Martinsenstaal1904

The current density of PtPd@MBP and Pd@MBP NPs were 3.35 and 2.72 A mg-1, respectively. Such MBP synthesized and encapsulated nanoparticles open a new frontier for the design and preparation of NPs for various applications, such as catalysis, bioremediation and drug delivery.

Grafting nanoparticles surfaces with water-soluble polymers modify interparticle interactions that are pivotal for assembling them into ordered phases. By manipulating salt concentrations of gold nanoparticles (AuNPs) that are grafted with poly(N-isopropylacrylamide) (PNIPAM-AuNPs), we hypothesize that various aggregated phases form at the suspension/vapor interface or in the bulk that depend on the molecular weight (MW) of PNIPAM and on salt concentrations.

AuNPs are grafted with thiolated PNIPAM of molecular weights of 3 or 6kDa, and grafting is confirmed by dynamic light scattering. Liquid-surfaces X-ray reflectivity and grazing incidence small-angle X-ray scattering are used to determine the density profiles of the suspension/vapor interface and their inplane structure as salt is added to the suspensions.

We find that surface enrichment is induced by adding NaCl to the suspensions, and that at low salt concentrations, the monoparticle layer formed is dispersed, and above a threshold salt concentration, depending on MW of PNIPAM, the PNIPAM-AuNPs order in a hexagonal structure. We show that the lattice constant of the two-dimensional hexagonal structure varies with salt concentration, and more significantly with MW of PNIPAM.

We find that surface enrichment is induced by adding NaCl to the suspensions, and that at low salt concentrations, the monoparticle layer formed is dispersed, and above a threshold salt concentration, depending on MW of PNIPAM, the PNIPAM-AuNPs order in a hexagonal structure. We show that the lattice constant of the two-dimensional hexagonal structure varies with salt concentration, and more significantly with MW of PNIPAM.

Frequent nightmares and depression are associated with non-suicidal self-injury (NSSI) in adolescents. Little is known about the mediating role of depression in the nightmare-NSSI link. This study explores the longitudinal mediating effect of depression on the relationship between frequent nightmares and NSSI as well as the moderating effect of gender using a three-wave longitudinal design.

Participants were adolescents from the Shandong Adolescent Behavior and Health Cohort who were surveyed at baseline, 1 year later, and 2 years later. A self-administered questionnaire was used to measure nightmare frequency, depression, and NSSI. Structural equation modeling and multiple-group analysis were used to test the mediating effect of depression and the moderating effect of gender. Covariates included demographics and earlier measures of depression and NSSI.

Among 6995 participants, 3399 (48.6%) were females, mean age was 14.86 (SD=1.50) years at baseline. Frequent nightmares had a significant mediation effect on NSSI through depression (B

=0.06, 95% CI=0.02-0.10) after controlling for demographics and earlier measures of depression and NSSI. Gender had no significant moderating effect on the nightmare-NSSI association.

All data were collected by self-report.

The association between frequent nightmares and NSSI in adolescents was partially mediated by depression. Frequent nightmares and depression should be assessed and treated to prevent self-harm in adolescents.

The association between frequent nightmares and NSSI in adolescents was partially mediated by depression. Frequent nightmares and depression should be assessed and treated to prevent self-harm in adolescents.

Many countries have implemented alcohol excise taxes. However, measures of excise taxes as a percentage of alcohol prices have not been systematically studied.

Data on the retail prices of alcoholic beverages sold in stores and excise taxes in 26 countries during 2003-2018 was from the Economist Intelligence Unit price city data and the Organization for Economic Co-operation and Development (OECD) tax database. The percentages of excise taxes in off-premise retail prices were derived as the ratio of taxes to prices at different price levels. Changes of excise taxes over time were assessed using negative binominal regressions.

The percentage of excise taxes in average off-premise alcohol prices was from 5 % in Luxembourg to 59 % in Iceland for beer, and from 0 % in France to 26 % in Iceland for wine. Excise taxes accounted for 5% of discount liquor prices in Czech Republic to 41 % in Sweden for Cognac, for 19 % in the United States (US) to 67 % in Sweden for Gin, for 13 % in the US to 63 % in Australia for Scotch Whisky six years old, and for 6 % in Iceland to 76 % in Sweden for Liqueur Cointreau. AZD1656 There were no significant changes in the percentage of excise taxes in alcohol prices over time in most countries except for Nordic countries. While wine had the lowest excise taxes, liquors had the highest tax burden.

Tax burden on alcoholic beverages is low in OECD countries, indicating ample room for increasing alcohol excise taxes, particularly for beer and wine in those countries.

Tax burden on alcoholic beverages is low in OECD countries, indicating ample room for increasing alcohol excise taxes, particularly for beer and wine in those countries.BACKGROUND Little is known regarding the sociodemographic and clinical characteristics of emergency department (ED) patients with untreated opioid use disorder (OUD) and the relationship of those characteristics with whether they were seeking a referral to substance use treatment at the time of their ED visit. METHODS Using data collected from 2/2017-1/2019 from participants enrolled in Project ED Health (CTN-0069), we conducted a cross-sectional analysis of patients with untreated moderate to severe OUD presenting to one of four EDs in Baltimore, New York City, Cincinnati, or Seattle. Sociodemographic and clinical correlates, and International Classification of Diseases Tenth Revision (ICD-10) diagnosis codes related to opioid withdrawal, injection-related infection, other substance use, overdose, and OUD of those seeking and not seeking a referral to substance use treatment on presentation were compared using univariate analyses. RESULTS Among 394 study participants, 15.2 % (60/394) came to the ED seeking a referral to substance use treatment. No differences in age, gender, education, health insurance status or housing stability were detected between those seeking and not seeking referral to substance use treatment. link2 Those seeking a referral to substance use treatment were less likely to have urine toxicology testing positive for amphetamine [17 % (10/60) vs 31 % (104/334), p = 0.023] and methamphetamine [23 % (14/60) vs 40 % (132/334), p = 0.017] compared to those not seeking a referral. CONCLUSION Most patients with untreated OUD seen in the EDs were not seeking a referral to substance use treatment. Active identification, treatment initiation, and coding may improve ED efforts to address untreated OUD.

Adults with mood and anxiety disorders have an increased likelihood of being prescribed opioids. The influence of other mental disorders, such as psychotic and attention disorders, on opioid prescribing patterns is less known.

We studied a population-representative sample of 166,927 outpatient visits for adults with painful conditions from the 2002-2016 National Ambulatory Medical Care Survey and the 2002-2011 National Hospital Ambulatory Medical Care Survey. Logistic regression analyses examined the likelihood of opioid prescription among visits with specific mental disorder diagnoses (anxiety, attention, mood, psychotic, post-traumatic stress disorder (PTSD), opioid use, and non-opioid substance use), adjusted for covariates and weighted for the complex survey design. Secondary analyses stratified results by whether opioids were newly initiated or continued.

Opioids were prescribed at 16.8 % of visits. Mood, anxiety, and non-opioid substance use disorders were associated with higher likelihoods of opioid prescriptions, particularly for continued rather than first-time prescriptions. Psychotic disorders were strongly negatively associated with opioid prescriptions (adjusted odds ratio 0.44, 95 % CI 0.22-0.86). Diagnoses of PTSD and attention disorders were not associated with opioid prescribing.

Outpatient physicians are more likely to prescribe and refill opioids for adults with pain who present with mood, anxiety, and non-opioid substance use disorders, but not for those who present with PTSD or attention disorders. Patients with psychotic disorders and pain are markedly less likely to be prescribed opioids.

Outpatient physicians are more likely to prescribe and refill opioids for adults with pain who present with mood, anxiety, and non-opioid substance use disorders, but not for those who present with PTSD or attention disorders. Patients with psychotic disorders and pain are markedly less likely to be prescribed opioids.Polychlorinated biphenyls (PCBs) are carcinogenic persistent organic pollutants that have been used as mixtures in transformers, electrical capacitors or hydraulic oils in underground mining until their ban in the late 1980s in Germany. The widespread use of PCBs has led to an age-dependent body burden in the general population. In order to determine the human half-lives of different PCB-congeners, we have used data collected between 2010 and 2017 from the prospective investigation of the German HELPcB-cohort with high initial occupational exposure to PCBs from a transformer recycling company. PCBs were quantified in plasma of the study participants in six cross-sectional investigations using gas-chromatography coupled to mass-spectrometry. Applying logistic regression on the individual plasma levels after statistical elimination of outliers, the elimination half-lives of 18 PCB-congeners were determined. Further stratifications were performed using adjustment for blood lipids, calculation of the total amount of PCB in the body and by using a statistical model taking into account the individual age-dependent background burden. The calculated plasma half-lives ranged from 0.8 years for PCB 52 until a maximum of 28.9 years for PCB 189, depending on the model applied. E.g. the total body amount related half-live for PCB 28 is 2.41 years, for PCB 74 it is 12.81 years, for PCB 118 it is 6.65 years and for PCB 153 = 10.75 years. The model with adjustment for age dependent background burden led to shorter half-lives. The analysis revealed structure-related differences in the kinetics for the PCB-congeners examined. Congeners with a chlorine substitution in 2,4,(5)- and 4'-position showed longer half-lives than other isomers with one (or two) free 4-positions. Due to the high number of included cases and repeated measurements, our results provide valid half-live data for a large number of PCB congeners. Using these data, a rough estimation of former occupational exposures from current PCB-levels seems feasible.

Despite diabetes being an independent risk for HF, only some DM patients develop HF and hence our aim was to compare the clinical features of DM with and without HF and non-DM with and without HF.

A retrospective observational study was conducted among 397 individuals who visited two tertiary care centres. They were classified into 4 groups - DM with HF(DM-HF), DM without HF, non-DM with HF(non-DM-HF) and non-DM without HF. link3 We assessed and compared the clinical profile of DM with HF vs. DM without HF and non-DM with HF groups respectively.

The parameters such as age, BMI, BP, eGFR showed significant difference between the groups. People with DM-HF were older compared to DM without HF group(58.9±9.2vs.49.5±9.3; p<0.001). An increasing trend was observed in HF prevalence with increasing duration of DM among the DM-HF group. DM-HF showed a higher prevalence of hypertension and coronary artery disease(CAD) by history than DM without HF group. DM-HF group(91.2%) had HF with preserved left ventricular ejection fraction(HFpEF) whereas a high proportion(43.