Lundehoffmann9348

Disease models of vascular dementia or stroke, depression or anxiety, schizophrenia, epilepsy or seizure, diabetes and traumatic brain injury, among others, have also been used. For assessing cognition, there also exists a vast variety of behavioral tests to choose from.

Since a variety of etiologies can affect the cognitive processes, hence a nootropic agent may be screened in a variety of disease models. The most widely used and appropriate method to assess cognition would be by combining the behavioral and biochemical assays so that a more comprehensive profile about the nootropic effects of a drug can be elicited.

Since a variety of etiologies can affect the cognitive processes, hence a nootropic agent may be screened in a variety of disease models. The most widely used and appropriate method to assess cognition would be by combining the behavioral and biochemical assays so that a more comprehensive profile about the nootropic effects of a drug can be elicited.

Radiopharmaceuticals are used for diagnosis, treatment, staging and follow up of various diseases. However, there is concern that the ionizing radiation (gamma rays, α and ß particles) may result in the exposure of radiographers with limited knowledge of the principles of radiation protection and safety, raising the risk of cancer induction.

To investigate the knowledge and level of radiation safety awareness among radiographers at a tertiary hospital.

It is an analytical cross-sectional study. A validated two-part questionnaire was implemented to consenting radiographers in a Nuclear Medicine Department. Part 1 gathered demographic information (age, gender, work experience, attendance to/or passing ionizing radiation protection courses). Part 2 covered questions related to knowledge and level of awareness of radiation protection principles.

Five radiographers voluntary participated (2/5 were males while 3/5 were females). Three age groups were distinguishable, 21-30, 41-50 and 51-60 years. In the age group of 21-30 years, there was one male with just over 4 years of experience while in the age group 41-50, there were three females with less than three years of experience and in the age group 51-60, there was one male radiographer with over 20 years of experience. All the radiographers showed a high level of awareness and knowledge of radiation safety principles.

Education coupled with training in radiation protection is an essential tool for instilling radiation awareness among radiographers. However, education alone is not enough, further skills in preparation and administration of radiopharmaceuticals will reduce exposures.

Education coupled with training in radiation protection is an essential tool for instilling radiation awareness among radiographers. However, education alone is not enough, further skills in preparation and administration of radiopharmaceuticals will reduce exposures.To date, no accepted therapy exists for treating the emerging infectious disease nCOVID-19 in a safe and effective way. Although various types of treatment options are under the developing phase around the world, among those, several studies concerning convalescent plasma (CP) from recovered patients reported promising effects against nCOVID-19 infected critically ill patients nowadays. The therapy showed very few adverse effects, and it helps to diminish the viral load when administered at an early stage of infection. TEN-010 Convalescent plasma appears to be safe for critically ill nCOVID-19 patients by decreasing serum viral loads, and most cases are virus negative after CP transfusion. The convalescent plasma can be good as it has already been utilized to treat previous pandemics like Ebola, influenza, and SARS-CoV infection. In this review article, we pointed out the background, rationality, mechanisms, and safety outcomes of CP to treat nCOVID-19 infected patients.

The study aimed to investigate the antidiabetic activity of Artemisia arborescens.

Artemisia arborescens is an aromatic, medicinal, and endemic plant in Mediterranean region. This plant is widely used in alternative medicine.

The study was designed to examine the antihyperglycemic and antihyperlipidemic activities of Artemisia arborescens aqueous extract (AEAA) in normal and streptozotocin(STZ)- induced diabetic rats.

The effect of AEAA (40 mg/kg and 80 mg/kg) on plasma glucose levels and plasma lipid profile was investigated in normal and STZ-induced diabetic rats. The plasma glucose levels were determined after a single (6 hours) and subchronic oral administration (7 days) and plasma lipid profiles have been evaluated after both acute and subchronic oral administration. Additionally, the glycogen content in the liver, extensor digitorum longus (EDL), and soleus muscles was measured using a standard method. Moreover, the aqueous extract was tested for its 1.1-diphenyl-2-picrylhydrazyl (DPPH) radical-ion exhibited a significant antihyperglycemic effect in diabetic rats and revealed a significant amelioration in lipid profile and glycogen content.

In summary, the study demonstrates that Artemisia arborescens oral administration exhibited a significant antihyperglycemic effect in diabetic rats and revealed a significant amelioration in lipid profile and glycogen content.

There are several controversies about the association between serum magnesium depletion and microalbuminuria in type 2 diabetic patients.

Therefore, this study was aimed to assess the serum magnesium concentrations in Type 2 diabetic patients with microalbuminuria and normoalbuminuria in Birjand, Iran, in 2019.

In this cross-sectional study, 25 type 2 diabetes patients with microalbuminuria were enrolled as the case group and 25 type 2 diabetes patients with normoalbuminuria as the control group. Both groups were matched for age, sex, hypertension, and dyslipidemia. Blood samples were obtained for serum magnesium measurement.

Our findings showed that there was no significant difference between serum magnesium concentration in the case and control groups (Mean serum magnesium concentration for case group 2.34 ± 0.35 mg/dl and control group 2.27 ± 0.33 mg/dl). Pearson correlation coefficient analysis did not show the correlation between serum magnesium levels and urine albumin levels in patients with microalbuminuria versus patients with normoalbuminuria (r = 0.06, p = 0.67).

This study did not indicate the correlation between serum magnesium concentrations and microalbuminuria in Type 2 diabetic patients.

This study did not indicate the correlation between serum magnesium concentrations and microalbuminuria in Type 2 diabetic patients.Cancer has a significant social consequence all around the globe. In 2020, approximately 193 lakh new cases of cancer were diagnosed worldwide, with about 100 lakhs cancer deaths. In the next two decades, suspected cases are anticipated to increase by roughly 47%. The rising number of cancer patients, as well as the inadequacy of traditional chemotherapeutic agents, radiation, and invasive surgical procedures, all rely on massive cell death with hardly any selectivity, causing severe toxicities. In comparison to synthetic medications, there has subsequently been a surge in international importance in non-synthetic and alternative remedies, owing to improved adaptability and reduced side effects of drug responses. Several people with cancer prefer alternative and complementary therapy treatments, and natural remedies play a crucial role in cancer chemoprevention as they are thought to be harmless, offer fewer negative effects, and become less sufficient to evoke addiction by the wider population. Chemopreventive, anti-metastatic, cytotoxic, and anti-angiogenic actions are among the promising clinical advantages, which have been established in vitro research and certain clinical trials; nevertheless, additional clinical trials are needed. This review examines several phytochemicals that may have anti-cancer and chemopreventive properties.Background This study is part of a larger research effort to explore the molecular mechanism of hepatocellular carcinoma, reduce drug resistance and seek new targets. Objective To investigate the effect and mechanism of fibroblast growth factor receptor inhibitor AZD4547 on Sorafenib-resistant hepatoma cells. Methods First we constructed a Sorafenib-resistant hepatoma cell line Huh7R. Different groups of Huh7R cells were treated with Sorafenib, AZD4547, Sorafenib combined with AZD4547, and normal saline. The cell viability was detected by Cell Counting Kit-8. Then Fibroblast growth factor receptor and Toll-like receptor 4 were detected by Western blot, as well as the LC3 II/I, Beclin1, and P62. In addition, we used the autophagy inhibitor 3-methyladenine to identify the mechanism of AZD4547 combined with Sorafenib for inducing Sorafenib-resistant hepatoma cell death. Results We find that AZD4547 combined with Sorafenib significantly inhibited the viability of Sorafenib-resistant hepatoma cell Huh7R. As for its mechanism, AZD4547 was able to inhibit fibroblast growth factor receptor activity, promote autophagy and regulate immunity. AZD4547 increased LC3 II/I, Beclin1, and Toll-like receptor 4 proteins, and decreased P62 protein level in Huh7R cells significantly when given in combination with sorafenib. Furthermore, 3-methyladenine inhibited autophagy and reversed the killing effect of the combination of AZD4547 and Sorafenib on Huh7R cells. Conclusion The inhibition of fibroblast growth factor receptor activity by AZD4547 can significantly enhance autophagy and immune response, as well as promote the death of Sorafenib-resistant hepatoma cells.

Camptothecin is a naturally occurring alkaloid obtained from the stem wood of the Chinese tree, Camptotheca acuminata. Its pharmacological effect is because it has ability to selectively inhibit the type-I topoisomerase DNA nuclear enzyme. Several semisynthetic analogs of camptothecin have been synthesized till date possessing antitumor activity.

Camptothecin (CPT) is one of the most promising anticancer drugs but it produces various side effects because of its non-selectivity towards cancer cells. To overcome these adverse effects, we have synthesized biotin conjugate of camptothecin which was linked via a self immolative disulfide linker (CPT-SS-Biotin).

Biotin conjugated camptothecin linked through a disulfide bond was synthesized following schemes mentioned in paper and the structural characterization was carried out. The stability and drug release studies were performed in the presence of glutathione (GSH) while in vitro studies were performed on 4T1 tumor cell lines. In vivo pharmacological investon of camptothecin via disulfide linker can be developed as safe and efficacious cancer therapeutics.

In-vivo tumor suppression studies and in vitro cell line studies along with serological parameters and histopathological studies showed that conjugate produced high therapeutic effect and remarkably reduced toxic effects in comparison to free CPT. The results suggested that biotinylation of camptothecin via disulfide linker can be developed as safe and efficacious cancer therapeutics.

Photodynamic therapy (PDT) is a therapeutic intervention that can be applied to cancer treatment. The interaction between a photosensitizer (PS), ideal wavelength radiation, and tissue molecular oxygen triggers a series of photochemical reactions responsible for producing reactive oxygen species. These highly reactive species can decrease proliferation and induce tumor cell death. The search for PS of natural origin extracted from plants becomes relevant, as they have photoactivation capacity, preferentially targeting tumor cells and because they do not present any or little toxicity to healthy cells.

Our work aimed to carry out a qualitative systematic review to investigate the effects of curcumin (CUR), a molecule considered as PS of natural origin, on PDT, using red light or near-infrared radiation in tumor models.

A systematic search was performed in three databases (PubMed, Scopus, and Web of Science) using the PICOT method, retrieving a total of 1,373 occurrences. At the end of the peer screening, 25 eligible articles were included in this systematic review using inclusion, exclusion, and eligibility criteria.