Mccrackenolsson9885

The proposed platform may facilitate the development of this neuroimaging modality in any setting where dedicated hardware is not available or in clinical scanners.Automatically recognising surgical gestures from surgical data is an important building block of automated activity recognition and analytics, technical skill assessment, intra-operative assistance and eventually robotic automation. The complexity of articulated instrument trajectories and the inherent variability due to surgical style and patient anatomy make analysis and fine-grained segmentation of surgical motion patterns from robot kinematics alone very difficult. Surgical video provides crucial information from the surgical site with context for the kinematic data and the interaction between the instruments and tissue. Yet sensor fusion between the robot data and surgical video stream is non-trivial because the data have different frequency, dimensions and discriminative capability. In this paper, we integrate multimodal attention mechanisms in a two-stream temporal convolutional network to compute relevance scores and weight kinematic and visual feature representations dynamically in time, aiming to aid multimodal network training and achieve effective sensor fusion. We report the results of our system on the JIGSAWS benchmark dataset and on a new in vivo dataset of suturing segments from robotic prostatectomy procedures. Our results are promising and obtain multimodal prediction sequences with higher accuracy and better temporal structure than corresponding unimodal solutions. Visualization of attention scores also gives physically interpretable insights on network understanding of strengths and weaknesses of each sensor.In the above article [1], in the second paragraph of Section II-A, the randomly selected low-pitch audio cue was 1.5 kHz (not 4 kHz). Thus, the article should state "the two-lever-press discrimination task trials were initialized by a high-pitch (10 kHz) or low-pitch (1.5 kHz) audio cue, which was randomly generated."In the above article [1], the following Acknowledgment is added The authors would like to thank Ethan Firestone for his assistance in data analysis and preparation of Figure 7 in the article.Manual gestures and speech recruit a common neural network, involving Broca's area in the left hemisphere. Such speech-gesture integration gave rise to theories on the critical role of manual gesturing in the origin of language. Within this evolutionary framework, research on gestural communication in our closer primate relatives has received renewed attention for investigating its potential language-like features. Here, using in vivo anatomical MRI in 50 baboons, we found that communicative gesturing is related to Broca homologue's marker in monkeys, namely the ventral portion of the Inferior Arcuate sulcus (IA sulcus). In fact, both direction and degree of gestural communication's handedness - but not handedness for object manipulation are associated and correlated with contralateral depth asymmetry at this exact IA sulcus portion. In other words, baboons that prefer to communicate with their right hand have a deeper left-than-right IA sulcus, than those preferring to communicate with their left hand and vice versa. Interestingly, in contrast to handedness for object manipulation, gestural communication's lateralisation is not associated to the Central sulcus depth asymmetry, suggesting a double dissociation of handedness' types between manipulative action and gestural communication. It is thus not excluded that this specific gestural lateralisation signature within the baboons' frontal cortex might reflect a phylogenetical continuity with language-related Broca lateralisation in humans.RNA-catalyzed RNA replication is widely considered a key step in the emergence of life's first genetic system. However, RNA replication can be impeded by the extraordinary stability of duplex RNA products, which must be dissociated for re-initiation of the next replication cycle. Here, we have explored rolling circle synthesis (RCS) as a potential solution to this strand separation problem. We observe sustained RCS by a triplet polymerase ribozyme beyond full-length circle synthesis with strand displacement yielding concatemeric RNA products. Furthermore, we show RCS of a circular Hammerhead ribozyme capable of self-cleavage and re-circularization. Thus, all steps of a viroid-like RNA replication pathway can be catalyzed by RNA alone. Finally, we explore potential RCS mechanisms by molecular dynamics simulations, which indicate a progressive build-up of conformational strain upon RCS with destabilization of nascent strand 5'- and 3'-ends. Our results have implications for the emergence of RNA replication and for understanding the potential of RNA to support complex genetic processes.Engineered Genetic Incompatibility (EGI) is a method to create species-like barriers to sexual reproduction. It has applications in pest control that mimic Sterile Insect Technique when only EGI males are released. This can be facilitated by introducing conditional female-lethality to EGI strains to generate a sex-sorting incompatible male system (SSIMS). Here, we demonstrate a proof of concept by combining tetracycline-controlled female lethality constructs with a pyramus-targeting EGI line in the model insect Drosophila melanogaster. We show that both functions (incompatibility and sex-sorting) are robustly maintained in the SSIMS line and that this approach is effective for population suppression in cage experiments. Further we show that SSIMS males remain competitive with wild-type males for reproduction with wild-type females, including at the level of sperm competition.Wound breakdown following a total joint arthroplasty is a difficult problem to manage. Early aggressive debridement and closure is essential to prevent a subsequent prosthetic joint infection. Open management of a wound that communicates directly with the joint in the form of wet to dry dressings, iodoform packings, or a non-incisional wound vac should be avoided. Such treatment is inappropriate and leads to difficult to treat multi-organism infections and less than optimal results. (Journal of Surgical Orthopaedic Advances 30(4)263-264, 2021).Intravenous antibiotic therapy remains necessary for many patients with prosthetic joint infections. Intravenous therapies may be used for short durations before switching to oral regimens or may be used for the entirety of therapy. Factors to consider in intravenous antibiotic selection include pathogen factors such as resistance profiles, host factors such as allergies, and drug factors including how difficult the selected agent would be to administer in the outpatient setting. Monitoring of prolonged intravenous therapy in the outpatient setting requires weekly monitoring of labs with specific labs required to monitor certain antibiotics. This narrative review assesses the appropriate duration, antimicrobial selection by pathogen, and monitoring parameters for intravenous antibiotic treatment of prosthetic joint infections. (Journal of Surgical Orthopaedic Advances 30(4)256-262, 2021).When faced with the necessity of surgery in a previously operated knee, pre-operative planning and understanding of the vascular anatomy to the front of the knee is essential. Blood flow to the anterior aspect of the knee comes from medial to lateral. Therefore, in the case of multiple previous knee incisions the most lateral incision should always be chosen to avoid skin necrosis. The concept of a safe distance between incisions is inappropriate, risks extensive skin necrosis, and should be abandoned. (Journal of Surgical Orthopaedic Advances 30(4)253-255, 2021).Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty. We reviewed the current data on DAIR procedures and two-stage exchange for periprosthetic knee infection. This case study illustrates successful treatment of an acute PJI using a debridement and implant retention (DAIR) technique with adjuvant intraosseous (IO) vancomycin. (Journal of Surgical Orthopaedic Advances 30(4)249-252, 2021).Intravenous antibiotic therapy remains necessary for many patients with prosthetic joint infections. Intravenous therapies may be used for short durations before switching to oral regimens or may be used for the entirety of therapy. Factors to consider intravenous antibiotic selection include pathogen factors such as resistance profiles, host factors such as allergies, and drug factors including how difficult the selected agent would be to administer in the outpatient setting. Monitoring of prolonged intravenous therapy in the outpatient setting requires weekly monitoring of labs with specific labs required to monitor certain antibiotics. This narrative review assesses the appropriate duration, antimicrobial selection by pathogen, and monitoring parameters for intravenous antibiotic treatment of prosthetic joint infections. (Journal of Surgical Orthopaedic Advances 30(4)243-248, 2021).Removal of well-fixed total hip arthroplasty components is a fundamental necessity to cure chronic prosthetic hip joint infection. However, the benefits of infection eradication must be weighed against the potential morbidity associated with implant removal. Preoperative identification of implant type, knowledge of its design characteristics, availability of specialized instrumentation and knowledge of specific surgical techniques are key elements of success. With proper preoperative planning and surgical technique, removal of well-fixed total hip arthroplasty components can be accomplished safely and can provide improvements in quality of life for patients suffering from the symptoms associated with prosthetic hip joint infection. (Journal of Surgical Orthopaedic Advances 30(4)235-242, 2021).Periprosthetic joint infection after knee arthroplasty is exceptionally challenging to manage and can result in significant morbidity and mortality for the patient. When irrigation and debridement, polyethylene exchange, and one- or two-stage exchange fail to clear the infection, the surgeon is left with two primary salvage therapies knee arthrodesis and amputation. The decision between these two treatments is difficult and requires an open conversation with the patient about their desire and expectations. The purpose of this review article is to give an overview of knee arthrodesis and amputation after periprosthetic joint infection about the knee as well as provide two case examples to highlight these two management strategies. (Journal of Surgical Orthopaedic Advances 30(4)231-234, 2021).Prosthetic joint infections (PJI) are devastating complications. Antiseptic irrigation fluids have shown promising in vitro results in eradicating planktonic bacteria and decreasing biofilm burden. Topical antibiotics, specifically vancomycin, represents another potentially cost-effective way to prevent acute postoperative PJI. We provide a review of the current literature and recommendations on these measures. Overall, a current lack of high-powered, prospective studies exists to definitively support the use of any specific antiseptic solution or topical antibiotic in primary or revision total joint arthroplasty. Some studies support the use of dilute povidone-iodine lavage when combined with vancomycin powder. Data also exists to support the cost effectiveness of povidone-iodine, with the necessary risk reduction to justify its cost. Cefodizime Contradictory evidence exists demonstrating no differences in PJI rates with these measures and possibly higher rates of aseptic wound complications associated with vancomycin power.