Matzenglenn1325

Considering the exceptional growth of Cyber Physical Systems (CPSs), multiple and potentially grave security challenges have emerged in this field. Different vulnerabilities and attacks are present in front of new generation CPSs, such as Industrial CPS (I-CPS). The underlying non-uniform standards, device heterogeneity, network complexity, etc., make it difficult to offer a systematized coverage on CPS security in an industrial environment. This work considers the security perspective of I-CPSs, and offers a decade-wide survey including different vulnerabilities, attacks, CPS components, and various other aspects. The comparative year-wise analysis of the existing works w.r.t objective, approach referred, testbed used and derived inference, is also presented over a decade. Additionally, the work details different security issues and research challenges present in I-CPS. This work attempts to offer a concise and precise literature study focused on the state-of-the-art I-CPS security. This work also encourages the young researchers to explore the wide possibilities present in this emerging field.

In recent years, advances in pharmacotherapy for rheumatoid arthritis (RA) have dramatically improved the control of disease activity. However, a significant number of patients still develop forefoot deformity. The purpose of this study was to investigate the results of more than 20 years' follow-up of metatarsal neck shortening oblique osteotomy (SOO) for forefoot deformity in patients with RA.

The metatarsal neck SOO was performed on 163 feet in 108 patients between January 1985 and December 1996 in the authors' hospital. For the patients, who met the survey criteria, an observational study was performed clinically and radiologically at the baseline and at more than 20 years after surgery.

A retrospective cohort study was conducted on 36 feet in 22 patients, all of whom were female, and the mean age at surgery was 45.6 (35.0-63.0) years old. The follow-up period was 25.1 (21.0-31.0) years. The presence of painful callosities in the surgically treated feet without revised surgeries decreased from 32 feet (100%) to 4 feet (12.5%) at the last follow-up with mild pain that did not cause any footwear problems. Re-osteotomy at the metatarsal of the lessor toe was performed on four feet in two patients. Radiologically, among 128 toes without revised surgeries, 85% were able to have the joint space preserved, and 89% maintained a pain-free condition without any recurrence of deformity. The mean total Japanese Society for Surgery for the Foot (JSSF) RA foot and ankle score was 64.0/100, and the visual analogue scale (VAS) of overall satisfaction was 62 (0 dissatisfied, 100 highly satisfied). The overall satisfaction had a positive correlation with calcaneal pitch and negative correlation with joint space narrowing at the talocrural joint.

Metatarsal neck SOO appeared to be effective for patients with RA. The deformity was corrected and retained for a long time.

Metatarsal neck SOO appeared to be effective for patients with RA. The deformity was corrected and retained for a long time.

This prospective trial investigates side effects and efficacy of focal dose escalation with brachytherapy for patients with prostate cancer.

In the Phase II, monocentric prospective trial 101 patients with low-/intermediate- and high-risk prostate cancer were enrolled between 2011 and 2013. Patients received either PDR-/HDR-brachytherapy alone with 86-90 Gy (EQD2, α/β = 3 Gy) or PDR-/HDR-brachytherapy as boost after external beam radiation therapy up to a total dose of 91-96 Gy (EQD2, α/β = 3 Gy). Taking place brachytherapy all patients received the simultaneous integrated focal boost to the intra-prostatic tumor lesions visible in computer-aided ultrasonography (HistoScanning™) - up to a total dose of 108-119 Gy (EQD2, α/β = 3 Gy). The primary endpoint was toxicity. Secondary endpoints were cumulative freedom from local recurrence, PSA-free survival, distant metastases-free survival, and overall survival. This trial is registered with ClinicalTrials.gov, number NCT01409876.

Median follow-up was 65 mont is safe and effective.

To evaluate the feasibility, early toxicity, and clinical outcomes of early-breast cancer patients in a single-arm, phase I/II study of an ultra-accelerated, four-fraction schedule of minimal breast irradiation (4f-AMBI) using a multicatheter, minimally-invasive, intraoperative tumor bed implant (MITBI) during breast-conserving surgery (BCS).

Eligible women aged >40 years with clinically and radiologically confirmed, unifocal invasive or in situ ≤3 cm tumors were considered as potential candidates for MITBI during BCS. After the pathology report, patients who met APBI criteria received ultra-accelerated four-fractions irradiation (6.2 Gy BID x 4fx over 2 days) with perioperative HDR-brachytherapy (PHDRBT). Early complications, toxicity, clinical outcomes, and cosmetic results were analyzed.

Of 89 patients initially implanted, 60(67.4%) were definitively included in the 4f-AMBI-protocol. The median age was 64.4 years; the median CTV was 32.1 cc (6.9-75.4 cc), and the external-V

was 43.1 cc (12.87-10rocedure is safe, dosimetrically feasible, and shows small irradiated volumes. This program provides low toxicity rates and excellent short-term clinical and cosmesis outcomes.

To evaluate the survival impact of adding definitive pelvic radiation therapy (RT) to chemotherapy among patients with stage IVB neuroendocrine cervical carcinoma (NECC).

We retrospectively studied patients with FIGO 2018 stage IVB NECC diagnosed during 1998-2020 who received chemotherapy with or without definitive whole pelvic RT (concurrent or sequential). Demographic, oncologic, and treatment characteristics were summarized. Progression-free (PFS) and overall survival (OS) were plotted using the Kaplan-Meier method, and hazard ratios (HRs) were calculated using Cox regression.

The study included 71 patients. Median age was 43 years (range, 24-75). CTx648 Fifty-nine patients (83%) had pure neuroendocrine histology, and 57 (80%) had pretreatment tumor size >4 cm. Fifty-six patients (79%) received chemotherapy alone with (n = 15) or without (n = 41) palliative pelvic RT, and 15 (21%) received chemotherapy and definitive pelvic RT (chemo+RT). Median follow-up time was 20.1 months (range, 11.3-170.3) for the chemo+RT group and 13.5 months (range, 0.9-73.6) for the chemotherapy-alone group. Median PFS was 10.3 months (95% CI, 7.5-∞) for the chemo+RT group vs 6.6 months (95% CI, 6.1-8.7) for the chemotherapy-alone group (p = 0.0097). At 24 months, the PFS rate was 24% for chemo+RT vs 7.8% for chemotherapy alone. Median OS was 20.3 months (95% CI, 18.5-∞) for the chemo+RT group vs 13.6 months (95% CI, 11.3-19.2) for the chemotherapy-alone group (p = 0.0013). At 24 months, the OS rate was 49.2% for chemo+RT vs 21.5% for chemotherapy alone. In a Cox regression model, definitive RT was associated with improved PFS (HR, 0.44; 95% CI, 0.23-0.83; p = 0.0119) and OS (HR, 0.31; 95% CI, 0.14-0.65; p = 0.0022).

Addition of definitive pelvic RT to chemotherapy may improve survival in patients with stage IVB NECC.

Addition of definitive pelvic RT to chemotherapy may improve survival in patients with stage IVB NECC.

Sarcopenia is associated with complications and inferior oncologic outcomes in solid tumors. Axial computed tomography (CT) scans can be used to evaluate sarcopenia, however manual quantification is laborious. We sought to validate an automated method of quantifying muscle cross-sectional area (CSA) in patients with pancreatic adenocarcinoma (PDAC).

Mid-L3 CT images from patients with PDAC were analyzed CSAs of skeletal muscle (SM) were measured using manual segmentation and the software AutoMATiCA, and then compared with linear regression.

Five-hundred-twenty-five unique scans were analyzed. There was robust correlation between manual and automated segmentation for L3 CSA (R

0.94, P<0.001). Bland-Altman analysis demonstrated a consistent overestimation of muscle CSA by AutoMATiCA with a mean difference of 5.7%. A correction factor of 1.06 was validated using a unique test dataset of 36 patients with non-PDAC peripancreatic malignancies.

Automated muscle CSA measurement with AutoMATiCA is highly efficient and yields results highly correlated with manual measurement. These findings support the potential use of high-throughput sarcopenia analysis with abdominal CT scans for both clinical and research purposes.

Automated muscle CSA measurement with AutoMATiCA is highly efficient and yields results highly correlated with manual measurement. These findings support the potential use of high-throughput sarcopenia analysis with abdominal CT scans for both clinical and research purposes.

Over the past 2 decades, podcasting has become an easy and inexpensive way to disseminate information. Given the increasing importance of podcasts in medicine and medical education, it is important to understand the current status of diverse voices on podcasts. The primary objective of this study was to describe the distribution of women and men as hosts and guest speakers among 3 popular emergency medicine podcasts across a 10-year period. The secondary objective was to evaluate the association between host gender and speaker gender.

We performed a retrospective cohort study of the gender distribution of hosts and guest speakers among 3 popular emergency medicine podcasts from July 2011 to June 2021. Data were extracted and their gender determined using pronouns listed in their faculty profiles or using Genderize. The data were presented descriptively using subanalyses by year and the type of speaker. We calculated the odds ratio (OR) with 95% confidence interval (CI) for the likelihood of a single host predicting a speaker's gender.

We identified 2,834 podcasts (n=5,962 speakers), with 964 (16.2%) women and 4,996 (83.8%) men speakers. Among hosts, 10.2% were women and 89.8% were men, whereas among guest speakers, 23.4% were women and 76.5% were men. The distribution of women speakers increased from 9.1% in 2011 to 23.1% in 2021. Having a woman host had an OR of 2.40 (95% CI 1.72 to 3.34) for having a woman guest speaker, whereas having a man host had an OR of 0.42 (95% CI 0.30 to 0.58) for having a woman guest speaker.

Among the 3 popular emergency medicine podcasts, there are few women speakers, hosts, and guest speakers; however, the proportion has risen over the past 10 years.

Among the 3 popular emergency medicine podcasts, there are few women speakers, hosts, and guest speakers; however, the proportion has risen over the past 10 years.

To examine the distribution of hospitalized COVID-19 patients among adult acute care facilities in the Greater Philadelphia area and identify factors associated with hospitals carrying higher burdens of COVID-19 patients.

In this observational descriptive study, we obtained self-reported daily COVID-19 inpatient censuses from 28 large (>100 beds) adult acute care hospitals in the Greater Philadelphia region during the initial wave of the COVID-19 pandemic (March 23, 2020, to July 28, 2020). We examined hospitals based on their size, location, trauma certification, median household income, and reliance on public insurance. COVID-19 inpatient burdens (ie, beds occupied by COVID-19 patients), relative to overall facility capacity (ie, total beds), were reported and assessed using thresholds established by the Institute of Health Metrics and Evaluation to approximate the stress induced by different COVID-19 levels.

Maximum (ie, peak) daily COVID-19 occupancy averaged 27.5% (SD 11.2%) across the 28 hospitals.