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nt under strong control examination and detection was increased for 10,7 and 24,7% compared with 2016 year and got 93,8% and 93,7% in 2019 year.Aim - to investigate the relationship between immunological parameters, level of viral load and severity of morphological changes in the liver according to non-invasive tests in HBeAg-negative patients with chronic hepatitis B. The study included 55 HBeAg-negative patients with chronic hepatitis B. Age of patients was from 20 to 78 years. There were 20 women and 35 men. Quantitative content of HBV-DNA, HBeAg and anti-HBe, TNF-α and IFN-γ was determined in all patients› blood. Statistical processing was performed in Statistica 13 for Windows (StatSoft Inc., No. JPZ804I382130ARCN10-J). The study found an association between HBeAg/anti-HBe seroconversion and severity of liver fibrosis. It is shown that in the presence of liver fibrosis F 2-4 degree the frequency of seroconversion is lower compared with HBeAg-negative patients with F 0-1 (85,7 % vs. 100 %, p 20,000 IU / ml has a relationship with necroinflammatory activity, significantly higher with A 2-3. The TNF-α content is higher than in healthy people (p less then 0.05), and has no significant relationship with the severity of morphological changes in the liver according to non-invasive tests. The content of IFN-γ in the blood serum of HBeAg-negative patients with CHB does not statistically differ from those of healthy people.Amyotrophic Lateral sclerosis (ALS ) is a fatal progressive neurodegenerative disease that affects the upper and lower motoneurons. .The disease is characterized by a plethora of neurological symptoms. There is a lot of information in the medical literature about ALS phenotypes, but the clinical diversity of ALS has not been studied in the Caucasus region and a unified clinical picture has not been conclusively established. In this regard, it is very important to study the symptoms among patients with ALS in Georgia. From 2018 to 2021, we examined 47 patients with ALS living in Georgia from different parts of the country, 23 - female, 24 - male, diagnosed based on clinical picture, electromyographic studies (AWAJI) and who met the EL ESCORIAL -Revised criteria. Also clinical symptom studies were conducted using the Mayo Clinic Laboratory Neurological Questionnaire. Cognitive changes were assessed using Addenbrooke's Cognitive Examination scale (ACE III) and the Frontal Behavioral Questionnaire, the patient's quality of life was assessed by ALSFRS-R. Patients were 26 to 84 years old, the age of onset of the disease was 58-60 years in men, 55-57 years in women. The bulbar type was observed in 21.3%, the upper limb type in 38.3% and the lower limb type in 40.4%. Frontotemporal dementia (FTD), diagnosed in 6 patients (12.7%). No reliable correlation was found between the forms of ALS and FTD. The results of the study showed that ALS is a multisystem disease and is not limited to damage to motoneurons. It is safe to say that ALS has characteristics of polysystemic degeneration, with the predominance of motorneuron damage. Therefore, we consider it advisable to screen all patients with ALS for additional symptoms with a focus on the examination of cognitive function, which ensures the proper management of the disease in the future.The aim of the work was to find out whether markers of bone formation can be early predictors of osteoporosis in patients with COPD. The study involved 66 patients with COPD with disease duration from 10 to 30 years, age 53.59±12.83 years. 37 (66.06%) patients smoked, the pack / year index was (29.08±16.62). According to the results of CAT testing, all patients were divided into 4 clinical groups GOLD I-IV. The content of serum markers of bone formation was determined N-terminal procollagen type I propeptide (PINP), osteocalcin and vitamin D depending on the age and severity of COPD. A decrease in all markers of bone formation was found with the age of patients and the severity of COPD. Thus, in patients under 45 years, the P1NP level was 48.75% higher than in patients aged 75 and older (p less then 0.001). A significant relationship was established between the age of patients and the P1NP level (r= -0.46; p= less then 0.05). With GOLD I, a decrease in the P1NP content was observed in 40.0% of patients, with markers of bone tissue formation is inhibited. These processes occur against the background of vitamin D deficiency. As a result of this imbalance, favorable conditions are created for the development of osteoporosis. Considering that the first signs of these disorders, in particular a decrease in the levels of vitamin D and osteocalcin, are diagnosed already with GOLD I, it can be argued that COPD is the leading factor.Recent studies have revealed a strong association between Coronary Artery Disease (CAD) severity and arterial stiffness parameters, such as Pulse Wave Velocity (PWV). The majority of studies mainly using carotid-femoral PWV (cfPWV) or brachial-ankle PWV (baPWV). selleck kinase inhibitor The emerging data have indicated that oscillometrically PWVao proved to be an independent marker of atherosclerotic cardiovascular disease (ASCVD), as well. The main goal of the present study has been to compare the oscillometrically measured parameters of aortic stiffness between patients with Acute Coronary Syndrome (ACS) and patients with stable ischemic heart disease (SIHD). In 100 patients with Acute Coronary Syndrome (Group 1) and 91 patients with Chronic Coronary Syndrome (Group 2) arterial stiffness was assessed by oscillometrically measured complex arterial function. The highest strength of the association revealed between Aortic Pulse Wave Velocity, PWVao (m/s), and incidence of Acute Coronary Syndrome (ACS) with Odds Ratio (OR) of 9.41; 95% CI (4.86, 18.2). Next was Augmentation Index, AIx (%) with OR=5.11; 95% CI (2.65, 9.86), and last Central Systolic Blood Pressure SBPao (mmHg) with OR=3.15; 95% CI (1.63, 6.1). An oscillometrically measured parameters of arterial stiffness, such as Aortic Pulse Wave Velocity (PWVao), Augmentation Index (AIx), and Central Systolic Blood Pressure (SBPao) may be useful in terms of early risk stratification and prevention of Acute Coronary Syndrome (ACS).The ecological condition of different cities and regions in Georgia is variable. The level of anthropogenic contamination with xenobiotics in most of them significantly exceed the normal level. In almost 25% of children residing in Tbilisi, Batumi and Kutaisi the level of xenobiotics varies 5.0-10.0 mkg/dL, 16% of children have higher than 10.0 mkg/dL. We have studied the profile of mental and speech development in children living in abovementioned cities according to the level of Pb in blood. On the basis of representative selection we have studied the level of Pb in the range of 5.0 mkg/dL and 10.0 mkg/dL for two groups of children with normal development 65.5 months- (I study group) and 89.5 months (II-study group). Control group has no Pb in blood. link2 The situation in family was also considered. Intellectual development was assessed by Wexler verbal and nonverbal subtests, neuropsychological methods by Luria-Kristensen and visual-motor and visual-spatial evidence by WBAVMA. According to results of children from group I living in ecologically unfavourable regions average evidence for mental and speech verbal awareness were within normal range and similar to controls. As for group II the difference from normal age range was not found. The development of awareness of false belief of second order for group-I was significantly delayed which could occur due to pitfalls in cognitive field. The redevelopment of structure of motivated behaviour in children from group-I was significantly restricted compared with group-II and controls.Purpose - study of the physical development of preschool children, taking into account gender characteristics and comparison with identical data from the study of 1968, 1972, 1986, 2000s. Object of the research 968 children aged 3-6 years, living in the central, southern and northern regions of the country, who underwent an anthropometric study using standard instruments. Also, the results were compared with the research data from 1968, 1972, 1986, 2000s. The body weight of boys 3-5 years old significantly exceeded that of girls (р0,05). When conducting a comparative analysis of the body length and body weight of children in Kazakhstan with the WHO standards, there were no significant differences. At the same time, the head circumference of 3-year-old boys and 3-4-year-old girls exceeds the identical indicators according to WHO (р less then 0.05). This fact is possibly related to the climatic, ethnic and social-everyday characteristics of the children. The latter, once again indicates the need to develop regional standards, since WHO standards are likely to be a guideline. A comparative analysis of the basic indicators of the physical development of children over the period from 1968 to 2019 demonstrates a gradual increase in somatometric indicators in most age groups. The physical development of preschool children in the Republic of Kazakhstan at the present stage is quite harmonious. A retrospective analysis of the physical development of children aged 3-6 years over the past 50 years has shown a significant increase in body length, without a significant increase in body weight in modern children, which indicates the ongoing process of acceleration with a tendency to asthenization.Aim - improvement of efficiency assessment methods of therapy of mycoplasma infection in children with bronchial asthma. The effectiveness of treatment of mycoplasma infection in the period of exacerbation of bronchial asthma in 250 children, aged 1 to 7 years, was evaluated. The children were on basic therapy and received treatment with azithromycin three courses at a dose of 10 mg/kg of weight for 3 days with an interval of 4 days 5-7 days. link3 Microbiological (culturing), immunological (DIF, AHAA), and genetic (PCR) methods were used to identify mycoplasma markers. The main focus was on identifying two species - M. pneumoniae and M. hominis, most commonly found in mycoplasma respiratory infections, including bronchial asthma. In 250 children with bronchial asthma, antigens of Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Mycoplasma arthritidis and Mycoplasma fermentrans were detected in 62,8%, 42,8%, 46,8 %, 31,6%, 45,6% of cases, respectively. A detailed study of the presence of M. pneumoognosis of bronchial asthma in patients.The objective of this work was to identify prognostic factors of the environment and heredity in the families of girls with abnormal uterine bleeding during puberty. Clinical and genealogical analysis has been carried out according to P. Harper in the families of 70 girls with abnormal uterine bleeding (AUB) during puberty. The control group consisted of families of 30 healthy girls 12-18 years old with a regular menstrual cycle without severe somatic pathology, which have been selected during preventive examinations in educational institutions by specialists of the institute. Statistical analysis of the data has been carried out with the Student's t-test and χ2 for unequal samples using Excel and SPSS Statіstіcs 17.0. Prognostic signs have been selected using Valda's criterion. On the basis of the analysis, the family accumulation of multifactorial pathology has been revealed. The risk factors of AUB have been identified hereditary burden for reproductive disorders, harmful working conditions and bad habits of parents before conceiving a child, maternal stress before pregnancy, early maternal age during pregnancy (up to 20 years), unfavorable course of pregnancy and childbirth, mixed feeding of infants, stress of girls at home and in an educational institution.