Marshmarshall6030

BACKGROUND AND OBJECTIVES Hemodynamics plays a crucial role in the progression of atherosclerosis and the treatment of arterial diseases. Stroke is one of the arterial diseases and a leading cause of death worldwide. Hemodynamics in the carotid artery plays a vital role in the stroke. The common carotid artery bifurcates into the internal carotid artery and the external carotid artery. Carotid sinus, a slightly dilated area, exists in the internal carotid artery just after the bifurcation and acts as a pressure receptor and regulator. The location and size of the sinus can vary in different people; the change in sinus size and location may affect the hemodynamics. It is necessary to study the shift in hemodynamics due to changes in sinus size and position on atherosclerosis. The change in flow behavior may suggest the probable sites of backflow and low wall shear stress, and therefore the sites prone to atherosclerosis. METHODS The model of the carotid artery has been constructed using patient data. Transientsinus away from bifurcation, and larger diameter sinus has more recirculation and low wall shear stress. Therefore, the person having sinus away from bifurcation and larger sinus diameter are more susceptible to plaque formation. V.BACKGROUND Duloxetine proved effective for treating pain in people with Parkinson's disease in a single-arm, open-label study. OBJECTIVE To evaluate the efficacy of duloxetine in a double-blind, randomized, placebo-controlled trial. METHODS We randomly assigned 46 patients with Parkinson's disease with pain to either the duloxetine 40 mg/day arm or the placebo arm. After 10 weeks, we tested the change from baseline in 24-hour average pain severity measured by a visual analogue scale. RESULTS We could not confirm the effect of duloxetine on pain. Exploratory analyses indicated that treatment with duloxetine was associated with improved scores on the Unified Parkinson's Disease Rating Scale Part III and 3 domains of the Parkinson's Disease Questionnaire - 39. CONCLUSIONS The study failed to provide evidence for the use of duloxetine for treating pain in people with Parkinson's disease. V.This study evaluates the fate of certain bactericidal agents introduced into microbial fuel cell (MFC) cascades and the response of the microbial community. We tested the response of functioning urine fed MFC cascades using two very different bactericidal agents a common antibiotic (Ampicillin, 5 g/L) and a disinfectant (Chloroxylenol 4.8 g/L) in concentrations of up to 100 times higher than the usual dose. Results of power generation showed that the established bacteria community was able to withstand high concentrations of ampicillin with good recovery after 24 h of minor decline. However, power generation was adversely affected by the introduction of chloroxylenol, resulting in a 99% loss of power generation. Ampicillin was completely degraded within the MFC cascade (>99.99%), while chloroxylenol remained largely unaffected. Analysis of the microbial community before the addition of the bactericidal agents showed a significant bacterial diversity with at least 35 genera detected within the cascade. Selleckchem Anlotinib Microbial community analysis after ampicillin treatment showed the loss of a small number of bacterial communities and proportional fluctuations of specific strains within the individual MFCs community. On the other hand, there was a significant shift in the bacterial community after chloroxylenol treatment coupled with the loss of at least 13 bacterial genera across the cascade. Crown V. All rights reserved.PURPOSE This study aimed to investigate the expression and biological function of miR-141-3p in nasopharyngeal carcinoma (NPC) via targeting neoplasm metastasis 1 (NME1). MATERIALS AND METHODS The expression of miR-141-3p and NME1 in 5-8F, C666-1, CNE-1, CNE-2, 6-10B and NP69 nasopharyngeal epithelial cells were detected using real-time Polymerase Chain Reaction (real-time PCR) and western blot, respectively. Cell proliferation was detected using Cell Counting Kit-8 (CCK-8), and the metastasis was detected using Transwell. The binding of miR-141-3p to NME1 was detected by dual luciferase reporter gene detection system. The effects of miR-141-3p on tumor growth were also determined in vivo. RESULTS The results showed that the expression of miR-141-3p significantly increased in various tumor cell lines and the expression of NME1 was higher in NP69 cells and lower in 5-8F cells, which had significant negative correlation. Furthermore, the expression of NME1 was significantly reduced after transfection of miR-141-3p and miR-141-3p promoted cell proliferation and metastasis. The double luciferase reporter gene detection system confirmed that NME1 was the target gene of miR-141-3p. Knockout of NME1 promoted the proliferation and metastasis of NP69 or 6-10B cells and the activation of p-Akt, which were abrogated by miR-141-3p. In vivo, the tumor volumes and weights in the miR-141-3p group significantly increased followed by down-regulation of NME1 and activation of p-Akt. CONCLUSIONS We confirmed that miR-141-3p promotes the proliferation and metastasis of NPC by targeting NME1. The solar/chlorine process is an energy-efficient advanced oxidation process that can produce reactive species such as hydroxyl radical, reactive chlorine species and ozone. This study investigated the process' ability to detoxify the typical herbicides atrazine and mecoprop (methylchlorophenoxypropionic acid). Both herbicides are resistant to direct solar photolysis or chlorination alone, but they can be degraded by the solar/chlorine process effectively. Atrazine inhibited the development of Arabidopsis thaliana, but such inhibition was negligible after solar/chlorine treatment of an atrazine solution. The transformation of atrazine in the process was shown to be through hydroxylation, hydrogen abstraction and dechlorination but did not involve chlorine substitution or addition. Cl• reacts with atrazine and mecoprop with rate constants of 6.87 × 109 M-1s-1 and 1.08 × 1010 M-1s-1, respectively, while ClO• reacts with mecoprop with a rate constant of 1.11 × 108 M-1s-1. The degradation kinetics of atrazine and mecoprop by solar/chlorine was simulated by modeling, which fitted the experimental results well.