Mattinglyosborn0722

increasingly, research suggests that lack of sleep is linked to adiposity worldwide, but few studies have been conducted in middle-aged and elderly Chinese subjects. The purpose of the present study was to analyze the association of siesta and nocturnal sleep duration with the prevalence of adiposity in middle-aged and elderly Chinese individuals.

a total of 7,891 community dwelling Chinese subjects who had participated in the 2015 China Health and Retirement Longitudinal Study were included. A four-stage random sampling method was used to select participants. Siesta and nocturnal sleep duration was self-reported. Adiposity, including general obesity and abdominal obesity, was assessed. Multiple logistic analyses were conducted to explore the association between siesta, nocturnal sleep duration, and adiposity.

people with long siesta durations (≥ 1 hour/day) were significantly associated with an increased risk for abdominal obesity, independently and in all subgroup analyses, when compared to those without regular siesta. ORs after adjustment of confounding factors included all subjects, OR = 1.45, 95 % CI, 1.23 to 1.70; middle-aged subjects, OR = 1.46, 95 % CI, 1.15 to 1.86; elderly, OR = 1.43, 95 % CI, 1.14 to 1.78.

our data show that siesta duration plays a role in the prevalence of age-specific abdominal obesity. Individuals with long siesta durations are more likely to have abdominal obesity among the middle-aged and elderly population when compared to those without regular siesta. The results of this study need to be confirmed by further studies.

our data show that siesta duration plays a role in the prevalence of age-specific abdominal obesity. Individuals with long siesta durations are more likely to have abdominal obesity among the middle-aged and elderly population when compared to those without regular siesta. The results of this study need to be confirmed by further studies.Oxidopyrylium [5 + 2] cycloaddition reactions are powerful strategies for constructing complex bicyclic architectures. However, intermolecular cycloadditions of oxidopyrylium ylides are limited due to competing dimerization processes; consequently, high equivalents of dipolarophiles are often used to help intercept the ylide prior to dimerization. Recent studies by our lab have revealed that oxidopyrylium dimers derived from 3-hydroxy-4-pyrones are capable of reverting back to ylides in situ and as a result can be used as clean oxidopyrylium ylide sources. The following manuscript investigates intermolecular cycloaddition reactions between 3-hydroxy-4-pyrone-derived oxidopyrylium dimers and stoichiometrically equivalent ratios of alkyne dipolarophiles under thermal conditions. With certain reactive alkynes, pure cycloadducts can be obtained following a simple evaporation of the solvent, which is a benefit of the completely atom-economical reaction conditions. However, when less reactive alkynes are used the yields suffer due to a competing dimer rearrangement. Finally, when reactive-yet-volatile alkynes are used, such as methyl propiolate, competing 21 ylide/alkyne cycloadducts are observed. Intriguingly, these complex cycloadducts, which can be obtained in good yields from the pure cycloadducts, form with high regio- and stereoselectivities; however, both the regio-and stereoselectivities differ remarkably based on the source of the oxidopyrylium ylide.Deterium-labeled (hetero)aryl bromide is one of the most widespread applicable motifs to achieve important deuterated architectures for various scientific applications. Traditionally, these deterium-labeled (hetero)aryl bromides are commonly prepared via multistep syntheses. Herein, we disclose a direct H/D exchange protocol for deuteration of (hetero)aryl bromides using Ag2CO3 as catalyst and D2O as deuterium source. This protocol is highly efficient, simply manipulated, and appliable for deuterium-labeling of over 55 (hetero)aryl bromides including bioactive druglike molecules and key intermediates of functional materials. learn more In addition, this method showed distinguishing site-selectivity toward the existing transition-metal-catalyzed HIE process, leading to multideuterated (hetero)aryl bromides in one step.In an earlier investigation, amorphous celecoxib was shown to be sensitive to compression-induced destabilization. This was established by evaluating the physical stability of uncompressed/compressed phases in the supercooled state (Be̅rziņš . Mol. Pharmaceutics, 2019, 16(8), 3678-3686). In this study, we investigated the ramifications of compression-induced destabilization in the glassy state as well as the impact of compression on the dissolution behavior. Slow and fast melt-quenched celecoxib disks were compressed with a range of compression pressures (125-500 MPa) and dwell times (0-60 s). These were then monitored for crystallization using low-frequency Raman spectroscopy when kept under dry (∼20 °C; less then 5% RH) and humid (∼20 °C; 97% RH) storage conditions. Faster crystallization was observed from the samples, which were compressed using more severe compression parameters. Furthermore, crystallization was also affected by the cooling rate used to form the amorphous phases; slow melt-quenched samples exhibited higher sensitivity to compression-induced destabilization. The behavior of the melt-quench disks, subjected to different compression conditions, was continuously monitored during dissolution using low-frequency Raman and UV/vis for the solid-state form and dissolution properties, respectively. Surprisingly the compressed samples exhibited higher apparent dissolution (i.e., higher area under the dissolution curve and initial celecoxib concentration in solution) than the uncompressed samples; however, this is attributed to biaxial fracturing throughout the compressed compacts yielding a greater effective surface area. Differences between the slow and fast melt quenched samples showed some trends similar to those observed for their storage stability.A catalytic enantioselective reduction of α-trifluoromethylated imines by a BINOL-derived boro-phosphate employing catecholborane as hydride source has been developed. This method provides an efficient route to prepare synthetically useful chiral α-trifluoromethylated amines in high yields and with excellent enantioselectivities (up to 98% yield and 96% ee) under mild conditions.