Mcdonaldstokes6552

MAIN OUTCOME MEASURES Composite adverse perinatal outcome, defined as perinatal death, caesarean section for fetal distress or neonatal unit admission. RESULTS Adverse outcomes occurred in 3423 (18%) patients. The model with UA PI alone resulted in an AUC of 0.775 (95% CI 0.709-0.828) and with CPR alone in an AUC of 0.778 (95% CI 0.715-0.831). Addition of CPR to the UA PI model resulted in an increase in the AUC of 0.003 points (0.778, 95% CI 0.714-0.831). These results were consistent across all subgroups. CONCLUSIONS CPR added no predictive value for adverse perinatal outcome beyond UA PI, when assessing singleton pregnancies, irrespective of gestational age or fetal size. This article is protected by copyright. All rights reserved.Solid residues such as primary sludge (PS), waste activated sludge (WAS) and food waste (FW) can be stabilized through anaerobic digestion (AD). Application of the thermal hydrolysis process (THP) prior to AD results in several benefits in AD and dewatering. However, soluble recalcitrant compounds associated with Maillard reactions have been identified after THP which can impact downstream processes and water discharge limits. In this study, the soluble colloidal chemical oxygen demand, color, ultraviolet absorbance at 254 nm and dissolved organic nitrogen in seven full-scale THP facilities were quantified and compared. The THP substrate influenced the concentration of soluble melanoidin-associated compounds in the digestates. THP implementation in five water resource recovery facilities (WRRFs) was modelled and found to give a 3-8 mg/L increase on the water effluent COD concentration depending on the PS/WAS ratio. The results provide novel information useful in planning new WRRFs and optimization of existing facilities. This article is protected by copyright. All rights reserved.Regulating the coordination environment of atomically dispersed catalysts is vital for catalytic reaction but still remains a challenge. Herein, an ionic exchange strategy is developed to fabricate atomically dispersed copper (Cu) catalysts with controllable coordination structure. In this process, the adsorbed Cu ions exchange with Zn nodes in ZIF-8 under high temperature, resulting in the trapping of Cu atoms within the cavities of the metal-organic framework, and thus forming Cu single-atom catalysts. More importantly, altering pyrolysis temperature can effectively control the structure of active metal center at atomic level. Specifically, higher treatment temperature (900 °C) leads to unsaturated Cu-nitrogen architecture (CuN3 moieties) in atomically dispersed Cu catalysts. Electrochemical test indicates atomically dispersed Cu catalysts with CuN3 moieties possess superior oxygen reduction reaction performance than that with higher Cu-nitrogen coordination number (CuN4 moieties), with a higher half-wave potential of 180 mV and the 10 times turnover frequency than that of CuN4 . Density functional theory calculation analysis further shows that the low N coordination number of Cu single-atom catalysts (CuN3 ) is favorable for the formation of O2 * intermediate, and thus boosts the oxygen reduction reaction. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Uterine ruptures typically occur suddenly, have obvious symptoms, and may require urgent treatment. We experienced a case of complete rupture of an unscarred uterus that was undetected for 9 days. We report the clinical course and possible factors that led to it. Nine days after delivery, complete rupture of the posterior uterine wall was diagnosed by magnetic resonance imaging. The colon and ovaries were tightly adhered to the posterior uterine body. When this adhesive lesion was detached, 7 cm horizontal defects of the muscular layer were revealed. The ruptured wound was repaired. Magnetic resonance imaging 1 year postoperatively showed no thinning of the repaired lesion and suggested successful reperfusion. Mild clinical course despite complete uterine rupture was presumably because of adhesion of the ovaries and intestines to the rupture site. © 2020 Japan Society of Obstetrics and Gynecology.The aim of this work was to explore whether bisoprolol plays a protective role in cardiomyocytes against ischemia reperfusion injury via PI3K/AKT/ GSK3β pathway. We pretreated male Sprague-Dawley (SD) rats with bisoprolol by oral administration prior to 0.5 h ischemia/4 h reperfusion. Myocardial infarct size and serum levels of cTnI and CK-MB were measured. In vitro, H9c2 cells were treated with hypoxia and reoxygenation, followed by measurement of cell viability, apoptosis, ROS production, cytometry, activities of AKT, GSK3β and p-38 in the presence and absence of GSK3β siRNA. We found that bisoprolol reduced infarct size from 44% in I/R group to 31% in treated group (P less then 0.05). The levels of cTnI and CK-MB were dereased from 286±7 pg/ml and 32.2±2 ng/ml in I/R group to 196±2 pg/ml and 19.6±0.9 ng/ml in the treated group, respectively (P less then 0.05). Bisoprolol also increased cell viability while decreased apoptosis and ROS production in the treatment of hypoxia/ reoxygenation. Furthermore, bisoprolol increased AKT and GSK3β phosphorylation, an effect that was immediately eliminated by LY294002. GSK3β-specific siRNA experiment further confirmed that bisoprolol protected the myocardium against hypoxia/reoxygention-induced injury via suppressing GSK3β activity. In conclusion, bisoprolol protected myocardium against ischemia-reperfusion injury via the PI3K/AKT/ GSK3β pathway. This article is protected by copyright. All rights reserved.Macrophages are motile cells that roam the extracellular spaces within organs or the body cavity and carry out essential functions in organ development and immunity. New work published in The EMBO Journal adds surprising new insights into the heterogeneity of Drosophila macrophages revealing many similarities to their vertebrate counterparts. © 2020 The Author.OBJECTIVE The recommendation for conventional body weight loss (BWL) treatment in obesity is 5-10%. It is not clear whether BWL is similar across the three different body mass index (BMI) obesity classes. The aim was to provide an overview on BWL across these classes in moderate lifestyle/diet intervention programs. METHOD A systematic literature search was conducted and the evidence of randomized controlled trials (RCTs) and pre-post design studies synthesized. The outcome was BWL. learn more RESULTS For RCTs, mean BWL in the intervention group was 3.6 kg (class I) and 5.3 kg (class II), which equates to 4 and 5% BWL, respectively. None of the assessed class III obesity studies met the inclusion criteria. For pre-post design studies, mean BWL was 5.4 kg (class I), 5.5 kg (class II) and 7.9 kg (class III), with high variation within and across studies in the latter. This equates to 6, 5 and, 6% BWL, respectively. CONCLUSIONS BWL of moderate BWL programs are similar across the different obesity classes. For class I obesity, the results differ between RCT and pre-post design studies by 2% BWL.