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3° to 0°) and curvature of the back within the thoracic spine (-15.2° to 0°). In addition, >90% of the "activities on the belt" (46% of the daily working routine) were carried out standing.

The activities on the conveyor belt were characterized by a tendency towards hyperextension of the trunk, possibly due to a too high working environment. Furthermore, an increased burden on body structures while standing can be concluded. From a primary prevention perspective, this increased standing load should be reduced by behavioral and relational prevention measures.

The activities on the conveyor belt were characterized by a tendency towards hyperextension of the trunk, possibly due to a too high working environment. Furthermore, an increased burden on body structures while standing can be concluded. From a primary prevention perspective, this increased standing load should be reduced by behavioral and relational prevention measures.

Due to the prevalence and increased demand for manual packaging tasks, the concern for worker health and safety has grown.

This study aims to assess the effects of gender and work postures on subjective discomfort, muscle fatigue, and kinematics during a manual packaging task.

Twenty participants, including 10 males and 10 females, were recruited to perform a 60-minute manual packaging task in sitting and standing postures.

Discomfort was evidenced by increased the rating of perceived exertion (RPE) values (sit from 6 to 14.55; stand from 6 to 17.15) and muscle fatigue was supported by decreased median power frequency (MPF) values for right brachioradialis (RB) (sit -23.68%; stand -16.20%), right upper trapezius (RUT) (sit -20.14%; stand 11.79%), and right erector spinae (RES) (sit 8.64%; stand 11.21%) muscles. Women were more likely to bend forward in a relaxed upper body position, especially while sitting, which may increase the risk of low back pain and women also reported greater discomfort than men, but not in the hands and back. Compared with sitting, the back showed greater muscle fatigue in standing, while muscle fatigue for the shoulders and hands was the opposite.

These findings suggest that work posture should be considered to prevent fatigue in manual packaging tasks. Given the impact of gender on muscle fatigue, work performed by women and men should both be considered. The results can help to develop action strategies and work posture design to prevent musculoskeletal disorders in the manual packaging industry.

These findings suggest that work posture should be considered to prevent fatigue in manual packaging tasks. Given the impact of gender on muscle fatigue, work performed by women and men should both be considered. The results can help to develop action strategies and work posture design to prevent musculoskeletal disorders in the manual packaging industry.

Navigation portable applications have largely grown during the last years. However, the majority of them works just for outdoor positioning and routing, due to their architecture based upon Global Positioning System signals. Real-Time Positioning System intended to provide position estimation inside buildings is known as Indoor Positioning System (IPS).

This paper presents an IPS implemented as a mobile application that can guide patients and visitors throughout a healthcare premise.

The proposed system exploits the geolocation capabilities offered by existing navigation frameworks for determining and displaying the user's position. A hybrid mobile application architecture has been adopted because it allows to deploy the code to multiple platforms, simplifying maintenance and upgrading.

The developed application features two different working modes for on-site and off-site navigation, which offer both the possibility of actual navigation within the hospital, or planning a route from a list of available starting points to the desired target, without being within the navigable area. Tests have been conducted to evaluate the performance and the accuracy of the system.

The proposed application aims to overcome the limitations of Global Navigation Satellite System by using magnetic fingerprinting in combination with sensor fusion simultaneously. This prevents to rely on a single technology, reducing possible system failures and increasing the scalability.

The proposed application aims to overcome the limitations of Global Navigation Satellite System by using magnetic fingerprinting in combination with sensor fusion simultaneously. This prevents to rely on a single technology, reducing possible system failures and increasing the scalability.

Patellar fractures are common intra-articular fractures. Arthroscopically assisted reduction and fixation has been shown to advantageous in the treatment of patellar fractures.

This study aimed to investigate the effect of arthroscopically assisted percutaneous minimally invasive Kirschner wire tension band fixation on the treatment of patellar fractures.

Thirty-four patients with acute closed patellar fractures enrolled in the study and were managed by arthroscopically assisted percutaneous minimally invasive Kirschner wire tension band fixation under epidural anesthesia. Among these patients, 24 were males, and ten were females. The mean age of these patients was 38 ± 0.8 years (range 25-62 years). Of these patients, 20 had transverse fractures, five had longitudinal fractures, four had marginal oblique fractures, and five had multifragmentary upper and lower pole. Fracture causes 25 were caused by falls, and nine were caused by traffic accidents. The time from injury to operation was 6-48 hours, withfective method of management for patellar fractures.

Arthroscopic management of simple patellar fracture with percutaneous minimally invasive Kirschner wire tension band fixation is less invasive than open operation, while still leading to firm fixation, and is conducive to early functional training and functional recovery, and thus is an effective method of management for patellar fractures.

Peak expiratory flow meters (PEFMs) have emerged as primary tools used for diagnosing and monitoring a range of respiratory diseases including asthma and chronic obstructive pulmonary disease, and the performance of these meters will thus impact disease evaluation.

The aim of this study was therefore to assess the technical performance of mechanical and electronic PEFMs commonly used in clinical practice.

The accuracy, repeatability, airflow resistance, frequency response, and linearity of five electronic and seven mechanical PEFMs were measured using a standard flow/volume simulator in accordance with nine A-waveforms and three B-waveforms defined in ISO 237472015 issued by the International Standards Organization (ISO).

The accuracy, repeatability, linearity, airflow resistance, and frequency response pass rates for these 12 different PEFM brands were 41.67%, 75.00%, 50.00%, 75.00%, and 25.00%, respectively. Just 16.67% (2/12) of the tested PEFMs met all evaluated criteria, whereas the remaining PEFMs partially met these criteria. There were no significant differences between the two tested PEFM types in the low flow rate waveform test (P> 0.05), although there were significant differences in the medium and high flow rate waveform test (P< 0.05). In addition, the overall PEFMs test had poor accuracy and good repeatability, although most of the repeatability errors occurred in the BTPS state.

PEFMs commonly used in clinical settings exhibit variable technical performance, and relevant departments need to strengthen PEFM quality control and management in China.

PEFMs commonly used in clinical settings exhibit variable technical performance, and relevant departments need to strengthen PEFM quality control and management in China.We report the case of a 35-week gestation infant girl born by emergent cesarean section for fetal distress in a woman with recent coronavirus disease 2019 (COVID-19). Tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using polymerase chain reaction (PCR) on the infant at 24 and 48 hours of life were negative. However, at 72 hours of life, the infant's respiratory status worsened, and a repeat SARS-CoV-2 PCR was positive. The infant developed leukopenia, thrombocytopenia, and progressive respiratory failure, and died on the ninth day of life. Pathologic examination of the placenta revealed findings consistent with COVID-19 placentitis, and SARS-CoV-2 RNA staining was positive, suggesting intrauterine transmission of the infection.Parkinson's disease (PD) is the second most common neurodegenerative disease, with two main pathological features misfolded α-synuclein protein accumulation and neurodegeneration. Inflammation has recently been identified as a contributor to a cascade of events that may aggravate PD pathology. Inflammasomes, a group of intracellular protein complexes, play an important role in innate immune responses to various diseases, including infection. In PD research, accumulating evidence suggests that α-synuclein aggregations may activate inflammasomes, particularly the nucleotide-binding oligomerization domain-leucine-rich repeat-pyrin domain-containing 3 (NLRP3) type, which exacerbates inflammation in the central nervous system by secreting proinflammatory cytokines like interleukin (IL)-18 and IL-1β. Afterward, activated NLRP3 triggers local microglia and astrocytes to release additional IL-1β. In turn, the activated inflammatory process may contribute to additional α-synuclein aggregation and cell loss. This review summarizes current research evidence on how the NLRP3 inflammasome contributes to PD pathogenesis, as well as potential therapeutic strategies targeting the NLRP3 inflammasome in PD.

Oxidative stress contributes to pathogenesis and progression of Alzheimer's disease (AD). Higher levels of the dietary antioxidants- carotenoids and tocopherols- are associated with better cognitive functions and lower risk for AD, and lower levels of multiple carotenoids are found in serum and plasma of patients with AD. Although brains donated by individuals with mild cognitive impairment had significantly lower levels of lutein and beta-carotene, previous investigators found no significant difference in carotenoid levels of brains with AD and cognitively normal brains.

This study tested the hypothesis that micronutrients are significantly lower in donor brains with AD than in healthy elderly brains.

Samples of donor brains with confirmed AD or verified health were dissected into grey and white matter, extracted with organic solvents and analyzed by HPLC.

AD brains had significantly lower levels of lutein, zeaxanthin, anhydrolutein, retinol, lycopene, and alpha-tocopherol, and significantly increased levels of XMiAD, an unidentified xanthophyll metabolite. this website No meso-zeaxanthin was detected. The overlapping protective roles of xanthophylls, carotenes, α- and γ-tocopherol are discussed.

Brains with AD had substantially lower concentrations of some, but not all, xanthophylls, carotenes, and tocopherols, and several-fold higher concentrations of an unidentified xanthophyll metabolite increased in AD (XMiAD).

Brains with AD had substantially lower concentrations of some, but not all, xanthophylls, carotenes, and tocopherols, and several-fold higher concentrations of an unidentified xanthophyll metabolite increased in AD (XMiAD).