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Worldwide, it is estimated that millions of individuals suffer from a neurological disorder which can be the result of head injuries, ischaemic events such as a stroke, or neurodegenerative disorders such as Parkinson's disease (PD) and multiple sclerosis (MS). Problems with mobility and hemiparesis are common for these patients, making daily life, social factors and independence heavily affected. Current therapies aimed at improving such conditions are often tedious in nature, with patients often losing vital motivation and positive outlook towards their rehabilitation. The interest in the use of digital technology in neuro-rehabilitation has skyrocketed in the past decade. To gain insight, a systematic review of the literature in the field was conducting following the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) guidelines for three categories stroke, Parkinson's disease and multiple sclerosis. It was found that the majority of the literature (84%) was in favour of the use of digital technologies in the management of neurological dysfunction; with some papers taking a "neutral" or "against" standpoint. It was found that the use of technologies such as virtual reality (VR), robotics, wearable sensors and telehealth was highly accepted by patients, helped to improve function, reduced anxiety and make therapy more accessible to patients living in more remote areas. The most successful therapies were those that used a combination of conventional therapies and new digital technologies.The use of different ways to view the body has always been associated with anatomy. With advancing technology, the use of ultrasound has become more portable and accessible as a way for students to learn anatomy. buy Cordycepin Moreover, ultrasound's direct clinical context makes it an important skill that students need to acquire and be competent in, not only after graduation but on clinical placements as a student. There does appear to be a learned skill in being able to interpret ultrasound images and to be able to relate the anatomy seen to existing anatomical knowledge. In addition, there is a learned skill in being able to correctly hold the ultrasound probe and gain clear images. Because ultrasound use and interpretation is a skill it therefore needs to be taught as part of undergraduate medical and allied health care professional education. A key to successful training is regular teaching sessions distributed longitudinally throughout the curriculum with active, hands-on learning time being the focus of any teaching session.Virtual learning resources (VLRs) developed using immersive technologies like virtual reality are becoming popular in medical education, particularly in anatomy. However, if VLRs are going to be more widely adopted, it is important that they are designed appropriately. The overarching aim of this study was to propose guidelines for the instructional design of VLRs for anatomy education. More specifically, the study grounded these guidelines within cognitive learning theories through an investigation of the cognitive load imposed by VLRs. This included a comparison of stereoscopic and desktop VLR deliveries and an evaluation of the impact of prior knowledge and university experience. Participants were voluntarily recruited to experience stereoscopic and desktop deliveries of a skull anatomy VLR (UNSW Sydney Ethics #HC16592). A MyndBand® electroencephalography (EEG) headset was used to collect brainwave data and theta power was used as an objective cognitive load measure. The National Aeronautics and Space Administration task load index (NASA-TLX) was used to collect perceptions as a subjective measure. Both objective and subjective cognitive load measures were higher overall for the stereoscopic delivery and for participants with prior knowledge, and significantly higher for junior students (P = 0.038). Based on this study's results, those of several of our previous studies and the literature, various factors are important to consider in VLR design. These include delivery modality, their application to collaborative learning, physical fidelity, prior knowledge and prior university experience. Overall, the guidelines proposed based on these factors suggest that VLR design should be learner-centred and aim to reduce extraneous cognitive load.Forensic craniofacial identification encompasses the practices of forensic facial approximation (aka facial reconstruction) and craniofacial superimposition within the field of forensic art in the United States. Training in forensic facial approximation methods historically has used plaster copies, high-cost commercially molded skulls, and photographs. Despite the increased accessibility of computed tomography (CT) and the numerous studies utilizing CT data to better inform facial approximation methods, 3D CT data have not yet been widely used to produce interactive resources or reference catalogs aimed at forensic art practitioner use or method standardization. There are many free, open-source 3D software packages that allow engagement in immersive studies of the relationships between the craniofacial skeleton and facial features and facilitate collaboration between researchers and practitioners. 3D CT software, in particular, allows the bone and soft tissue to be visualized simultaneously with tools such as transparency, clipping, and volume rendering of underlying tissues, allowing for more accurate analyses of bone to soft tissue relationships. Analyses and visualization of 3D CT data can not only facilitate basic research into facial variation and anatomical relationships relevant for reconstructions but can also lead to improved facial reconstruction guidelines. Further, skull and face surface models exported in digital 3D formats allow for 3D printing of custom reference models and novel training materials and modalities for practitioners. This chapter outlines the 3D resources that can be built from CT data for forensic craniofacial identification methods, including how to view 3D craniofacial CT data and modify surface models for 3D printing.Human remains have been displayed in museums in Europe since many centuries for historical, cultural, and educational reasons. link2 Of particular interest are skeletal remains and body parts that have suffered violent deaths and such remains often feature in Criminology Museums. Despite the well-acknowledged value of human remains in medical education, bioarchaeology, and research, the display of human remains still raises ethical considerations ranging in severity depending on the cultural substrate and legal framework of each country. Recent developments in medical imaging and visualisation are offering an alternative way. Taking into account the emerging issues regarding exhibition and handling of human remains, this research project aims to use virtual methods to reconstruct the circumstances of the death of a nineteenth-century outlaw comprising one of the human exhibits at the Criminology Museum of Athens in Greece.For the purpose of the project, the severed head of the outlaw Stavrou was CT scanned, and thesupplementary material to the actual human exhibit for the accurate presentation of Stavrou's history at the Criminology Museum. In addition, it would allow the virtual exhibition of the material for historical and teaching purposes to museums and universities anywhere in Greece and along the globe, thus overcoming the obstacles of moving the actual remains.Facial reconstruction is employed in medical science and archaeology. Though quite popular as anthropological method, it has not so far been used in the orthodox ecclesiastical tradition. This work presents the facial reconstruction of St Eftychios of Crete, who lived between the ninth and tenth centuries. Computed tomography and reverse engineering methods were employed to complete the task. Reconstruction of the mandible and the missing left zygomatic arch was implemented following the Sassouni method. The American method was followed for the soft tissues, with clay deposition of appropriate thickness, on the surface of the skull model. The eyes, nose, and lips were added based on the dimensions of the underlying bone structures. Long hair and beard were added, according to the classic Byzantine tradition pattern of the time period. The final bust developed was then digitized, using a 3D non-contact laser scanner. The 3D geometry produced was employed to produce a mold with vacuum casting techniques. This mold provides the ability to produce copies of the bust, if needed. At the same time, a realistic 3D representation of the Saint's bust was developed, with the aid of special software, in order to compare the traditional forensic reconstruction to the pure digital one. This work is the first case of a Saint's facial reconstruction in the Orthodox Church. The facial reconstruction process, with all the limitations considered, offers the ability to present a realistic aspect of a Greek Orthodox Church Saint, in a form that is easily accessible. Both physical and digital facial reconstruction processes were based on scientific data, so they were as accurate as possible, considering that the mandible was missing in the skull. The facial reconstruction was entirely implemented in Greece creating the basis for similar work in the future. The final bust developed was donated to the Odigitria Monastery, to be exhibited to its visitors.The mesh-to-mesh value comparison (MVC) method developed by Karell et al. (Int J Legal Med 130(5)1315-1322, 2016) facilitates the digital comparison of three-dimensional mesh geometries obtained from laser-scanned or computed tomography data of osteological materials. This method has been employed with great success to pair-matching geometries of intact skeletal antimeres, that is, left and right sides. However, as is frequently the case for archaeological materials, there are few circumstances which proffer complete skeletal remains and fewer still when considering contexts of commingling. Prior to the present research, there existed a paucity of sorting techniques for the diverse taphonomic conditions of skeletal materials found within commingled assemblages, especially regarding fragmentary remains. The present chapter details a study in which the MVC method was adapted to encompass comparisons of isolated components of bone in lieu of entire bone geometries in order to address this dearth. Using post-mortem computed tomography data from 35 individuals, three-dimensional models of 70 mandibular fossae and 69 mandibular condyles were created and then compared using Viewbox 4, to produce numerical mesh-to-mesh values which indicate the geometrical and spatial relationship between any two given models. An all-to-all comparison was used to determine if the MVC method, using an automated Trimmed Iterative Closest Point (TrICP) algorithm, could be utilized to (1) match corresponding bilateral pairs of condyles and fossae and (2) match same-sided articular correlates. The pair-matching of both the condyles and the fossae generally produced high sensitivity and specificity rates. link3 However, the articulation results were much poorer and are not currently recommended.Deregulation of metabolic pathways has increasingly been appreciated as a major driver of cancer in recent years. The principal cancer-associated alterations in metabolism include abnormal uptake of glucose and amino acids and the preferential use of metabolic pathways for the production of biomass and nicotinamide adenine dinucleotide phosphate (NADPH). Aldo-keto reductases (AKRs) are NADPH dependent cytosolic enzymes that can catalyze the reduction of carbonyl groups to primary and secondary alcohols using electrons from NADPH. Aldose reductase, also known as AKR1B1, catalyzes the conversion of excess glucose to sorbitol and has been studied extensively for its role in a number of diabetic pathologies. In recent years, however, high expression of the AKR1B and AKR1C family of enzymes has been strongly associated with worse outcomes in different cancer types. This review provides an overview of the catalysis-dependent and independent data emerging on the molecular mechanisms of the functions of AKRBs in different tumor models with an emphasis of the role of these enzymes in chemoresistance, inflammation, oxidative stress and epithelial-to-mesenchymal transition.