Manningparker0950

Background Perianal infection is a common complication in patients with acute leukemia receiving chemotherapy. It usually manifests as a perianal mass, with redness/swelling, heat, and pain, and can affect physical and mental health in severe cases. The purpose of this study was to investigate the effectiveness of matrine sitz bath (MSB) in treating perianal infection after chemotherapy for acute leukemia. Methods A total of 216 acute leukemia patients with perianal infection that developed during chemotherapy were enrolled in this study and equally randomized into an MSB group and control group. The control group was treated with the conventional potassium permanganate sitz bath. After 14 days of treatment, the clinical efficacy and symptom/sign scores were compared between these 2 groups. The serum levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-10(IL-10), erythrocyte sedimentation rate (ESR), and prostaglandin E2 (PGE2) were detected by using enzyme-linked immunosorbent assay (ELISA). Results The clinical efficacy of MSB group was significantly superior to that of the control group (P less then 0.05). The scores of anal pain, systemic symptoms, mass size, and mass texture were significantly decreased after treatment in both groups (P less then 0.05), and they were significantly lower in the MSB group than in the control group (P less then 0.05). After treatment, the serum levels of hs-CRP, TNF-α, ESR, and PGE2 in these 2 groups significantly dropped (P less then 0.05), and they were significantly lower in the MSB group than in the control group (P less then 0.05); IL-10 level significantly rose in both groups (P less then 0.05), and it was significantly higher in the MSB group than in the control group (P less then 0.05). Conclusions MSB is effective in treating perianal infection after chemotherapy for acute leukemia as it can effectively improve symptoms and signs and alleviate inflammatory reactions.Background Sepsis continues to carry a high rate of mortality, which makes effective and simple evaluation methods for predicting the prognosis of septic patients especially important. In this study, we retrospectively analyzed the relationships between three scoring systems including Sequential Organ Failure Assessment (SOFA) score, Quick SOFA (qSOFA) score, and Logistic Organ Dysfunction System (LODS) score and the prognoses of septic patients. Methods The baseline data, SOFA score, qSOFA score, LODS score, 28-day prognosis, and 90-day prognosis of patients who met the diagnostic criteria of sepsis were retrieved from the Medical Information Mart for Intensive Care III (MIMIC-III) database. Receiver operating characteristic (ROC) curves were drawn for various indicators, and comparisons were drawn between the areas under the ROC curves (AUC) of the different scoring systems. Results The 28-day AUC was 0.661 (0.652, 0.670) for SOFA, 0.558 (0.548, 0.568) for qSOFA, and 0.668 (0.658, 0.677) for LODS; AUC-qSOFA vs. AUC-LODS was 0.103 (0.087, 0.120) (P less then 0.001), and AUC-qSOFA vs. AUC-LODS was 0.110 (0.094, 0.125) (P less then 0.001). The 90-day AUC was 0.630 (0.621, 0.640) for SOFA, 0.551 (0.541, 0.560) for qSOFA, and 0.644 (0.635, 0.653) for LODS; AUC-SOFA vs. AUC-qSOFA was 0.079 (0.065, 0.094) (P less then 0.001), and AUC-qSOFA vs. AUC-LODS was 0.093 (0.079, 0.107) (P less then 0.001). Conclusions SOFA score, qSOFA score, and LODS score can all be used to predict the prognosis of septic patients. LODS score and SOFA score have higher accuracy than qSOFA score; however, qSOFA is simpler to use, making it a more suitable tool in an emergency setting.Background Multiple organ failure complicated by coagulation dysfunction is an important cause of death in patients with sepsis. This study aimed to explore the clinical significance of platelet maximum aggregation rate (MAR) in patients with sepsis and explored the relationship between MAR and prognosis to support treatment decision-making. Methods Blood samples from patients with sepsis (diagnosed according to the 2016 international diagnostic criteria for sepsis 3.0) treated between Sep 2017 and Apr 2018 were assessed. Patients were excluded if they had any other condition or treatment that may have affected platelet function in the previous 2 weeks. A control group of healthy subjects attending the physical examination center in the same period was also included. The MAR was measured using a whole blood platelet function analyzer (PL-12) using a range of different inducers of platelet aggregation, and normal saline. MAR was assessed in the healthy and septic groups, and survivors and non-survivors were compared in the sepsis group 28 days after treatment. Results The MAR in the sepsis group was significantly lower than that seen in the healthy group (P less then 0.05 for all inducers). The MAR of patients with sepsis was negatively correlated with their Sequential Organ Failure Assessment (SOFA) scores. In the sepsis group, the MAR of non-survivors was significantly lower than that of the survivors (P less then 0.05 for all inducers). Conclusions The platelet MAR was significantly decreased in patients with sepsis and in non-survivors. These data may support treatment decision-making in patients with sepsis.An efficient and benign iron-catalyzed room-temperature method was developed for direct sequential C(sp3)-H/N-H annulation to construct pyrroloindole scaffolds. This strategy features cheap and readily available raw materials and mild room-temperature reaction conditions and provides a green and practical method for the one-pot rapid synthesis of a wide range of diversely functionalized pyrrolo[1,2-α]indoles.Water condensation plays a major role in a wide range of industrial applications. Over the past few years, many studies have shown interest in designing surfaces with enhanced water condensation and removal properties. It is well known that heterogeneous nucleation outperforms homogeneous nucleation in the condensation process. Because heterogeneous nucleation initiates on a surface at a small scale, it is highly desirable to characterize water-surface interactions at the molecular level. Molecular dynamics (MD) simulations can provide direct insight into heterogeneous nucleation and advance surface designs. Existing MD simulations of water condensation on surfaces were conducted by tuning the solid-water van der Waals interaction energy as a substitute for modeling surfaces with different wettabilities. However, this approach cannot reflect the real intermolecular interactions between the surface and water molecules. Here, we report MD simulations of water condensation on realistic surfaces of alkanethiol self-assembled monolayers with different head group chemistries. We show that decreasing surface hydrophobicity significantly increases the electrostatic forces between water molecules and the surface, thus increasing the water condensation rate. We observe a strong correlation between our rate of condensation results and the results from other surface characterization metrics, such as the interfacial thermal conductance, contact angle, and the molecular-scale wettability metric of Garde and co-workers. This work provides insight into the water condensation process at the molecular scale on surfaces with tunable wettability.Methylene blue (MB) is widely used as a photosensitizer in photodynamic therapy applications. However, it is easily reduced by reductases in biological environments, which hampers its further applications. Here, we developed a one-pot method to synthesize MB-encapsulated and poly(vinylpyrrolidone) (PVP)-modified zeolitic imidazolate framework-90 (ZIF-90) nanoparticles (MB@ZIF-90/PVP NPs). The NPs show intact crystalline structure with improved colloidal dispersity and stability both in water and in the medium for cell culture. The size of the enzymes is much larger than the pore size of ZIF-9; thus, the access of reductive enzymes to encapsulated MB is prohibited, resulting in the protection of MB's photodynamic activity. Furthermore, cell experiments confirm that MB@ZIF-90/PVP NPs have lower dark cytotoxity than equivalent free MB but can efficiently induce photodynamic damage to tumor cells even in the presence of reductive enzymes upon light irradiation.Using ab initio electronic structure methods with flexible atomic orbital basis sets, we examined the nature of the bonding arising from donation of an ns2 electron pair on an alkaline earth atom (Mg or Ca) into a vacant n'p orbital on the group 13 atom of BH3, AlH3, or GaH3. We also examined what happens when an excess electron is attached to form corresponding molecular anions. Although the geometries of MgBH3, MgAlH3, MgGaH3, and CaBH3 are found to be much as one would expect for datively bound molecules, CaAlH3 and CaGaH3 were found to have very unusual geometries in that their Al-H or Ga-H bonds are directed toward the Ca atom rather than away, as in the other compounds. Internal electrostatic Coulomb attractions between the partially positively charged Ca center and the partially negatively charged H centers were suggested as a source of these unusual geometries. The other novel finding is that the electron affinities (EAs) of all six M'-MH3 species lie in the 0.7-1.0 eV range, which is suggestive of ionic electronic structures for the neutrals even though the partial charges on the alkaline earth centers are as low as 0.3 atomic units. Partial positive charge on the alkaline earth atoms combined with substantial electron affinities of the BH3, AlH3, and GaH3 groups, but only when distorted from planar geometries, were suggested to be the primary contributors to the large EAs.Plant seed germination involving dynamic water uptakes and biochemical changes is essential for preservation of plant germplasm resource and worldwide food supply. To understand the germination-associated compartmental biochemistry changes, we quantitatively analyzed the metabolite composition (metabonome) for embryonic axes, cotyledons, and testae of mung bean (Vigna radiata) seeds in three germination phases using the NMR-based metabonomics approach. We found that three structures of mung bean seeds had distinct metabonomic phenotypes dominated by 53 metabolites including amino acids, carbohydrates, organic acids, choline metabolites, nucleotides/nucleosides, and shikimate-mediated secondary metabolites together with calcium and magnesium cations. During germination, all three seed structures had outstanding but distinct metabonomic changes. Both embryonic axis and cotyledon showed remarkable metabolic changes related to degradation of carbohydrates and proteins, metabolism of amino acids, nucleotides/nucleosides, and choline together with energy metabolism and shikimate-mediated plant secondary metabolism. The metabonomic changes in these two structures were mostly related to multiple functions for biochemical activities in the former and nutrient mobilizations in the latter. In contrast, testa metabonomic changes mainly reflected the metabolite leakages from the other two structures. Phase 1 of germination was featured with degradation of oligosaccharides and proteins and recycling of stored nucleic acids together with anaerobic metabolisms, whereas phase 2 was dominated by energy metabolism, biosynthesis of osmolytes, and plant secondary metabolites. These provided essential metabolic information for understanding the biochemistry associated with early events of seed germination and possible metabolic functions of different seed structures for plant development.A molecular beam of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) is focused by a hexapolar electrostatic field and photolyzed by UV laser radiation at 234 nm. Angular and speed distributions of chlorine and bromine photofragments emitted from halothane are measured for both spin-orbit states independently. Although the dissociation energy of the C-Cl bond is larger than that of C-Br, the relative yield of Cl to Br was found to be approximately 2. Measured speed and angular distributions of atomic fragments show distinct kinetic energy release and scattering characteristics for bromine, observed fast and aligned fragments exhibit a signature of a direct mode of dissociation for the C-Br bond, via the electronically excited potential energy surface denoted nσ*(C-Br), of repulsive nature; for chlorine, a variation in the features is observed for the dissociation pathway through nσ*(C-Cl), from a modality similar to the bromine case, leading to fragments with appreciable kinetic energy release and pronounced directionality, to a modality involving slow products, nearly isotopically distributed. The origin of this behavior can be attributed to nonadiabatic interaction operating between the nσ*(C-Br) and nσ*(C-Cl) surfaces. These results are not only relevant for a detailed understanding of adiabatic versus diabatic coupling mechanisms in the manifold of excited states populated by photon absorption, but they also point out the possibility of selectively inducing specific dissociation pathways, even when involving energetically unfavorable outcomes, such as, in this case, the prevailing rupture of the stronger C-Cl bond against that of the weaker C-Br bond.Nanoporous graphene displays salt-dependent ion permeation. In this work, we investigate the differences in Donnan potentials arising between reservoirs, separated by a perforated graphene membrane, containing different cations. We compare the case of monovalent cations interacting with nanoporous graphene with the case of bivalent cations. This is accomplished through both measurements of membrane potential arising between two salt reservoirs at different concentrations involving a single cation (ionic potential) and between two reservoirs containing different cations at the same concentration (bi-ionic potential). In our present study, Donnan dialysis experiments involve bivalent MgCl2, CaCl2, and CuCl2 as well as monovalent KCl and NH4Cl salts. For all salts, except CuCl2, clear Donnan and diffusion potential plateaus were observed at low and high salt concentrations, respectively. Our observations show that the membrane potential scaled to the Nernst potential for bivalent cations has a lower value (≈50%) than for monovalent cations (≈72%) in the Donnan exclusion regime. This is likely due to the adsorption of these bivalent cations on monolayer graphene. For bivalent cations, the diffusion regime is reached at a lower ionic strength compared to the monovalent cations. For Mg2+ and Ca2+, the membrane potential does not seem to depend upon the type of ions in the entire ionic strength range. A similar behavior is observed for the KCl and NH4Cl membrane potential curves. For CuCl2, the membrane potential curve is shifted toward lower ionic strength compared to the other two bivalent salts and the Donnan plateau is not observed at the lowest ionic strength. Bi-ionic potential measurements give further insight into the strength of specific interactions, allowing for the estimation of the relative ionic selectivities of different cations based on comparing their bi-ionic potentials. This effect of possible ion adsorption on graphene can be removed through ion exchange with monovalent salts.Singlet fission (SF) is a spin-allowed carrier multiplication process that has potential to overcome the Shockley-Queisser limit of solar energy conversion efficiency for single-junction solar cells. It is of importance to prescreen appropriate SF candidates for both basic research and practical applications of SF. Besides common polycyclic aromatic hydrocarbons (PAHs), diketopyrrolopyrrole (DPP) derivatives also undergo efficient SF. A series of DPP derivatives with fused aromatic substituents were investigated considering their conjugation length, constitution, and the introduction of terminal substituents. A comparison of SF properties between nonfused and fused aromatic-substituted DPP derivatives was carried out. Detailed analysis focused on elucidating the relationship between the frontier molecular orbital energies, multiple diradical characters, and SF-relevant excited-state energy levels. Compared to nonfused aromatic-substituted DPP derivatives, fused aromatic-substituted DPP derivatives which contain three aromatic units (thiophene or furan) still share more appropriate energy levels for SF sensitizers. Changing the five-membered aromatic units with benzene ring and introducing -F, -OMe, and -COOH as terminal substituents are both effective ways to improve their performance as SF sensitizers. The results of this research help us to understand the SF properties of DPP derivatives deeply and are beneficial for the design of new DPP-based SF sensitizers.The proteasome is a key protease in the eukaryotic cells which is responsible for various important cellular processes such as the control of the cell cycle, immune responses, protein homeostasis, inflammation, apoptosis, and the response to proteotoxic stress. Acting as a major molecular machine for protein degradation, proteasome first identifies damaged or obsolete regulatory proteins by attaching ubiquitin chains and subsequently utilizes conserved pore loops of the heterohexameric ring of AAA+ (ATPases associated with diverse cellular activities) to pull and mechanically unfold and translocate the misfolded protein to the active site for proteolysis. A detailed knowledge of the reaction mechanism for this proteasomal proteolysis is of central importance, both for fundamental understanding and for drug discovery. The present study investigates the mechanism of the proteolysis by the proteasome with full consideration of the protein's flexibility and its impact on the reaction free energy. Major attention is paid to the role of the protein electrostatics in determining the activation barriers. The reaction mechanism is studied by considering a small artificial fluorogenic peptide substrate (Suc-LLVY-AMC) and evaluating the activation barriers and reaction free energies for the acylation and deacylation steps, by using the empirical valence bond method. Our results shed light on the proteolysis mechanism and thus should be important for further studies of the proteasome action.Polar surfaces of ionic crystals are of growing technological importance, with implications for the efficiency of photocatalysts, gas sensors, and electronic devices. The creation of ionic nanocrystals with high percentages of polar surfaces is an option for improving their efficiency in the aforementioned applications but is hard to accomplish because they are less thermodynamically stable and prone to vanish during the growth process. Herein, we develop a strategy that is capable of producing polar surface-dominated II-VI semiconductor nanocrystals, including ZnS and CdS, from copper sulfide hexagonal nanoplates through cation exchange reactions. The obtained wurtzite ZnS hexagonal nanoplates have dominant 002 polar surfaces, occupying up to 97.8% of all surfaces. Density functional theory calculations reveal the polar surfaces can be stabilized by a charge transfer of 0.25 eV/formula from the anion-terminated surface to the cation-terminated surface, which also explains the presence of polar surfaces in the initial Cu1.75S hexagonal nanoplates with cation deficiency prior to cation exchange reactions. Experimental results showed that the HER activity could be boosted by the surface polarization of polar surface-dominated ZnS hexagonal nanoplates. We anticipate this strategy is general and could be used with other systems to prepare nanocrystals with dominant polar surfaces. Furthermore, the availability of colloidal semiconductor nanocrystals with dominant polar surfaces produced through this strategy opens a new avenue for improving their efficiency in catalysis, photocatalysis, gas sensing, and other applications.Application of aroma extract dilution analysis and headspace aroma dilution analysis revealed 51 odorants in raw green Toona sinensis and 54 odorants in raw red T. sinensis in the flavor dilution factor range of 8-4096. (E,E)-2,4-Decadienal, nonanal, 2,3,5-trimethylpyrazine, (E,Z)- and (Z,Z)-di-1-propenyl trisulfide, 2-methoxyphenol, and 4-ethylphenol were first identified as key odorants of T. sinensis. Clear differences between green and red T. sinensis in aroma profiles, flavor dilution factors, quantitative data, and odor activity values verified that (E,E)-, (E,Z)-, and (Z,Z)-di-1-propenyl disulfide, (E,E)-, (E,Z)- and (Z,Z)-di-1-propenyl trisulfide, cis- and trans-2-mercapto-3,4-dimethyl-2,3-dihydrothiophene, and dimethyl sulfide caused the distinct sulfury odor note of each variety. Further, hexanal, (E)-2-hexenal, (E)-2-hexen-1-ol, and (E,Z)-2,6-nonadienal led to the green odor note in green T. sinensis, while 2-methoxyphenol and 4-ethylphenol contributed to the intense phenolic aroma note in red T. sinensis. Quantitation experiments and triangle tests in blanched T. sinensis verified that the quick loss of the abovementioned sulfur-containing compounds, aldehydes, the alcohol (E)-2-hexen-1-ol, and phenols was responsible for the changes in the overall aroma profile during blanching.This research introduces a method to directly detect serotonin in a single platelet through single-entity electrochemistry. Platelets isolated from human blood were analyzed by cyclic voltammetry and current-time measurements. When a single platelet collides with an ultramicroelectrode, serotonin inside the platelet is oxidized at the electrode surface, and an anodic current peak is consequently observed during measurement. The concentration of serotonin can be determined by integrating this peak current. In addition, this method can be used to determine the platelet concentration. Analysis of the collision frequency of platelets can provide information about the platelet concentration in the blood. As a result, platelet levels and serotonin concentrations in single platelets can be measured quickly and easily.A defect dynamic model is proposed for the positive synergistic effect of neutron- and γ-ray-irradiated silicon NPN transistors. The model considers a γ-ray-induced transformation and annihilation of the neutron-induced divacancy defects in the p-type base region of the transistor. The derived model of the base current predicts a growth function of the γ-ray dose that approaches exponentially an asymptotic value, which depends linearly on the neutron-induced initial displacement damage (DD) and a linear decay function of the dose whose slope depends quadratically on the initial DD. Variable fluence and dose neutron-γ-ray irradiation experiments are carried out, and we find all of the novel dose and fluence dependence predicted by the proposed model are confirmed by the measured data. Our work, hence, identifies that the defect evolution under γ-ray irradiation, rather than the widely believed interface Coulomb interaction, is the dominating mechanism of the synergistic effect. Our work also paves the way for the modification of displacement defects in silicon by γ-ray irradiation.Aptasensors are biosensors that include aptamers for detecting a target of interest. We engineered signaling aptasensors for the detection of RNA hairpins from the previously described malachite green (MG) RNA aptamer. The top part of this imperfect hairpin aptamer was modified in such a way that it can engage loop-loop (so-called kissing) interactions with RNA hairpins displaying partly complementary apical loops. These newly derived oligonucleotides named malaswitches bind their cognate fluorogenic ligand (MG) exclusively when RNA-RNA kissing complexes are formed, whereas MG does not bind to malaswitches alone. Consequently, the formation of the ternary target RNA-malaswitch RNA-MG complex results in fluorescence emission, and malaswitches constitute sensors for detecting RNA hairpins. Malaswitches were designed that specifically detect precursors of microRNAs let7b and miR-206.A miniature laser-induced fluorescence (mLIF) detector utilizing a novel spherical dichroic reflector (SDR), an unconventional long working distance high magnification objective, an uncommon broadband emission-matched excitation filter pair, and a silicon-based photodiode detector assembly instead of a photomultiplier tube was developed and evaluated. The detection cell was placed at the spherical center of the SDR instead of the regular focus, yielding a 1.8× signal-to-noise ratio (SNR) improvement. Different from previous works, the use of a 40× objective with a long working distance of 5.38 mm and a broadband BP 527-70 nm emission filter with matched BP 450-30 nm excitation filter improved SNR to 4.6× and 1.9×, respectively. By flow injection analysis (FIA) evaluation, the limit of detection (LOD; 3σ method) for fluorescein sodium was 1.5 × 10-13 M or 8.9 fluorescein molecules in 98 pL detection volume, which was the lowest level of LIFs evaluated by FIA mode. The analysis of three kinds of amino acids with LODs at sub pM to fM level (the lowest levels, hundreds of times lower than previous works using normal capillary) demonstrated the potential of the mLIF in ultratrace analysis of biological and environmental samples, including low copy molecules in a single cell.Designing efficient metal nitride electrocatalysts with advantageous nanostructures toward overall water splitting is of great significance for energy conversion. In this work, holey cobalt-iron nitride nanosheet arrays grown on Ni foam substrate (CoFeNx HNAs/NF) are prepared via a facile hydrothermal and subsequent thermal nitridation method. This unique HNA architecture can not only expose abundant active sites but also facilitate the charge/mass transfer. Resulting from these merits, the CoFeNx HNAs/NF exhibits high catalytic performance with overpotentials of 200 and 260 mV at 10 mA cm-2 for the hydrogen evolution reaction (HER) and 50 mA cm-2 for the oxygen evolution reaction (OER), respectively. Furthermore, when using CoFeNx-500 HNAs/NF as both anode and cathode, the alkaline electrolyzer could afford a current density of 10 mA cm-2 at 1.592 V, higher than many other metal nitride-based electrocatalysts. This work signifies a simple approach to prepare holey metal nitride nanosheet arrays, which can be applied in various fields of energy conversion and storage.Organic nonvolatile memory with ultralow power consumption is a critical research demand for next-generation memory applications. However, obtaining a large-area, highly oriented ferroelectric ultrathin film with low leakage current and stable ferroelectric switching remains a challenge for achieving low operation voltage in ferroelectric memory transistors. Here, an ideal ferroelectric neat PVDF ultrathin film with a high degree of orientation is fabricated by a melt-draw technique without post-thermal treatment and assisted stabilization process. The PVDF ultrathin film is self-polarized with predominantly vertical orientation of dipole moments, exhibiting a d33 of 25 pm V-1 and the ultralow coercive voltage of approximately 3 V characterized by piezoresponse force microscopy. A remnant polarization of 6.3 μC cm-2 is identified based on a PVDF capacitor with an active layer formed by six layers of melt-drawn thin films. By employing a single-layer melt-drawn PVDF ultrathin film as an insulation layer, a bottom-gate-top-contact ferroelectric field-effect transistor is fabricated with a very low operation voltage of 5 V. It exhibits a memory window with an on/off current ratio of 103 at zero gate bias and threshold voltage shift of around 2 V.Flexible pressure sensors emerge for important applications in wearable electronics, with increasing requirements for high sensitivity, fast response, and low detection limit. However, there is still a challenge in this field, that is, how to maximize both the electrical performance and mechanical stretchability simultaneously. Here, we report a straightforward and cost-effective method to fabricate highly stretchable and sensitive capacitive pressure sensor arrays. It features a unique design of integrating the icicle-shaped liquid metal film electrode and reliable processing of the liquid metal and elastomer. Under an external load, the deformation of the elastic bump structure dramatically results in an increase in the overlapping area of the electrodes and a decrease in the separation distance, offering a new capacitive sensing scheme with an enhanced sensitivity. Our sensor has been demonstrated with a high sensitivity of 39% kPa-1 in the range of 0-1 kPa, limit of detection as low as 12 Pa, hysteresis error of 8.46% at a maximum pressure of 25 kPa, and stretchability up to 94% strain without any failure. The arrayed sensor has been successfully applied to force measurements on a curved surface, contour mapping of external loads, and monitoring of contact pressures under various cervical postures.In air filtration, for creating healthy indoor air, there is an intrinsic conflict between high filtration efficiency and low wind pressure drop. In this study, we overcame this conflict by developing new dielectric heterocaking (HC) filters, in which high relative dielectric constant (εr) materials were heterogeneously loaded on traditional polymer fibers. The dielectric HC filters in an electrostatic polarizing field generate a great amount of charges on their surface, leading to a strong attraction to precharged aerosol particles, and result in high filtration efficiency. Observing via a charged coupled device camera, the migration speed of aerosol smoke particles toward the polarized HC fiber exceeded those toward the unpolarized HC fiber by a factor of 6. We loaded high-εr HCs including manganese dioxide (MnO2), activated carbon, zinc oxide (ZnO), copper oxide (CuO), and barium titanate (BaTiO3) on polyurethane foams using a fast and large-scale roll-to-roll gel squeezing method. Based on the experimental results, when HCs had a εr larger than 5.1, an increased εr did not benefit electrostatic filtration efficiency for aerosol particles much, but resulted in a larger net ozone production. We suggested a MnO2-HC filter for efficient and multifunctional filtration of indoor particles, ambient ozone, and formaldehyde with only 3.8 Pa pressure drop at 1.1 m/s filtration velocity. This efficient and cost-effective dielectric HC filter opens a new avenue for the design of multifunctional filters, which will facilitate its large-scale production and commercial application in the ventilation system for healthy buildings.The enduring epidemic outbreak which started in Wuhan city of China, in December 2019 caused by the 2019 novel coronavirus (COVID- 19) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a dangerous and deadly Public Health disaster of International apprehension, with cases confirmed in several countries. This novel community health trouble is frightening the universe with clinical, psychological, emotional, collapse of health system and economical slowdown in each and every part of the world infecting nearly 200 countries. A highly virulent and pathogenic COVID-19 viral infection with incubation period ranging from two to fourteen days, transmitted by breathing of infected droplets or contact with infected droplets, belongs to the genus Coronavirus with its high mutation rate in the Coronaviridae. The likely probable primary reservoir could be bats, because genomic analysis discovered that SARSCoV-2 is phylogenetically interrelated to SARS-like bat viruses. The transitional resource of origin and transfer to humans is not known, however, the rapidly developing pandemic has confirmed human to human transfer. Approximately 1,016,128 reported cases, 211,615 recovered cases and 53,069 deaths of COVID-2019 have been reported to date (April 2, 2020). The symptoms vary from asymptomatic, low grade pyrexia, dry cough, sore throat, breathlessness, tiredness, body aches, fatigue, myalgia, nausea, vomiting, diarrhea, to severe consolidation and pneumonia, acute respiratory distress syndrome (ARDS) and multiple organ dysfunction leading to death with case fatality rate ranging from 2 to 3%.In this ongoing SARS-CoV2 Corona virus pandemic, we are witnessing an uninhibited spread of mis-information on various social media platforms. This spread of mis-information or "mis-infodemic" is playing a negative role in our fight against the virus with far reaching consequences. International organizations like the WHO and other governmental organizations have geared up to the occasion to limit the spread of these and bring clarity in this context. In this time of crisis, risk communication is vital in the communication between organizations/government and the people. But apart from the organizations, the onus is on the people and media to realise the importance and verify the authenticity of information being circulated. It is imperative that information, being a double edged sword, is handled with caution and effective communication strategies are devised for the dissemination of accurate and scientific health related information. Social media can be used in a constructive way in mitigating the effects of this pandemic for the betterment of the society.The treatment of delirium or psychosis in patients with Parkinson's disease (PD) can be complicated by the limited number of pharmacological agents that can be used in this population. Typical and atypical antipsychotics are contraindicated, as they can worsen motor symptoms. The treatment of acute delirium is even more complicated in the hospital setting, as many medications deemed safer in this population are only available in oral form. We present a case of acute delirium in a patient with PD, likely precipitated by a polypharmacy interaction of new medications, that was successfully managed by transferring the patient to the intensive care unit and administering dexmedetomidine for 72 hours.Objective Cognitive symptoms of Parkinson's disease (PD) may be alleviated by moderate-to-vigorous physical activity (MVPA), but no published research has characterized the relationship between objectively measured sedentary behavior and cognitive symptoms of PD. Therefore, the objective of this study was to assess the cross-sectional relationship between sedentary time and cognitive performance in a small pilot sample of individuals with mild-to-moderate PD. Methods Objective measures of sedentary time were obtained using an armband accelerometer. Cognition was assessed with the Parkinson's Disease Cognitive Rating Scale and a computerized task-switching paradigm. Results The percentage of awake time spent in sedentary activities was negatively correlated with attention (β = -14.20, t(12) = -2.47, p = 0.03) but not other cognitive domains (p > 0.05) after controlling for MVPA and medication dosage. Conclusion Sedentary activity may have unique associations with cognition, particularly attention, over and above MVPA in individuals with PD.Objective We aimed to identify risk factors for falls in patients with de novo Parkinson's disease (PD). Methods Forty-six patients with de novo PD were retrospectively included in the study. We assessed details on the patients' motor symptoms as well as non-motor symptoms using several representative scales for global cognition, depression, fatigue, and dysautonomia. Fallers and non-fallers were identified according to their history of falls during the preceding year. Results Twenty-two patients (45.8%) with de novo PD had a history of falls. Compared with the non-faller group, the faller group exhibited higher scores for postural instability/gait difficulty (PIGD), anxiety, fatigue, total dysautonomia, gastrointestinal dysfunction, and thermoregulatory dysfunction. Moreover, logistic regression analysis showed that falling was positively correlated with anxiety and gastrointestinal symptoms but negatively associated with the tremor scores. Conclusion Our findings suggest that falling in patients with de novo PD is significantly associated with PIGD/non-tremor symptoms, anxiety, and gastrointestinal dysfunction.Objective The long-term effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on postural instability and gait difficulty (PIGD) in patients with Parkinson's disease (PD) remain unclear. In this study, we aimed to evaluate the longterm effects of STN-DBS surgery on PIGD symptoms in patients with advanced-stage PD. Methods This study included 49 consecutively included patients with PD who underwent bilateral STN-DBS. The Unified Parkinson's Disease Rating Scale (UPDRS) scores and subscores for PIGD were assessed at baseline and at 1, 3, and 5 years postoperatively. The PIGD subscore was divided into PIGD-motor and PIGD-activities of daily living (ADL) scores according to parts III and II of the UPDRS, respectively. Results The PIGD-motor and PIGD-ADL scores at the "medication-off" state improved at 3 and 5 years, respectively. Overall, the UPDRS III and II scores at "medication-off" improved at 5 years. The UPDRS IV score also significantly improved and the levodopa equivalent daily dosage decreased at all follow-ups. Finally, the PIGD-motor score at baseline was able to predict long-term improvement in the PIGD-motor score at the 5-year follow-up. Conclusion The STN-DBS has both short- and long-term effects on PIGD, as well as overall motor function, in patients with advanced PD. The degree of PIGD at the preoperative evaluation can be used to predict long-term outcomes after STN-DBS surgery.The etiology of Parkinson's disease (PD) is not fully understood, but environmental toxin overexposure, increased intestinal permeability, and dysbiosis related to nutrition and lifestyle habits are thought to be contributors. Considering these nutrition and lifestyle implications, there is a lack of practice-based programs utilizing interventions for managing symptoms or slowing the progression of the disease. The purpose of this narrative review was to identify relevant research related to nutrition and lifestyle interventions for PD, evaluate the research utilizing the evidence analysis process of the Academy of Nutrition and Dietetics to assess the quality of each research article, and group the research into categories. A grading of recommendations assessment, development and evaluation (GRADE) of either good, fair, limited, or not assignable was allocated to each category of research, including diet patterns, vitamin D, B-complex, omega-3 fatty acids, coenzyme Q10, probiotics, physical activity, stress, and sleep. An intervention based on the research presented in the review may be utilized for coaching people with PD on symptom management.Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects 1-2% of people by the age of 70 years. Age is the most important risk factor, and most cases are sporadic without any known environmental or genetic causes. Since the late 1990s, mutations in the genes SNCA, PRKN, LRRK2, PINK1, DJ-1, VPS35, and GBA have been shown to be important risk factors for PD. In addition, common variants with small effect sizes are now recognized to modulate the risk for PD. Most studies in genetic PD have focused on finding new genes, but few have studied the long-term outcome of patients with the specific genetic PD forms. Patients with known genetic PD have now been followed for more than 20 years, and we see that they may have distinct and different prognoses. New therapeutic possibilities are emerging based on the genetic cause underlying the disease. Future medication may be based on the pathophysiology individualized to the patient's genetic background. The challenge is to find the biological consequences of different genetic variants. In this review, the clinical patterns and long-term prognoses of the most common genetic PD variants are presented.COVID-19 is a Public Health Emergency of International Concern (PHEIC). Direct economic loss is expected to be much more than that of SARS outbreak in 2003. The risk factors of COVID-19 epidemic at the early stage incluede the misjudgment of the epidemic, delay in reporting this emerging infectious disease, nosocomial infection-caused transmission of the virus into local communities, and weak public health interventions. The infection rate (or the incidence) reflects the prophylactic effect in population. Case fatality reflects the therapeutic effect of clinical intervention. There were sufficient medical resources at the national top levels accumulated in Wuhan. Furthermore, medical professionals and sufficient medical supplies from other provinces have been assigned to join in the fighting against the epidemic in Wuhan. However, the case fatality in Wuhan has being kept the highest in China, indicating that clinical treatment for this virus-caused emerging infectious disease, whose pathogenesis remains to bas the health section of the governments' public services by the law, must be greatly improved to meet the increasing health needs of the publics. Second, the vicious circle of profit-seeking-caused "attaching importance to clinical treatment and despising disease prophylaxis" should be immediately broken to optimize the national health service system in China by increasing the investment in public health service.Background Exercise is considered an effective intervention to relieve chronic back pain. However, it is still unknown whether specific exercise patterns vary in terms of their efficiency and effectiveness. Aim To investigate the differential health and economic effects of intensity, specificity and degree of subjective perceived physical exertion across five exercise patterns (endurance, gymnastics, fitness, back gymnastics, multimodal back exercise) in adults with back pain. Design Longitudinal observational cohort study over a period of 24 months. Setting Various non-therapeutic exercise facilities (e.g., outdoor, fitness centres, health insurance programmes, sports clubs) across one federal state of Germany (Baden- Wuerttemberg). Population Adults with back pain (N = 2,542, Mean = 46.9 years, 66% females, Graded Chronic Back pain GCPS 1= 40.5%, GCPS 2= 27.3 %, GCPS 3= 20.7 %, GCPS 4= 11.5 %). Methods Self-reported back pain (functional restrictions and pain = Back Pain Function Score, BPFS) and characterioderate to high intensities without maximum perceived exertion is effective and efficient in reducing back pain.Background Interscalene brachial plexus block (ISBPB) is commonly used with general anesthesia for postoperative pain management in shoulder surgery. This study investigated the incidence of hypothermia and changes in the body temperature in patients undergoing arthroscopic shoulder surgery under ISBPB with propofol sedation. Methods This retrospective study enrolled 220 patients who underwent arthroscopic shoulder surgery. Patients were divided into general anesthesia (n = 34) and ISBPB with propofol sedation (n = 186) groups, and medical records were retrospectively compared. In addition, patients from the ISBPB group were further divided according to age (elderly, [≥ 65 years]; n = 98 vs. young, [ less then 65 years]; n = 88), and their data were compared. Results Twenty-seven patients (12.3%) experienced perioperative hypothermia (range; 35.3-35.9℃). The incidence of perioperative hypothermia was 29.4% and 9.1% in the general anesthesia and ISBPB groups, respectively, and there was a significant difference between the two groups (P = 0.002). The incidence of perioperative hypothermia according to age in the ISBPB group was 9.2% and 9.1% in the elderly and young groups, respectively, and there was no significant difference between the two groups (P = 0.983). Conclusions The incidence of perioperative hypothermia during arthroscopic shoulder surgery under ISBPB with propofol sedation is lower than that under general anesthesia. Furthermore, when using ISBPB with propofol sedation, the incidence of perioperative hypothermia in elderly patients is similar to that in younger patients.Background Since the Coronavirus diseases-19 (COVID-19) was reported in Wuhan, China, Korea has also been exposed to the virus. In Korea, COVID-19 screening guidelines have been established in each hospital, trying to prevent the spread of infection. A case of successful Cesarean section from confirmed mother has been reported, but there are no guidelines for suspected mothers. Cesarean section can be operated urgently without sufficient evaluations of the infection. Case Our hospital, located in Daegu, Korea, was designated as quarantine and delivery facility for suspected mother, and Cesarean section was done to seven suspected mothers and one confirmed mother. Conclusions This case report suggests the guideline for infection control of surgery and anesthesia in emergent cesarean section of COVID-19 suspected mother by preparing operating room and protection strategy.Background Neuroleukemiosis is a rare complication of leukemia. The diagnosis may be delayed owing to non-specific symptoms and the need for special diagnostic modalities. Case A 70-year-old man in his sixth year of remission from acute myeloid leukemia was referred to the pain clinic for shooting and radiating pain in the left posterior leg. A lumbar spine magnetic resonance imaging showed mild disc bulging of the L2-3, which was insufficient to explain the patient's symptoms. With insufficient pain response to lumbar epidural block and piriformis injection, we examined both sciatic nerves using an ultrasound and identified an enlarged hypoechoic mass on the left sciatic nerve at mid-thigh level. After that, We biopsied the mass under general anesthesia, and histology confirmed it to be neuroleukemiosis. Conclusions Ultrasound is an inexpensive, non-invasive, simple, and quick diagnostic modality that can be used as a screening tool in the diagnosis of neuroleukemiosis.Objective To analyze the prognosis factors of cerebrospinal fluid (CSF) spread after surgery in glioblastoma (GBM) patients when tumors progressed and the effect factors on prognosis. Methods A retrospective study was conducted on 124 patients who were pathologically diagnosed as glioblastoma after surgery, and found tumor progressed during regularly follow-up at Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University between January 2009 and August 2017.There were 82 males and 42 females, aged 47.9 years(range 19 to 75 years) .Patients were divided into local recurrence group(96 cases) and CSF spread group (28 cases) .Clinical data were recorded in detail and compared by independent sample t test or χ(2) test.Kaplan-Meier survival curves was used to demonstrated the distribution of progression free survival (PFS) overall survival (OS) and post progression survival (PPS), and differences between local recurrence and CSF spread groups were assessed by Log-rank test.Cox proportion hazard regression analysis was used to identify independent prognostic factors. Results Logistics regression analysis showed ventricle entry was the only prognosis factor of CSF spread (OR=2.667, 95% CI 1.128 to 6.304, P=0.025).No significant distinction was observed in PFS between CSF spread group and local recurrence group(7.0 months vs.9.3 months, P=0.066).However, OS and PPS were substantially shortened in CSF spread group (13.0 months vs.23.0 months, P=0.011; 6.0 months vs.11.0 months, P=0.022, respectively).Mutations of isocitrate dehydrogenase gene, distant spread, gross-total resection, Ki-67 index>30% were independent prognostic factors of GBM patients. Conclusions Ventricle entry is a prognosis factor for CSF spread, after which the median OS and PPS are markedly diminished.However, ventricle entry is not independent prognosis factor shortening survival.Objective To investigate the diagnose value of D-dimer for chronic periprosthetic infection (PJI) after hip and knee arthroplasty. Methods A retrospective analyze was conducted on 168 patients underwent revision arthroplasty and primary arthroplasty at the First Affiliated Hospital of Xinjiang Medical University from November 2017 to December 2018.There were 58 males and 110 females, aged(58.6±14.5)years.There were 48 cases of chronic PJI (21 cases of knee joint, 27 cases of hip joint), 57 cases of aseptic loosening (16 cases of knee joint, 41 cases of hip joint), and 63 cases of normal follow-up patients after hip (35 cases) or knee (28 cases) arthroplasty.The levels of D-dimer, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were collected.The levels of D-dimer in patients with chronic PJI of hip and knee joints were compared by Mann-Whitney U test.The diagnostic efficacy of D-dimer, ESR and CRP in chronic PJI of hip and knee joints was analyzed by receiver operator curve (ROC). Results Thnt, but the value of D-dimer in the diagnosis of chronic PJI is not better than ESR and CRP.Objective To examine the clinical effects of the treatment of knee osteoarthritis patients with kinematic alignment technique of total knee replacement (KA-TKA) assisted by patient-specific instrumentation (PSI). Methods The clinical data of 14 patients with knee osteoarthritis treated with unilateral KA-TKA assisted by PSI at Department of Orthopaedic Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University from May 2018 to August 2019 were analyzed retrospectively. There were 6 males and 8 females, aged 66.6 years (range 56 to 79 years), 9 left knees and 5 right knees. The operation time, soft tissue release and extra varus or valgus osteotomy were recorded. The data of osteotomy blocks were measured and compared with the corresponding position of the prostheses. The hip knee ankle angle (HKA), the mechanical distal femoral lateral angle (mLDFA) and the proximal tibial medial angle (MPTA) were measured before and 3 months after the operation. The knee joint functional score (KS-F) , knee ve (t=-14.675, P=0.000).WOMAC Osteoarthritis Index decreased from 53.5 (25.75) (M(Q(R))) preoperative to 5.5 (5.25) postoperative (Z=-3.297, P=0.001) .No statistically significant difference was found in mLDFA and MPTA before and after surgery. No significant patellofemoral complication was recorded during follow-up time. Conclusions PSI assisted TKA resection has high accuracy. KA-TKA aims to restore the native anatomy of the knee joint, only corrects the malalignment of lower extremities caused by articular cartilage wear, with less interference to soft tissues, easy to obtain satisfactory knee joint laxity and has a promising early clinical effect.Objective To compare the short-term efficacy of unicompartmental knee arthroplasty (UKA) and total knee arthroplasty(TKA) in the treatment of medial compartmental knee osteoarthritis. Methods A retrospective analysis was performed on 197 patients with medial compartment osteoarthritis of the knee treated by the same group of doctors from January 2015 to December 2018.There were 86 males and 111 females, aged (67.7±10.5) years (range 46 to 92 years), among which 101 cases received UKA and 96 cases received TKA.The UKA and TKA patients were matched by the propensity score matching method, and a total of 41 pairs of patients were successfully matched.The difference of short-term outcomes between the two groups were compared by t test, χ(2) test or Fisher exact probability methods. Results Compared with TKA group, the postoperative reduction of hemogloblin in the UKA group was lower ((15.3±6.4) g/L vs. (20.1±7.5) g/L, t=-3.117, P less then 0.01), opioid dosage was lower ((160.5±29.3) mg vs. (186.1±46.8) mg, t=-2.