populations combine the advantages of bi-parental and association panels and offer the opportunity to incorporate exotic alleles into adapted material. Here, four barley MAGIC populations consisting of six to eight founders were tested for PM resistance in field trials in Denmark. Principle component and STRUCTURE analysis showed the populations were unstructured and genome-wide linkage disequilibrium (LD) decay varied between 14 and 38 Mbp. Genome-wide association studies (GWAS) identified 11 regions associated with PM resistance located on chromosomes 1H, 2H, 3H, 4H, 5H and 7H, of which three regions are putatively novel resistance quantitative trait locus/loci (QTL). For all regions high-confidence candidate genes were identified that are predicted to be involved in pathogen defense. Haplotype analysis of the significant SNPs revealed new allele combinations not present in the founders and associated with high resistance levels.In many industrial fields, there is a need to design and characterize on-line and on-board hydrogen monitoring tools able to operate under extreme conditions. One of these applications is in future nuclear fusion reactors, which will use hydrogen isotopes as a plasma fuel. In this context, the measurement of the concentration of these hydrogen isotopes will be of interest to ensure the correct operating conditions for such reactors. Hydrogen sensors based on solid-state electrolytes will be the first step in the development of new analytical tools able to quantify deuterium and tritium in aggressive environments. In the present work, amperometric hydrogen sensors were constructed and evaluated using two solid-state electrolytes, BaCe0.6Zr0.3Y0.1O3-α and Sr(Ce0.9Zr0.1)0.95Yb0.05O3-α. Prototype sensors were built in order to study their sensitivity in on-line measurements. The experiments were performed in a reactor with a hydrogen-controlled environment. The sensors were evaluated at 500 and 600 °C in amperometric mode by applying 2 and 4 V voltages between electrodes. Both sensors showed increases in sensitivity when the temperature or voltage were increased.Railway track circuit failures can cause significant train delays and economic losses. A crucial point of the railway operation system is the corrective maintenance process. During this operation, the railway lines have the circulation of trains interrupted in the respective sector, where traffic restoration occurs only after completing the maintenance process. Depending on the cause and length of the track circuit, identifying and solving the problem may take a long time. A tool that assists in track circuit fault detection during an inspection adds agility and efficiency in its restoration and cost reduction. This paper presents a new method, based on frequency domain reflectometry, to diagnose and locate false occupancy failures of track circuits. Initially, simulations are performed considering simplified track circuit approximations to demonstrate the operation of the proposed method, where the fault position is estimated by identifying the null points and through non-linear regression on signal amplitude response. A field test is then carried out in a track circuit approximately 1500 m long to validate the proposed method. The results show that the proposed method can identify and estimate the fault location due to a short circuit between rails with high accuracy.The Compressed Sensing (CS) camera can compress images in real time without consuming computing resources. Applying CS theory in the Laser Communication (LC) system can minimize the assumed transmission bandwidth (normally from a satellite to a ground station) and minimize the storage costs of beacon light-spot images; this can save more than ten times the typical bandwidth or storage space. However, the CS compressive process affects the light-spot tracking and key parameters in the images. In this study, we quantitatively explored the feasibility of the CS technique to capture light-spots in LC systems. We redesigned the measurement matrix to adapt to the requirement of light-tracking. We established a succinct structured deep network, the Compressed Sensing Denoising Center Net (CSD-Center Net) for denoising tracking computation from compressed image information. A series of simulations was made to test the performance of information preservation in beacon light spot image storage. With the consideration of CS ratio and application scenarios, coupled with CSD-Center Net and standard centroid, CS can achieve the tracking function well. The information preserved in compressed information correlates with the CS ratio; higher CS ratio can preserve more details. In fact, when the data rate is up than 10%, the accuracy could meet the requirements what we need in most application scenarios.Accurate elevation data, which can be extracted from very high-resolution (VHR) satellite images, are vital for many engineering and land planning applications. In this way, the main goal of this work is to evaluate the capabilities of VHR Deimos-2 panchromatic stereo pairs to obtain digital surface models (DSM) over different land covers (bare soil, urban and agricultural greenhouse areas). As a step prior to extracting the DSM, different orientation models based on refined rational polynomial coefficients (RPC) and a variable number of very accurate ground control points (GCPs) were tested. Entinostat ic50 The best sensor orientation model for Deimos-2 L1B satellite images was the RPC model refined by a first-order polynomial adjustment (RPC1) supported on 12 accurate and evenly spatially distributed GCPs. Regarding the Deimos-2 based DSM, its completeness and vertical accuracy were compared with those obtained from a WorldView-2 panchromatic stereo pair by using exactly the same methodology and semiglobal matching (SGM) algorithm. The Deimos-2 showed worse completeness values (about 6% worse) and vertical accuracy results (RMSEZ 42.4% worse) than those computed from WorldView-2 imagery over the three land covers tested, although only urban areas yielded statistically significant differences (p less then 0.05).This study deals with metalworking fluids (MWFs). According to DIN 51385, depending on their base, the fluids are divided into oil and water fluids. The oil bases include, among others, mineral, synthetic, vegetable and paraffin oils. This division does not comprise surfactant solutions which can be successfully used in metalworking. Due to the fact that this type of fluid was not qualified, a new type of lubricant based on the aqueous solutions of surfactants has been proposed. Two new notions have been introduced surfactant working fluids (SWFs) for working fluids and surfactant lubricants (SLs) for all kinds of lubricants as a broader term. The effect of the physicochemical properties of aqueous solutions of sodium lauroyl sarcosinate (SLS), also known as sodium N-dodecanoyl-N-methyl glycinate, on tribological properties determined using a four-ball machine (Tester T-02) (Łukasiewicz Research Network-The Institute for Sustainable Technologies, Radom, Poland) was analyzed. On the basis of aqueous SLS solutions a composition of working fluids was developed and their functional properties were verified by means of tribological and stand tests as well as during operation.