Mccartyhildebrandt3413

In addition, the evaluation of histopathological and immunohistochemical PCNA expression showed significant variations in the liver that confirm the biochemical results. Administration of REO pre- or post-chromium treatment restored the parameters cited above near to the normal values. Otherwise, individual intake with REO slumped lipid peroxidation and gotten better antioxidant status significantly. Conclusively, REO proved to be an effective antioxidant in modulating Cr VI-induced hepatotoxicity, especially in the pretreated rats.The acceptance of combined pre-composting and vermicomposting systems is increasing because of the advantage in rapidly stabilizing organic wastes and reducing emission of greenhouse gasses (GHG). However, GHG emission during the pre-composting phase is often neglected when evaluating the system. This study aimed to quantify GHG emission from a combined pre-composting and vermicomposting system and to investigate the effects of earthworms on GHG emission. A combined system using Eisenia fetida was employed to stabilize maize stover and cow dung (mixing ratio 6040). The inoculating densities were 60 (T1), 120 (T2), and 180 (T3) earthworms per kilogram of substrate. A traditional composting system without earthworms was set as a control (T0). The results indicated that earthworms increased CO2 while decreased CH4 and N2O emissions compared to the control. Higher emission of CO2 suggested that the earthworms promoted the degradation of the substrates. Lower emission of CH4 and N2O showed the advantage of the combined system because CH4 and N2O possess extremely higher global warming potential than that of CO2. T2 is recommended for stabilizing maize stover and cow dung when making a tradeoff between stabilization rate and reduction of GHG. The percentages of GHG emission during pre-composting relative to total GHG emission in T1, T2, and T3 were 34%, 35%, and 30%, respectively. GHG emission is non-negligible when using a combined system, especially the emission of GHG during the pre-composting phase cannot be ignored.The natural abundance of Cr and Ni in serpentine soils is well-known, but the food safety of rice grown in these hazardous paddy soils is poorly understood. The study evaluated the bioaccumulation of chromium (Cr) and nickel (Ni) in rice (Oryza sativa) grown in serpentine-derived paddy soils in the Philippines. Surface soil (0-20 cm) samples were collected and characterized across three (i.e., Masinloc, Candelaria, and Sta. Cruz) paddy areas in Luzon Island, Philippines. At least 3 to 4 whole rice plants at mature stage were uprooted manually in each sampling point where the soil samples were collected. The total Cr and Ni concentrations in rice (i.e., roots, shoots, and grains) and soil, soil physicochemical properties, bioaccumulation factor (BAF), translocation factor (TF), and the hazard quotients (HQ) were determined. Results revealed that Cr and Ni in rice were accumulated mostly in the roots. Although paddy soils had elevated total Cr and Ni concentrations, the BAF and soil-to-root TF values for Cr and Ni were less then 1. In terms of human health risks, results further revealed low risk for both male and female Filipino adults as HQ values for Cr and Ni were less then 1. While it is safe to consume rice grown in the area in terms of Cr and Ni dietary intake, more studies are necessary to understand the dynamics and bioavailability of these heavy metals in other crops and drinking water from tube wells in these areas in order to provide a more holistic human health-based assessments and to ensure consumer safety in serpentine areas. In addition, a more reliable data on Cr and Ni speciation in serpentine soils and crops is critically important. Further studies are also needed to understand the contribution of bioavailable heavy metals in improving the soil health to achieve food safety.Airway hyperresponsiveness (AHR) is characterized by excessive bronchoconstriction in response to nonspecific stimuli, thereby leading to airway stenosis and increased airway resistance. AHR is recognized as a key characteristic of asthma and is associated with significant morbidity. At present, many studies on the molecular mechanisms of AHR have mainly focused on the imbalance in Th1/Th2 cell function and the abnormal contraction of airway smooth muscle cells. However, the specific mechanisms of AHR remain unclear and need to be systematically elaborated. In addition, the effect of air pollution on the respiratory system has become a worldwide concern. To date, numerous studies have indicated that certain concentrations of fine particulate matter (PM2.5) can increase airway responsiveness and induce acute exacerbation of asthma. Of note, the concentration of PM2.5 does correlate with the degree of AHR. Numerous studies exploring the toxicity of PM2.5 have mainly focused on the inflammatory response, oxidative stress, genotoxicity, apoptosis, autophagy, and so on. However, there have been few reviews systematically elaborating the molecular mechanisms by which PM2.5 induces AHR. selleck products The present review separately sheds light on the underlying molecular mechanisms of AHR and PM2.5-induced AHR.Pollution is a global concern, increasing rapidly throughout marine and terrestrial ecosystems, and affecting many species. Urbanization enhances waste production, leading to the opening of landfills that constitute a spatially and temporally predictable food source for opportunistic species. Several species of gulls are known to exploit and breed in urban areas, taking advantage of accessible and diverse food resources. The exploitation of anthropogenic food subsidies at sea (e.g. fishery discards), urban sites, and landfills leads to debris ingestion by gulls with potential negative effects. Here we characterize anthropogenic debris ingested by yellow-legged gulls (Larus michahellis) along Portugal, by analysing the content of pellets collected in (1) natural and urban breeding locations, and in (2) urban and landfill resting sites, to assess seasonal patterns in the ingestion of anthropogenic debris. We also relate diet with the presence of anthropogenic debris. Debris materials were found in 28.8% of pellets from breeding locations (natural and urban) and in 89.