Marksmaclean2018

Conclusions The findings in this review emphasize the need for a more comprehensive and accurate system for diagnosing PJI. In addition, the specific comparison of advantages and drawbacks can be useful for researchers and clinicians with goals of creating new diagnostic tests for PJIs, as well as in clinical scenarios to determine the correct treatment for patients.Objective To observe the seminal plasma proteomic composition in men with spinal cord injury orally treated with probenecid, in order to observe pathways associated with increased sperm motility.Study design Prospective study.Setting Miami Project to Cure Paralysis - University of Miami/Miller School of Medicine.Participants Nine men with spinal cord injury, who agreed to participate in the study.Intervention Oral treatment with probenecid - 500 mg per day for one week, then 500 mg twice daily [1000 mg total] per day for three weeks.Outcome measures Semen analysis as per WHO 2010 guidelines, and seminal plasma proteomics analysis by LC-MS/MS.Results In total, 783 proteins were identified, of which, 17 were decreased, while 6 were increased after treatment. The results suggest a new pathway that could be treated by the decrease of biglycan after probenecid treatment.Conclusion Oral treatment with probenecid is able to alter the seminal plasma proteome, in pathways that explain decreased innate immune response.This article examines whether studying correct versus incorrect examples produces differential learning. A prediction that follows from behaviourism is that learning should be best from studying correct examples. A contrasting prediction is that incorrect examples can highlight a concept's properties that are missing in the example, and thereby enable concept learning. We test these ideas across two experiments, wherein subjects were shown hypothetical study scenarios and were asked to determine whether each was a true experiment. In Experiment 1, some subjects were only presented correct examples, some were only presented incorrect examples, and others were presented both. In addition, example type was crossed with feedback type Some subjects were given explanatory feedback and some were not given any feedback; a control condition was also included, wherein subjects were not shown any study scenarios. All subjects completed a posttest involving novel scenarios; some questions asked subjects to indicate whether they were true experiments (classification questions), and some asked them to specify what was lacking in the design or to indicate how it could be fixed (application questions). Experiment 2 used a similar design, but compared explanatory feedback with corrective feedback. In both experiments, as long as some form of feedback was provided, subjects in the mixed example condition achieved the best classification performance. Furthermore, subjects in the incorrect and mixed example conditions performed best on application questions, particularly when explanatory feedback was provided. These findings offer insights into the mechanisms that might underlie learning from incorrect examples.OBJECTIVE To analyze the patterns of care and survival of cutaneous angiosarcomas of the head and neck. STUDY DESIGN Retrospective cohort study. SETTING National Cancer Database. METHODS The National Cancer Database was queried to select patients with cutaneous angiosarcoma of the head and neck between 2004 and 2015. For survival analysis, patients were included only if they received definitive treatment and complete data. Prognostic factors were analyzed by univariate and multivariable Cox regression. RESULTS We identified 693 patients diagnosed with head and neck angiosarcomas during the study period. The majority were male (n = 489, 70.6%) and elderly (median, 77 years). A total of 421 patients (60.8%) met the criteria for survival analyses. These patients were treated with surgery and radiation (n = 178, 42.3%), surgery alone (n = 138, 32.8%), triple-modality therapy (n = 48, 11.4%), surgery and chemotherapy (n = 29, 6.9%), and chemoradiation (n = 28, 6.7%). With a median follow-up of 29 months, the 3-year survival was 50.1%. Patients undergoing surgery had better median survival than those who did not (38.1 vs 21.0 months, P = .04). Age, comorbidity, tumor size, and surgical margins were significant factors in univariate analyses. On multivariable analysis, age ≥75 years (hazard ratio, 2.65; 95% CI, 1.80-3.88; P less then .001) and positive margins (hazard ratio, 1.91; 95% CI, 1.44-2.51; P less then .001) predicted worse overall survival. CONCLUSION Angiosarcoma of head and neck is a rare malignancy that affects the elderly. Surgical treatment with negative margins is associated with improved survival. Even with curative-intent multimodality treatment, the survival of patients aged ≥75 years is limited.Despite significant progress in recent decades, the recruitment, advancement, and promotion of women in academia remain low. Women represent a large portion of the talent pool in academia, and receive >50% of all PhDs, but this has not yet translated into sustained representation in faculty and leadership positions. Research indicates that women encounter numerous "chutes" that remove them from academia or provide setbacks to promotion at all stages of their careers. These include the perception that women are less competent and their outputs of lesser quality, implicit bias in teaching evaluations and grant funding decisions, and lower citation rates. This review aims to (1) synthesize the "chutes" that impede the careers of women faculty, and (2) provide feasible recommendations, or "ladders" for addressing these issues at all career levels. Enacting policies that function as "ladders" rather than "chutes" for academic women is essential to even the playing field, achieve gender equity, and foster economic, societal, and cultural benefits of academia.Introduction Most patients with asymptomatic carotid stenosis (ACS) now have a lower risk with intensive medical therapy than with stenting (CAS) or endarterectomy (CEA); the annual risk of stroke or death with intensive medical therapy is ~ 0.5%, vs. a periprocedural risk with CAS of ~ 2.5-4.1% with CAS, and ~ 1.4-1.8% with CEA. The excess risk of CAS is greater in older patients.Areas covered Discussed are the need for intensive medical therapy, the nature of intensive medical therapy, approaches to identifying the few patients with ACS who could benefit from CEA or CAS, and which patients would be better suited to CEA vs. 1400W nmr CAS.Expert opinion All patients with ACS are at high risk of cardiovascular events, soshould receive intensive medical therapy including lifestyle modification, intensive lipid-lowering, B vitamins to lower homocysteine (using methylcobalamin rather than cyanocobalamin), and appropriate antithrombotic therapy. High-risk patients who could benefit from intervention can be identified by clinical and imaging features including transcranial Doppler embolus detection, ulceration, intraplaque hemorrhage, reduced cerebrovascular reserve, plaque echolucency, silent infarction on brain imaging, and progression of stenosis.