Martinjohansson3345

BACKGROUND The standard treatment for patients with unresectable locally advanced (LA) non-small cell lung cancer (NSCLC) is chemoradiotherapy (CRT). Consolidation therapy with durvalumab after CRT demonstrated survival benefits and was approved in Japan in July 2018. The use of immune checkpoint inhibitors (ICIs) is entering routine oncological practice, and here we investigate the feasibility of concurrent CRT for LA-NSCLC patients based on the PACIFIC criteria. METHODS We performed a retrospective study to evaluate the feasibility and efficacy of concurrent CRT prior to the approval of durvalumab. We assessed consecutive patients with LA-NSCLC treated with CRT between January 2012 and June 2018. RESULTS We analyzed a total of 108 consecutive patients who received radical thoracic radiotherapy and concurrent platinum-based chemotherapy. Of those patients, 105 (97%) completed the planned radiotherapy. Radiation pneumonitis was observed in 93 patients (85%), with a median of 130 days (range 41-317 days) from the initiation of radiation to the onset of the complication. Among the patients, 74 (69%) were considered eligible for consolidation therapy with durvalumab. The overall response rate was 64%, and the two-year survival rate was 63%. Patients who received an ICI after relapse were associated with significantly better survival than those who did not receive an ICI (two-year survival rate 87% vs. 41%, respectively; P = 0.001). CONCLUSIONS Prior to the approval of durvalumab, the clinical application of ICIs improved the outcome of patients with relapsed NSCLC after CRT for LA-NSCLC. The management of radiation pneumonitis remains a challenge following the approval of durvalumab. © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.In this communication, we have developed a facile and efficient procedure for the synthesis of diarylphosphate esters and amides. Using Zn(acac) 2 as the catalyst, the reaction of diarylphosphoryl azides with aliphatic alcohols and phe-nols through an unusual P-N bond cleavage provided a number of diarylphosphate esters in good yields (22 examples, up to 94%). Additionally, various diarylphosphate amides were achieved from the corresponding amines in excellent yields as well (8 examples, up to 96%). © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.An organic Na-ion battery is reported with a polyanionic 9,10-anthraquinone-2,6-disulfonate (Na2 AQ26DS, 130 mAh g-1 ) cathode and the Na-intercalated state (Na4 TP) of sodium terephthalate (Na2 TP, 255 mAh g-1 ) as the anode. The resulting full cells deliver the maximum discharge capacity of 131 mAh g-1 cathode in 0.5-3.2 V, simultaneously maintaining the average value of ≈62 mAh g-1 cathode during 1200 cycles (0.5 A g-1 , ≈4 C). These results are among the best performing organic sodium-ion full cells reported to date. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.In this study, single-mode microwave heating was applied in epitaxial growth of b-oriented MFI seed monolayer prepared by facile manual assembly, resulting in the formation of well-intergrown and highly b-oriented MFI film with few twins. It exhibited a precise molecular sieving property at a reaction temperature no higher than 100 °C within 2 hours, therefore making it possible for easy operation in an open environment. The capability for concurrent suppression of undesired out-of-plane twin growth and promotion of in-plane epitaxial growth rate under mild reaction conditions was attributed to the obvious superiority of single-mode microwave heating in comparison with conventional multi-mode microwave heating in aspects of microwave field uniformity and intensity. Our research indicated that the single-mode microwave heating technique could potentially be a useful tool for improving the microstructure and therefore the performance of diverse zeolite films. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.Heavy doping is inevitable for utilizing single-walled carbon nanotubes for wiring. However, the electrical conductivity of their films is currently as low as one tenth of the films made from typical metal pastes. Herein we report on metal-comparable electrical conductivity from single-walled carbon nanotube network films. We use ionic liquids and crown ether complexes for p-type and n-type doping, respectively. The encapsulation of counterions into carbon nanotubes promotes the conductivities in the range of 7000 S cm-1 , approximately ten times larger than those of undoped films. © 2020 Wiley-VCH Verlag GmbH & Co. read more KGaA, Weinheim.Diffusion of the analytes across the diffusion boundary layers and subsequently through the fiber coatings determines the extraction kinetics of solid-phase microextraction in aqueous matrices. Besides, the matrix effects can distort the behaviors of the analytes transferring across the diffusion boundary layers. However, these processes were always studied via certain simplification, which often left the mass transfer through the fiber coatings unconsidered and the matrix effects partially investigated. Herein, a comprehensive study on the mass transfer processes in direct immersion solid-phase microextraction was presented. Under different agitation speeds, it was determined that the mass transfer coefficients across the diffusion boundary layers were three to six orders larger than those through the fiber coatings. However, the mass transfer across the diffusion boundary layers was generally the major rate-limiting step. In addition, the shuttle effect and the barrier effect, which were responsible for accelerating and retarding the extraction kinetics, respectively, were found to be the dominant matrix effect alternately under different agitation speeds. This study comprehensively illustrated the major rate-limiting step and the dominant matrix effects through recording the mass transfer coefficients. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.In this study, FoxO1 transgenic mice (transgenic, FoxO1-Tg) and C57BL/6 wild-type (wild-type, FoxO1-WT) mice were used to establish chronic colitis by drinking water containing dextran sulphate sodium (DSS). Afterwards, we observed the life changes in mice and assessed the pathological changes by H&E tissue staining. In addition, the TLR4/MyD88/MD2-NF-κB inflammatory signals were detected. As a result, under DSS treatment, the activation level of TLR4/MyD88/MD2-NF-κB inflammatory signal was higher in FoxO1-Tg mice than that in FoxO1-WT mice. Meanwhile, the intestinal mucosal tissue damage was more severe, the down-regulation of tight junction protein level was more significant and the life quality was decreased to a higher degree in FoxO1-Tg mice compared with those in FoxO1-WT mice. Caco-2 cells were used to mimic the intestinal mucosal barrier model for in vitro assays. In addition, lentiviral packaging FoxO1 overexpressing plasmid was transfected into Caco-2 cells for FoxO1 overexpression. TNF-α intervention was performed for intestinal mucosal inflammatory response model.