Marcussenalexander5024

6%), running (0.1%), and climbing stairs (0.7%), with 4.1% in knee straining postures (kneeling and squatting) and 4.3% forward trunk inclination >60°. Workplace observations showed that they carried children 1.8% of the working hours. Conclusions Physical work demands of Danish childcare workers are characterized by about half of the workday being sedentary, and the remaining of the workday being quite evenly distributed between standing and dynamic activities, with low exposures to carrying children. Their exposure to forward bending of the trunk and knee straining postures could impose a risk for MSP and sickness absence, and preventive initiatives should be considered.Objectives Researchers have hypothesized that using Information and Communications Technology (ICT), such as email and social media, may buffer older adults from normative age-graded declines in psychological adjustment. However, past intervention research has been unable to conclusively evaluate this proposition, and no studies to date have examined this topic using naturalistic large-scale longitudinal methods. Methods In this pre-registered study, we examined the co-development between three aspects of psychological adjustment (loneliness, satisfaction with life, and depressiveness) and three factor-analytically derived clusters of ICT use (instrumental, social, and media) using a longitudinal representative sample of 2,922 Dutch adults aged 65 and older that contributed data annually from 2012 to 2017. Results Latent growth curve analyses indicated that ICT use was largely unrelated to psychological adjustment, both cross-sectionally and longitudinally. Of 36 associations tested, three were significant, and only one remained significant after including health and demographic covariates. Specifically, higher levels of media ICT use at baseline predicted steeper declines in satisfaction with life across the study period. Furthermore, results of random-intercept cross-lagged analyses indicated that change in ICT use did not predict future change in psychological adjustment, and vice-versa. Discussion Results of this study help clarify the mixed results of past intervention research, indicating that effects of ICT use on psychological adjustment tend to be either null or much smaller than can be detected using typical intervention sample sizes. Overall, these results suggest that the association between technology use and psychological adjustment is negligible in older adults.Background Neurodegenerative diseases are public health challenges in aging populations. Early identification of people at risk for neurodegeneration might improve targeted treatment. Noninvasive, inexpensive screening tools are lacking but are of great potential. Optical coherence tomography (OCT) measures the thickness of nerve cell layers in the retina, which is an anatomical extension of the brain and might be indicative of common underlying neurodegeneration. We aimed to determine the association of macular ganglion cell-inner plexiform layer (mGCIPL) thickness with cognitive and sensorineural function in midlife. Methods This cross-sectional study included 1880 Beaver Dam Offspring Study participants (aged 27-93 years, mean 58) who participated in the 10-year follow-up examination. read more We assessed cognitive function and impairment, hearing sensitivity thresholds and impairment, central auditory processing, visual impairment and olfactory impairment. We measured mGCIPL using the Cirrus 5000 HD-OCT Macular Cube Scan. Multivariable linear and logistic regression models adjusted for potential confounders were used to determine associations between mGCIPL thickness and cognitive and sensorineural functions, as well as for comparing participants with a thin mGCIPL (1 standard deviation below average) to the remainder in those functions. Results Thinner mGCIPL was associated with worse cognitive function, worse central auditory function and visual impairment. We found an association of mGCIPL thickness with hearing sensitivity in women only and no association with impairment in hearing, olfaction and cognition. Results on the thin group comparisons were consistent. Conclusions MGCIPL thickness is associated with cognitive and sensorineural function and has the potential as a marker for neurodegeneration in middle-aged adults.DNA replication is a complex process that needs to be executed accurately before cell division in order to maintain genome integrity. DNA replication is divided into three main stages initiation, elongation and termination. One of the key events during initiation is the assembly of the replicative helicase at origins of replication, and this mechanism has been very well described over the last decades. In the last six years however, researchers have also focused on deciphering the molecular mechanisms underlying the disassembly of the replicative helicase during termination. Similar to replisome assembly, the mechanism of replisome disassembly is strictly regulated and well conserved throughout evolution, although its complexity increases in higher eukaryotes. While budding yeast rely on just one pathway for replisome disassembly in S phase, higher eukaryotes evolved an additional mitotic pathway over and above the default S phase specific pathway. Moreover, replisome disassembly has been recently found to be a key event prior to the repair of certain DNA lesions, such as under-replicated DNA in mitosis and inter-strand cross-links (ICLs) in S phase. Although replisome disassembly in human cells has not been characterised yet, they possess all of the factors involved in these pathways in model organisms, and de-regulation of many of them are known to contribute to tumorigenesis and other pathological conditions.The use of peripherally inserted central catheters (PICCs) has expanded substantially for drug delivery in clinical practice in recent years. However, PICC lines expose patients to potential complications associated with an increasing incidence of infective endocarditis. We herein report a case of a 57-year-old woman who was diagnosed with tricuspid valve endocarditis by echocardiography. The most probable cause was direct injury to the tricuspid valve by the tip of a PICC line with excessive length in the right heart. The vegetation disappeared with conservative treatment after removal of the PICC line. Clinicians must maintain vigilance against any suspected PICC-related infection in febrile patients with a PICC line. For echocardiographers, precise evaluation of the position of the PICC tip and the detection of endocarditis is important to devise the optimal clinical strategy.