Manningcorneliussen2585

BACKGROUND Patellofemoral pain (PFP) is defined biomechanically, but is characterised by features that fit poorly within nociceptive pain. Mechanisms associated with central sensitisation may explain why, for some, symptoms appear nociplastic. This study compares psychological and somatosensory characteristics between those with persistent PFP and controls. METHODS 150 adults with PFP were compared to 61 controls. All participants completed a survey evaluating participant characteristics, PFP-related constructs and psychological factors anxiety, depression, pain catastrophizing, kinesiophobia, pain self-efficacy. Participants also attended a session of somatosensory testing, which included knee and elbow thermal and mechanical detection and pain thresholds, conditioned pain modulation (CPM), and temporal summation of pain (TSP). Differences were evaluated using analysis of covariance (sex as covariate). Multivariate backward stepwise linear regression examined how psychological and somatosensory variables relnically-induced pain is likely amplified in those with patellofemoral pain. (3) Pain-related fear is highly prevalent and helps explain patellofemoral pain-related disability. WHAT'S ALREADY KNOWN ABOUT THIS TOPIC? (1) Pressure pain threshold can be lower in individuals with patellofemoral pain. WHAT DOES THIS STUDY ADD? (1) This is the first study to explore a combined range of psychological and psychophysical tests in patellofemoral pain. (2) This study provides strong evidence of nociplastic pain in patellofemoral pain. This article is protected by copyright. All rights reserved.AIM To identify training strategies and determine how registered health and social care practitioners change their practice post Mental Capacity Act training. DESIGN Narrative literature review DATA SOURCES Seventeen databases were searched up to December 2019; CINAHL, Social Care Online, PubMed, Social Policy and Practice, Discover, Medline, Science Direct, Ovid, PsycINFO, ASSIA, Social Services Abstracts, Science Direct, Academic Search Premier, Web of Science, British Nursing Index, DH-Data, King's Fund Library Catalogue. REVIEW METHODS Empirical studies of any design investigating Mental Capacity Act training were searched and screened. Data were extracted to a bespoke spreadsheet and quality assessed. Reporting followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, (PRISMA). RESULTS Of 162 papers identified, 16 were included comprising qualitative, quantitative and mixed methods studies. Trainees valued interactive training with close alignment to practice. Training did not leadapacity to make decisions are given the best opportunity to act autonomously. This article is protected by copyright. All rights reserved.The circadian clock controls and adapts diverse physiological and behavioral processes according to Earth's 24-h cycle of environmental changes. The master pacemaker of the mammalian circadian clock resides in the hypothalamic suprachiasmatic nucleus, but almost all cells throughout the body show circadian oscillations in gene expression patterns and associated functions. Recent studies have shown that the circadian clock gradually develops during embryogenesis. Embryonic stem cells and induced pluripotent stem cells do not show circadian oscillations of gene expression, but gradually develop circadian clock oscillation during differentiation; thus, the developmental program of circadian clock emergence appears closely associated with cellular differentiation. Like embryonic stem cells, certain cancer cell types also lack the circadian clock. Given this similarity between embryonic stem cells and cancer cells, interest is growing in the contributions of circadian clock dysfunction to dedifferentiation and cancer development. In this review, we summarize recent advances in our understanding of circadian clock emergence during ontogenesis, and discuss possible associations with cellular differentiation and carcinogenesis. Considering the multiple physiological functions of circadian rhythms, circadian abnormalities might contribute to a host of diseases, including cancer. Insights on circadian function could lead to the identification of biomarkers for cancer diagnosis and prognosis, as well as novel targets for treatment. © 2020 The Japanese Urological Association.Familial hypercholesterolemia (FH) is the most common inherited form of high cholesterol that significantly increases the risk for coronary artery disease. Early detection and treatment can decrease morbidity and mortality and provide important risk information to family members. However, FH remains vastly underdiagnosed and undertreated. Cascade screening is the process of iteratively testing first-degree relatives for a genetic disease. It has been shown to effectively identify individuals with undiagnosed FH. The majority of research on methods for cascade screening has been conducted outside of the United States (U.S.). For indirect contact, index cases encourage relatives to undergo testing, and for direct contact, healthcare providers (HCP) obtain the index case's consent to contact relatives and offer information. Currently, there is not an accepted strategy for cascade screening programs in the U.S. This study investigated perspectives on direct and indirect contact for cascade screening from individuals with FH. An online survey was designed in collaboration with the Familial Hypercholesterolemia Foundation (FHF). Fifty-eight percent of U.S. index cases (11/19, 57.9%) and all international index cases (8/8, 100%) indicated willingness to provide contact information for certain at-risk relatives to a HCP for the purpose of directly informing relatives of their risk for FH in a hypothetical scenario. These findings provide an example of U.S. data and additional international data suggesting that some individuals with FH may consider direct contact a reasonable approach to improve screening uptake among family members. These initial findings need further confirmation in a larger group. © 2020 National Society of Genetic Counselors.BACKGROUND Bibliometric analysis aids to quantify the research prolificacy. The citation count acquired by a scientific article is one of the measures of its influence within a field. AIM To employ bibliometrics to offer a quantitative-qualitative analysis of publications on Early Childhood Caries (ECC) published between 1950 and 2019 DESIGN Two researchers independently read all the titles and abstracts of articles retrieved from Scopus database on October 16, 2019. The articles were categorized according to citation and study characteristics. Collaboration network among authors, countries, and keywords was generated using VOSviewer software. RESULTS Among a total of 10578 articles published on ECC, 100 most cited articles were sorted. The top-cited articles appeared in 34 journals, with Community Dentistry and Oral Epidemiology journal (n=18) contributing maximum number of articles. The papers originated from 25 countries, with the United States (n=54) accounting for largest number. Amid the papers with high levels of evidence, 11 were systematic reviews and 8 were randomized clinical trials. The topic most commonly addressed was etiology/associated factors (63%). Amongst a total of 990 keywords, "dental caries" appeared 89 times. CONCLUSION The findings of this paper will help researchers, academicians, and students for appropriate article referrals for evidence-based clinical decision making. This article is protected by copyright. All rights reserved.OBJECTIVES The aim of this population-based, retrospective study was to analyze biological and clinical features and treatment results in children diagnosed with MPAL in all Polish pediatric oncology centers between 2007 and 2018. METHODS Among 2,893 children and adolescents diagnosed and treated for acute leukemia, 39 (1.35%) patients fulfilled the WHO criteria of MPAL. The T/myeloid phenotype was most prevalent. RESULTS Cytogenetics findings were seen in 2 (5.1%), while chromosomal abnormalities were found in 14 (35.9%) patients. Thirty-two patients achieved CR-1, including 23 (92.0%) treated with ALL-directed chemotherapy and 9 (64.3%) treated with AML-type induction regimens. Within these patients, 4 (12.5%) died due to treatment-related complications and 11 (34.4%) relapsed. Nineteen (63.3%) patients underwent allo-HSCT in CR-1 and 14 (73.7%) of them have been in CR-1. In total, 17 (43.6%) patients remain in CR-1 for 1 - 12 years, including 14 (58.3%) with T/myeloid MPAL. The 5-year pOS and pEFS were 51.8% and 44.2%, respectively. The overall survival for ALL-directed therapy was significantly better than the one for AML-type chemotherapy (p=0.001). It was also better for patients who underwent HSCT in CR-1 (p=0.001). https://www.selleckchem.com/products/nlg919.html CONCLUSIONS The prognosis of MPAL is unsatisfactory, but initial treatment with ALL-directed chemotherapy consolidated with allo-HSCT improves the outcomes in MPAL. This article is protected by copyright. All rights reserved.If you're like me, in recent days you've experienced moments of fear. Feelings like when you woke up in bed at night as a kid, and saw a dark shadow in the corner, and wondered if it was going to get you. If you're like me, in recent days you've also experienced awe at so many triumphs over such fear, individual and collective - our 65 year old ED clerk showing up to their shift, through great anxiety, or healthcare providers boarding buses heading into the teeth of the Wuhan epidemic. The pages of AEM this month provide further examples of such triumphs, of individuals in a time and place of great stress overcoming the impulse to curl up and focus on themselves, and instead expanding beyond themselves to help others. This is the finest tradition of humanity and medicine, and all of these efforts at service through science inspire and give heart. This article is protected by copyright. All rights reserved.AIM To describe mother's experiences of feeding their extremely preterm infant. BACKGROUND When an infant is born extremely preterm, there is a long rocky road for the mother if she wants to breastfeed. Some manage to reach their goals, others do not. Studies of feeding extremely preterm infants in the neonatal intensive care unit (NICU) are scarce. DESIGN A qualitative method with an inductive approach. METHODS Nine mothers giving birth to extremely preterm infants were interviewed by telephone after discharge from the NICU. The interviews were transcribed verbatim and analysed with qualitative content analysis. The COREQ checklist was followed. Findings The overall theme was "you can't flight, you need to fight". The theme reflects the mothers will to do the best for their infants even if the struggle with milk expression and breastfeeding practice evoked feelings of helplessness, exposure, worry, and disappointment. The categories forming the theme were The wish to provide own breastmilk; For the infant's best; Loss of control; Help to reach the goals. CONCLUSION The mothers had a strong will to provide breastmilk to their infants but requested more support in order to be successful. RELEVANCE TO CLINICAL PRACTICE There is a need for evidence based support programs for mothers of extremely preterm infants to encourage them to persevere with milk expression and breastfeeding over time. This article is protected by copyright. All rights reserved.