Mayooneill3211

Women with pregnancies complicated by IUGR are at increased risk for future cardiovascular disease. Nevertheless, it is unknown whether endothelial function of women with pregnancies complicated by IUGR is already impaired during pregnancy. Hence, we evaluated maternal endothelial function in pregnancies complicated by IUGR due to placental dysfunction.

Prospective cohort study assessing systemic endothelial function of women with singleton pregnancies and estimated fetal weight (EFW) below 10th percentile and abnormal umbilical artery flow (n=15). Control group included women with singleton pregnancies and normal EFW (n=22). Endothelial function was assessed using EndoPAT™ device which evaluates the change in peripheral vascular tone in reaction to temporal ischemia, a process called reactive hyperemia. The ratio of the readings before and after ischemia is used to assess endothelial function and called reactive hyperemia index (RHI). Aloxistatin Low RHI values indicate endothelial dysfunction.

The median gestational age at endoPAT examination was comparable between the IUGR and control groups (32; IQR 31,33; p=0.18). The median RHI was significantly lower in the IUGR group compared to the control group (1.3 vs 1.5, p=0.02). Median gestational age at delivery and mean neonatal birth weight were lower in the IUGR group compared to the control group (36.7 (35.6,37.2) vs 37.7 (35.3, 39.3), p=0.04 and 1647±414g vs 2785±587g, p<0.001).

Pregnant women with IUGR due to placental dysfunction are characterized by impaired systemic endothelial function.

Pregnant women with IUGR due to placental dysfunction are characterized by impaired systemic endothelial function.Recent advances in the processing of wear-resistant calcium-phosphate reinforced CoCrMo composites for articulating surface applications has necessitated further investigation of performance in biological conditions relevant to patient applications. To this end, CoCrMo composites containing calcium phosphate in the form of hydroxyapatite (HA) were manufactured to study the influence of the reinforcing phase on the tribofilm formation in biologically-relevant conditions. The CoCrMo-HA composites were processed using a laser engineered net shaping (LENS™) additive manufacturing (AM) system with three distinctive compositions CoCrMo-0%HA, CoCrMo-1%HA, and CoCrMo-3%HA. Extensive wear testing of the CoCrMo-HA composites was carried out in DMEM (cell media) and DMEM + Hyaluronic acid (found naturally in synovial fluid). Wear tests were performed at loads ranging from 5N to 20N, and wear media was measured post-test using ICP-MS techniques to release Co and Cr ions. During testing, all coefficients of friction remained in the 0.15-0.25 range, which was lower than the previously reported 0.50-0.75 range in DI water, indicating that the DMEM + hyaluronic acid media plays a significant role in reducing frictional contact. At loads higher than 15N, the HA-tribofilm exhibited a breakdown resulting in higher wear rates but still lower overall ion release than the CoCrMo control composition. Our results indicate that CoCrMo alloys with HA addition can significantly reduce wear rates and ion release even in the presence of naturally-occurring synovial-fluid friction-reducing media.Poly-ether-ether-ketone (PEEK) possesses excellent biocompatibility and similar elastic modulus as bones but yet suffers from poor osseointegration. In order to balance PEEK's mechanical and osseointegration properties, a novel surface porous PEEK (SP-PEEK) is successfully fabricated by fused deposition modelling three-dimensional printing (FDM 3DP) and characterized by mechanical and osteogenesis in vitro tests. Moreover, the effects of pore diameter and pore layer number on the mechanical behaviors of SP-PEEK are investigated by theoretical model and numerical simulation. Comparison among experimental, theoretical and simulation results show good agreement. As pore diameter decreases, the equivalent strength and modulus become more sensitive to the decrease of pore layer number. In addition, the SP-PEEK exhibits the mechanical properties within the range of human trabecular bone and cortical bone, and thus can be tailored to mimic human bone by adjusting the pore diameter and pore layer number, which is benefit to mitigate stress shielding. The effects of pore diameter on the cell proliferation and osteogenic differentiation of SP-PEEK are tested by the co-culture of osteoblast precursor cells (MC3T3-E1) and SP-PEEK round discs. Results showcase that porous surface improves the osteogenesis in vitro, and the SP-PEEK group that the pore diameter is 0.6 mm exhibits optimal-performance osteogenesis in vitro.In this research, a dual-randomness bi-level interval multi-objective programming (DR-BIMP) model was developed for supporting water resources management among multiple water sectors under complexities and uncertainties. Techniques of bi-level multi-objective programming (BMOP), double-sided stochastic chance-constrained programming (DSCCP), and interval parameter programming (IPP) were incorporated into an integrated modeling framework to achieve comprehensive consideration of the complexities and uncertainties of water resources management systems. The DR-BIMP model can not only effectively deal with the interactive effects between multiple decision-makers in complex water management systems through the bi-level hierarchical strategies, but also can characterize the multiple uncertainties information expressed as interval format and probability density functions. It could thus improve upon the existing bi-level multi-objective programming through addressing discrete interval parameters and dual-randomness p valuable tool for generating a range of decision alternatives and thus assists the bi-level decision-makers to identify the desired water resources allocation schemes under multiple scenarios.A novel form of sodalite was synthesized from muscovite (M.SD) as low-cost softening material for both Ca2+ and Mg2+ ions from real groundwater in batch and column studies. The sodalite sample showed significant surface area (105 m2/g) and ion exchange capacity (87.3 meq/100 g) which qualifies it strong for softening applications. The incorporation of the M.SD as a fixed bed in column system at a fixed thickness of 4 cm and flow rates of 5 mL/min resulted in removal percentages of 90.5% and 92.2% for Ca2+ and Mg2+, respectively at pH 7.6. Considering the real concentrations of the ions (Ca2+ (233 mg/L) and Mg2+ (114 mg/L)), the M.SD bed has the ability to reduce their concentrations according to the recommended limits (75 mg/L for Ca2+ and 50 mg/L for Mg2+). These conditions resulted in purification of about 8.1 L and 8.7 L with breakthrough intervals of 1380 min and 1440 min; and saturation interval more than 1620 min for Ca2+ and Mg2+, respectively. The M.SD columns' performances were described considering the assumption of the Thomas model, Adams-Bohart model, and Yoon-Nelson model. The batch studies demonstrate the uptake of both Ca2+ and Mg2+ ions according to the Pseudo-First order kinetics and Langmuir equilibrium behaviour. link2 Considering the values of Gaussian energies (0.77 KJ/mol (Ca2+) and 1.36 KJ/mol (Mg2+)), the uptake of these ions occurred by homogenous reactions of monolayer form and physical nature. The thermodynamic studies declared the spontaneous properties of the reactions and their exothermic properties.Heat stress (HS) is one of the main environmental factors affecting the efficiency of poultry production. The yellow-feather chickens (YFC) as an indigenous strain of chicken is a popular poultry breed in China. Our previous study used the RNA-seq to analyze the gene expression profiles of male YFC under HS and showed that the lipid and energy metabolism pathways are activated in livers of YFC exposed to acute HS (38°C, 4 h and 25°C recovery 2 h). In this study, we used quantitative proteome analysis based on iTRAQ to study the liver response of YFC to cycle chronic HS (38 ± 1°C, 8 h/d, 7 d, CyCHS). The male YFCs treatment used the CyCHS from 22 to 28 days of age. The liver tissue samples were collected at 28 d old. A total of 39,327 unique peptides matches were detected using iTRAQ analysis and 4,571 proteins exhibited a false discovery rate of 1% or less. Forty-six significant differentially expressed proteins (DEPs) were detected in the CyCHS group compared with the control group for the liver samples, incd future studies will investigate the functional genes associated with the response to HS.Chicken semen cryopreservation is a tool for programs of genetic diversity management and endangered breeds conservation. Due to physiological features, the fertility rates of cryopreserved poultry sperm are lower than mammal species. Thus, improvement of the semen cryopreservation methods is required. link3 A first study was performed by a 2 × 2 factorial design consisting of 2 methods of adding the cryoprotectant [Direct or Diluted (mixed with extender medium)] and 2 cryoprotectants (glycerol and dimethylacetamide). Then sperm quality indicators were evaluated after freezing. A second study with a 2 × 2 design was conducted to evaluate the effectiveness of bovine serum albumin (BSA) on the optimization of 2 different extenders (Lake and Animal Sciences Group [ASG]). Viability and motility variables were evaluated before and after freezing. There was no significant difference in sperm viability and motility variables between Direct or Diluted methods. Supplementation of extenders with BSA improved most of the sperhigher post-thaw sperm viability in ASG medium.Cavity nesting bees are proficient and important pollinators that can augment or replace honey bee pollination services for some crops. Relatively little is known about specific pesticide concentrations present in cavity nesting insect reed matrices and associated potential risks to cavity nesting bees. Nesting substrates (Phragmites australis reeds in bundles) were deployed in an agriculturally intensive landscape to evaluate colonization and agrochemical exposure among cavity nesting pollinators over two consecutive field seasons. Composition of insect species colonizing reeds within nest bundles varied considerably; those placed near beef cattle feed yards were dominated by wasps (93% of the total number of individuals occupying reed nest bundles), whereas nest bundles deployed in cropland-dominated landscapes were colonized primarily by leaf cutter bees (71%). All nesting/brood matrices in reeds (mud, leaves, brood, pollen) contained agrochemicals. Mud used in brood chamber construction at feed yard sites contained 21 of 23 agrochemicals included in analysis and >70% of leaf substrate stored in reeds contained at least one agrochemical. Moxidectin was most frequently detected across all reed matrices from feed yard sites, and moxidectin concentrations in nonviable larvae were more than four times higher than those quantified in viable larvae. Agrochemical concentrations in leaf material and pollen were also quantified at levels that may have induced toxic effects among developing larvae. To our knowledge, this is the first study to characterize agrochemical concentrations in multiple reed matrices provisioned by cavity-nesting insects. Use of nest bundles revealed that cavity nesting pollinators in agriculturally intensive regions are exposed to agrochemicals during all life stages, at relatively high frequencies, and at potentially lethal concentrations. These results demonstrate the utility of nest bundles for characterizing risks to cavity nesting insects inhabiting agriculturally intensive regions.