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This article argues that despite a resurgence in research on psychedelics over the last two decades, we still have little insight into the psychedelics user population. Furthermore, there is currently little agreement between researchers as to the long-term mental health consequences of psychedelics use.

In a methodological review of a range of studies in psychedelics use, it is demonstrated that these studies tend to focus on specific segments of the user population while excluding others. These population segments are probably connected to different patterns of use, which in turn are likely to result in different long-term consequences.

The divergent findings on the consequences of psychedelics use may be explained, at least in part, by the fact that different research strategies explore different segments of the user population. Studies focusing on user segments with problematic usage patterns tend to find that psychedelics use is negative for mental health, while studies on infrequent users tend to find that psychedelics use is positive for mental health.

Because the field of psychedelics studies lacks a reliable model of the user population, it is difficult for researchers to contextualise and assess the broader validity of their findings. To remedy this situation, the article presents three theoretical models of the user population that afford us with tentative means of contextualising findings and thereby may clarify present disagreements.

Because the field of psychedelics studies lacks a reliable model of the user population, it is difficult for researchers to contextualise and assess the broader validity of their findings. MS1943 clinical trial To remedy this situation, the article presents three theoretical models of the user population that afford us with tentative means of contextualising findings and thereby may clarify present disagreements.

To end the hepatitis and AIDS epidemics in the world by 2030, countries are encouraged to scale-up harm reduction services and target people who inject drugs (PWID). Blood-borne viruses (BBV) among PWID spread via unsterile injection equipment sharing and to combat this, many countries have introduced needle and syringe exchange programmes (NEP), though not without controversy. Sweden's long, complicated harm reduction policy transition has been deviant compared to the Nordic countries. After launch in 1986, no NEP were started in Sweden for 23 years, the reasons for which are analysed in this study.

Policy documents, grey literature and research mainly published in 2000-2017 were collected and analysed using a hierarchical framework, to understand how continuous build-up of evidence, decisions and key events, over time influenced NEP development.

Sweden's first NEP opened in a repressive-control drug policy era with a drug-free society goal. Despite high prevalence of BBV among PWID with recurring outbreaks, growing research and key-actor support including a NEP law, no NEP were launched. Political disagreements, fluctuating actor-coalitions, questioning of research, and a municipality veto against NEP, played critical roles. With an individual-centred perspective being brought into the drug policy domain, the manifestation of a dual drug and health policy track, a revised NEP law in 2017 and removal of the veto, Sweden would see fast expansion of new NEP.

Lessons from the Swedish case could provide valuable insight for countries about to scale-up harm reduction services including how to circumvent costly time- and resource-intensive obstacles and processes involving ideological and individual moral dimensions.

Lessons from the Swedish case could provide valuable insight for countries about to scale-up harm reduction services including how to circumvent costly time- and resource-intensive obstacles and processes involving ideological and individual moral dimensions.

Minimum Pricing for Alcohol (MPA) was enacted in Wales on March 2

2020. During the legislative process (i.e. consultation and parliamentary discussion), concern was expressed about the possibility of some drinkers switching to using other substances in response to any rise in the cost of alcohol. This paper reports on findings from a study which explored these pre-implementation concerns and how the policy was shaped.

The research involved surveys (n=193) and interviews (n=87) with drinkers (predominantly harmful or treatment seeking) and providers of services. Survey responses were detailed, thus when combined with the interviews, provided a wealth of qualitative data, which are drawn upon in this paper.

The findings highlight an expectation that most drinkers would respond to the new policy with adaptations of their coping mechanisms to maintain alcohol use at pre-legislative levels. This was either by switching alcohol products and adjusting their lifestyle to maintain an affordable drinking habit or developing new behaviours to manage additional costs. A small group of those with previous experience of drug use were identified as likely to switch from using alcohol to some other substances.

Prior to the legislation being implemented awareness of the detail of the policy was found to be low, and the perceptions of increased potential harm for certain groups, including switching, were linked to concern about a lack of treatment capacity.

Prior to the legislation being implemented awareness of the detail of the policy was found to be low, and the perceptions of increased potential harm for certain groups, including switching, were linked to concern about a lack of treatment capacity.

This study attempts to demonstrate the relevance of the socio-cultural model of drugs in explaining the impressive development of ecstasy in the last 45 years.

First the study describes the use of ecstasy by groups which have left their imprint on the substance university students, gays, yuppies and the "New Age" movement. Then the link between ecstasy and techno music led to the socially integrated "club" phenomenon, and the "rave", which began as a rupturing, nonconformist phenomenon.

According to this argument, in spite of its clearly counterculture beginnings, the "rave" movement and its most characteristic drug, ecstasy, have gradually become integrated into mainstream culture, somehow reinforcing the functioning of capitalist postmodernity. Our study explains ecstasy's history in reference to the cultural contradictions of capitalism and the functions that it currently fulfils for young people. Based on this analysis, the implications of the cultural perspective are discussed as a paradigm of research in drug use, stressing notions of subculture, myths and rituals. It also proposes a harmonious articulation of academic and common knowledge as the most appropriate method for their study.

A cultural approach to drug use could assist in unblocking a field so in need of conceptual and empirical revision.

A cultural approach to drug use could assist in unblocking a field so in need of conceptual and empirical revision.

To describe the knowledge, attitudes and practices of self-medication in college students and to analyse the predicting factors for the engagement in that behaviour.

This is a cross-sectional study involving students (

= 840) from a Portuguese university, selected through stratified and proportional sampling. Data were collected using a self-administered questionnaire containing, in addition to sociodemographic issues, a scale measuring knowledge about self-medication (α = .488), a scale measuring attitudes towards self-medication (α = .708) and questions about the patterns of self-medication practices (α = .445). Differences between outcomes and sociodemographics were analysed through independent

-tests and ANOVA. A generalised linear model was calculated to determine the predictive variables of self-medication.

Over half of the respondents ( 54.3%,

= 434) had used some form of self-medication during the preceding year. Students revealed poor knowledge about the referred practice, correctly answcorrect positioning towards self-medication. Therefore, the recommendation to develop campaigns or educational programmes becomes obvious, in order to inform about the adverse effects of the use of non-prescribed medicine.

Brazil has been severely impacted by COVID-19 pandemics that is aggravated by the absence of a scientifically-driven coordinated informative campaign and the interference in public health management, which ultimately affected health measures to avoid SARS-CoV2 spread. The decentralization and resultant conflicts in disease control activities produced different protection behaviours and local government measures. In the present study, we investigated how political partisanship and socio-economic factors determined the outcome of COVID-19 at the local level in Brazil.

A retrospective study of COVID-19 deaths was carried out using mortality databases between Feb 2020, and Jun 2021 for the 5570 Brazilian municipalities. Socio-economic parameters including city categories, income and inequality indexes, health service quality and partisanship, assessed by the result of the second round of the 2018 Brazilian presidential elections, were included. Regression tree analysis was carried out to identify the statistior the Improvement of Higher Education Personnel (CAPES), National Council for Scientific and Technological Development (CNPq).

International joint laboratories of Institute de Recherche pour le Développement, a partnership between the University of Brasília and the Oswaldo Cruz Foundation (LMI-Sentinela - UnB - Fiocruz - IRD), Coordination for the Improvement of Higher Education Personnel (CAPES), National Council for Scientific and Technological Development (CNPq).Although sub-Saharan Africa has the world's highest rates of early pregnancy, there is little awareness of pregnancy and parenting among young people in out-of-home care in this region. Therefore, this study looked into the experiences of pregnancy and parenting among young women who had been in residential care in Ghana and Uganda. We gathered data from ten parenting care leavers in both countries using semi-structured interviews and then analyzed the data from the interviews thematically. The study's findings revealed that the young mothers had minimal sexual and reproductive health education, as well as a lack of sufficient monitoring, which predisposed them to early pregnancy. The young mothers indicated that emotional stress, financial and employment obstacles, as well as stigma, were some challenges they had experienced. They used personal motivation and spirituality as coping mechanisms to deal with their challenges. Training caregivers to deliver sexual and reproductive health information, having practitioners who will offer supervision during the semi-independent phase of leaving care, and providing separate housing for young mothers are some implications for practice emerging from the study. Policy implications include the need for social inclusion programs to support the academic, vocational, and parenting skills of young mothers who leave care.

For estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC), the current standard first-line treatment includes an aromatase inhibitor in combination with a cyclin-dependent kinase 4/6 inhibitor. When resistance occurs, often related to the occurrence of

mutations, selective estrogen receptor modulators or degraders (SERDs) may be used, alone or in combination regimens. Amcenestrant (SAR439859), an optimized oral SERD, has shown clinical antitumor activity in combination with palbociclib in patients with ER+/HER2- ABC and, as monotherapy, in patients with and without

mutations. Here, we describe the study design of AMEERA-5, an ongoing, prospective, phase 3, randomized, double-blind, multinational study comparing the efficacy and safety of amcenestrant plus palbociclib

letrozole plus palbociclib in patients with advanced (locoregional recurrent or metastatic) ER+/HER2- breast cancer.

Patients are pre-/postmenopausal women and men with no prior systemic therapy for ABC.