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Cancer cells are confronted with nutrient deprivation because of high proliferation rate especially at the early stage of their development. There is a frequent assumption that nutrient deprivation decreases the basal activity of cancer cells. Contrarily, there are recent evidence suggesting that cancer cells are able to modulate signaling pathways to adapt with new condition and continue their survival. HDM201 molecular weight This property of cancer cells is believed to be one of the prerequisites for cancer progression and chemoresistance. Moreover, recent experiments show that serum starvation in vitro as a mimic situation of nutrient deprivation in vivo triggers different signaling pathways leading to changes in cancer cell behavior, which may interfere with experimental results. Considering these facts, the better understanding of the effect of nutrient deprivation on cancer cell behavior will help us to give more accurate conclusions regarding results of in vitro studies and also to develop new strategies to treat different cancers in vivo. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Atopic dermatitis (AD) is a chronic inflammatory skin disease. Patients with AD have increased infection risk, including skin infections and systemic infections. Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin-4 (IL-4) and IL-13. Dupilumab is approved for inadequately controlled moderate-to-severe AD.1. This article is protected by copyright. All rights reserved.AIM To analyze socio-demographic and labor correlates of labor precariousness among Mexican nurses 2005-2018. BACKGROUND The progressive loss of labor rights has led to a situation characterized by precarious working conditions among health workers globally. METHODS A repeated cross-sectional and population-based study was carried out (N=3 699 282). A generalized ordinal logistic regression model was estimated to assess correlates of precariousness. Precariousness was defined as a non-weighted score of the sum of five dichotomous variables i) non-written contract; ii) income lower than two times the minimum wage; iii) with a partial or an extended workday; iv) without social benefits; and v) without social security. RESULTS The labor precariousness level increased during the studied period, particularly among the younger and the older, the single ones and among those located in sub-urban and rural areas. Nurses with lower levels of training were more exposed to precarious conditions as well as those with jobs in private health institutions or working outside the health sector. CONCLUSIONS Precarious work is considered a combination of global and local labor factors, including the lack of protective labor policies in health institutions, which calls for the development of a public policy to protect jobs in the health sector. This article is protected by copyright. All rights reserved.Diels-Alder cycloaddition of various dienophiles to PAHs bay region is particularly effective and useful tool for PAHs structure and finally properties modification. It is due to the fact that Diels-Alder cycloaddition belongs to single-step Annulative π-Extension (APEX) reactions and represents the maximum in synthetic efficiency for the constructions of π-extended PAHs including functionalised ones, nanographenes, and π-extended fused heteroarenes. Herein we report new applications of APEX strategy for the synthesis of derivatives of 1,2-diarylbenzo[ghi]perylene, 1,2-diarylbenzo[ghi]perylenebisimide and 1,2-disubstituted-benzo[j]coronene. Namely, so far unknown cycloaddition of 1,2-diarylacetylenes into perylene and perylenebisimides bay region was used. 1,2-Disubstituted-benzo[j]coronenes were obtained via cycloaddition of benzyne into 1,2-diarylbenzo[ghi]perylenes using a new highly effective system for benzyne generation and/or high pressure conditions. Moreover, we report unprecedented Diels-Alder cycloaddition-cycloaromatisation domino-type reaction between 1,4-(9,9-dialkylfluoren-3-yl)-1,3-butadiynes and perylene. The obtained diaryl-substituted-core-extended PAHs were characterized by DFT calculation, electrochemical and spectroscopic measurements. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.OBJECTIVE Posttraumatic stress disorder (PTSD) symptoms (PTSS) are common after minor injuries and can impair recovery. We sought to understand whether an evidence-based mobile phone application with self-help tools (PTSD Coach) could be useful to improve recovery after acute trauma among injured emergency department (ED) patients. This pilot study examined the feasibility, acceptability and potential benefit of using PTSD Coach among acutely injured motor-vehicle crash (MVC) patients. METHODS From September 2017-September 2018, we recruited adult patients within 24 hours post-MVC from the EDs of two Level 1 trauma centers in the United States. We randomly assigned 64 injured adults to either the PTSD Coach (n = 33) or treatment as usual (TAU; n = 31) condition. We assessed PTSD symptoms (PTSS) and associated symptoms at 1-month (83% retained) and 3-months (73% retained) post-enrollment. RESULTS Enrollment was feasible (74% of eligible subjects participated) but usability and engagement were low (67% used PTSreserved.PRCC-TFE3 translocation renal cell carcinomas (tRCC) is a common subtype of TFE3 tRCCs in which TFE3 fusions are indicated as oncogenes to promote tumor development. PRCC-TFE3 fusions are often accumulated in the nucleus and related to poorer outcomes and higher stages (III/IV). In this study, we found that PRCC-TFE3 could positively regulate expression of both dynamin-related protein 1 (Drp1) and fission protein 1, and alter distribution of mitochondria, which could promote cell migration and invasion independent of matrix metalloproteinase-2 (MMP-2) and MMP-9. Together, our findings showed a new mechanism for PRCC-TFE3 tRCC cell migration and invasion by alteration of mitochondrial dynamics. Thus, targeting dysregulated Drp1-dependent mitochondrial fission may provide a novel strategy for suppressing the progression of PRCC-TFE3 tRCC. © 2020 International Federation for Cell Biology.