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Current deep learning methods seldom consider the effects of small pedestrian ratios and considerable differences in the aspect ratio of input images, which results in low pedestrian detection performance. This study proposes the ratio-and-scale-aware YOLO (RSA-YOLO) method to solve the aforementioned problems. The following procedure is adopted in this method. First, ratio-aware mechanisms are introduced to dynamically adjust the input layer length and width hyperparameters of YOLOv3, thereby solving the problem of considerable differences in the aspect ratio. Second, intelligent splits are used to automatically and appropriately divide the original images into two local images. Ratio-aware YOLO (RA-YOLO) is iteratively performed on the two local images. Because the original and local images produce low- and high-resolution pedestrian detection information after RA-YOLO, respectively, this study proposes new scale-aware mechanisms in which multiresolution fusion is used to solve the problem of misdetection of remarkably small pedestrians in images. The experimental results indicate that the proposed method produces favorable results for images with extremely small objects and those with considerable differences in the aspect ratio. Compared with the original YOLOs (i.e., YOLOv2 and YOLOv3) and several state-of-the-art approaches, the proposed method demonstrated a superior performance for the VOC 2012 comp4, INRIA, and ETH databases in terms of the average precision, intersection over union, and lowest log-average miss rate.Environment-friendly lead-free piezoelectric materials with excellent piezoelectric properties are needed for high frequency ultrasonic transducer applications. Recently, lead-free 0.915(K0.45Na0.5Li0.05)NbO3-0.075BaZrO3-0.01(Bi0.5Na0.5)TiO3 (KNLN-BZ-BNT) textured piezoelectric ceramics have high piezoelectric response, superior thermal stability, and excellent fatigue resistance, which are promising for devices applications. In this work, the KNLN-BZ-BNT textured ceramics were prepared by tape-casting method. Microstructural morphology, phase transition and electrical properties of KNLN-BZ-BNT textured ceramics were investigated. read more High frequency needle type ultrasonic transducers were designed and fabricated with these textured ceramics. The tightly focused transducers have a center frequency higher than 80 MHz and a -6 dB fractional bandwidth of 52%. Such transducers were built for an f-number close to 1, and the desired focal depth was achieved by press-focusing technology associated with a set of customer design fixture. Its lateral resolution was better than 90 μm by scanning a 15 μm tungsten wire target. These promising results demonstrate that the lead-free KNLN-BZ-BNT textured ceramic is a good candidate for high frequency ultrasonic transducer applications.Dementia is associated with severe spatial memory deficits which arise from dysfunction in hippocampal and parahippocampal circuits. For spatially sensitive neurons, such as grid cells, to faithfully represent the environment these circuits require precise encoding of direction and velocity information. Here, we have probed the firing rate coding properties of neurons in medial entorhinal cortex (MEC) in a mouse model of tauopathy. We find that grid cell firing patterns are largely absent in rTg4510 mice, while head-direction tuning remains largely intact. Conversely, neural representation of running speed information was significantly disturbed, with smaller proportions of MEC cells having firing rates correlated with locomotion in rTg4510 mice. Additionally, the power of local field potential oscillations in the theta and gamma frequency bands, which in wild-type mice are tightly linked to running speed, was invariant in rTg4510 mice during locomotion. These deficits in locomotor speed encoding likely severely impact path integration systems in dementia.Rare and complex connective tissue diseases (rCTDs) encompass a considerable number of diseases and syndromes and their variability highly impacts on the clinical management, resulting in variable economic and organisational burden that might represent a challenge for healthcare systems. This paper is aimed at providing an overview of the most recent evidence regarding the economic and organisational impact of rCTDs. In particular, this work discusses the most relevant data on specific aspects related to health economics in rCTDs published in 2019.The interindividual variability in the neural drive sent from the spinal cord to muscles is largely unknown, even during highly constrained motor tasks. Here, we investigated individual differences in the strength of neural drive received by the vastus lateralis (VL) and vastus medialis (VM) during an isometric task. We also assessed the proportion of common neural drive within and between these muscles. Twenty-two participants performed a series of submaximal isometric knee extensions at 25% of their peak torque. High-density surface electromyography recordings were decomposed into motor unit action potentials. Coherence analyses were applied on the motor unit spike trains to assess the degree of neural drive that was shared between motor neurons. Six participants were retested ∼20 mo after the first session. The distribution of the strength of neural drive between VL and VM varied between participants and was correlated with the distribution of normalized interference electromyography (EMG) signals (r > 0.5de evidence that the neural strategies to control the vastus lateralis and vastus medialis muscles widely vary across individuals, even during a mechanically constrained task.It has been proposed that movements are produced through groups of muscles, or motor modules, activated by common neural commands. However, the neural origin of motor modules is still debated. Here, we used complementary approaches to determine 1) whether three muscles of the same muscle group [soleus, gastrocnemius medialis (GM), and gastrocnemius lateralis (GL)] are activated by a common neural drive, and 2) whether the neural drive to GM and GL could be differentially modified by altering the mechanical requirements of the task. Eighteen human participants performed an isometric standing heel raise and submaximal isometric plantarflexions (10%, 30%, and 50% of maximal effort). High-density surface electromyography recordings were decomposed into motor unit action potentials and coherence analysis was applied on the motor unit spike trains. We identified strong common drive to each muscle but minimal common drive between the muscles. Further, large between-muscle differences were observed during the isometric plantarflexions, such as a delayed recruitment time of GL compared with GM and soleus motor units and opposite time-dependent changes in the estimates of neural drive to muscles during the torque plateau.

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